Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors

2014 ◽  
Vol 193 ◽  
pp. 2-8 ◽  
Author(s):  
Jun Akimoto ◽  
Masamichi Nakayama ◽  
Teruo Okano
Keyword(s):  
Solid Tumors ◽  
Drug Targeting ◽  
Polymeric Micelles ◽  
Temperature Responsive

Polymeric micelles using cholinium-based ionic liquids for the encapsulation and drug release of hydrophobic molecules

2021 ◽  
Author(s):  
Isabelle Kurnik ◽  
Natália D’Angelo ◽  
Priscila Gava Mazzola ◽  
Marlus Chorilli ◽  
Daniel Kamei ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Drug Release ◽  
Polymeric Micelles ◽  
Amphiphilic Copolymer ◽  
Two Phase ◽  
Temperature Responsive ◽  
Micellar Systems

We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The...

scholarly journals Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 347
Author(s):  
Lavinia Salama ◽  
Elizabeth R. Pastor ◽  
Tyler Stone ◽  
Shaker A. Mousa
Keyword(s):  
Cancer Cells ◽  
Drug Targeting ◽  
Polymeric Micelles ◽  
Chemotherapeutic Agents ◽  
Diagnosis And Treatment ◽  
Medicinal Products ◽  
Cancer Management ◽  
High Doses ◽  
Risk Of Cancer ◽  
Nutraceutical Products

Nanotechnology is the science of nanoscale, which is the scale of nanometers or one billionth of a meter. Nanotechnology encompasses a broad range of technologies, materials, and manufacturing processes that are used to design and/or enhance many products, including medicinal products. This technology has achieved considerable progress in the oncology field in recent years. Most chemotherapeutic agents are not specific to the cancer cells they are intended to treat, and they can harm healthy cells, leading to numerous adverse effects. Due to this non-specific targeting, it is not feasible to administer high doses that may harm healthy cells. Moreover, low doses can cause cancer cells to acquire resistance, thus making them hard to kill. A solution that could potentially enhance drug targeting and delivery lies in understanding the complexity of nanotechnology. Engineering pharmaceutical and natural products into nano-products can enhance the diagnosis and treatment of cancer. Novel nano-formulations such as liposomes, polymeric micelles, dendrimers, quantum dots, nano-suspensions, and gold nanoparticles have been shown to enhance the delivery of drugs. Improved delivery of chemotherapeutic agents targets cancer cells rather than healthy cells, thereby preventing undesirable side effects and decreasing chemotherapeutic drug resistance. Nanotechnology has also revolutionized cancer diagnosis by using nanotechnology-based imaging contrast agents that can specifically target and therefore enhance tumor detection. In addition to the delivery of drugs, nanotechnology can be used to deliver nutraceuticals like phytochemicals that have multiple properties, such as antioxidant activity, that protect cells from oxidative damage and reduce the risk of cancer. There have been multiple advancements and implications for the use of nanotechnology to enhance the delivery of both pharmaceutical and nutraceutical products in cancer prevention, diagnosis, and treatment.

Temperature-Responsive Mixed-Shell Polymeric Micelles for the Refolding of Thermally Denatured Proteins

2013 ◽  
Vol 19 (23) ◽  
pp. 7437-7442 ◽  
Author(s):  
Xue Liu ◽  
Yang Liu ◽  
Zhenkun Zhang ◽  
Fan Huang ◽  
Qian Tao ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Temperature Responsive ◽  
Denatured Proteins

Evaluation of Anti-Tumor Efficacy of Vorinostat Encapsulated Self-Assembled Polymeric Micelles in Solid Tumors

2018 ◽  
Vol 19 (7) ◽  
pp. 3141-3151 ◽  
Author(s):  
Sri Vishnu Kiran Rompicharla ◽  
Prakruti Trivedi ◽  
Preeti Kumari ◽  
Omkara Swami Muddineti ◽  
Sowmya Theegalapalli ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Polymeric Micelles ◽  
Self Assembled
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