Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal ® FS system, and polyglycolic acid sheets as wound coverings after oral surgery

2017 ◽  
Vol 45 (9) ◽  
pp. 1458-1463 ◽  
Author(s):  
Atsumu Kouketsu ◽  
Shinnosuke Nogami ◽  
Minami Yamada-Fujiwara ◽  
Hirokazu Nagai ◽  
Kensuke Yamauchi ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Oral Surgery ◽  
Polyglycolic Acid ◽  
Clinical Evaluations ◽  
Autologous Fibrin Glue

Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as oral surgical wound coverings after partial glossectomy

2016 ◽  
Vol 44 (8) ◽  
pp. 964-968 ◽  
Author(s):  
Atsumu Kouketsu ◽  
Shinnosuke Nogami ◽  
Minami Fujiwara ◽  
Shiro Mori ◽  
Kensuke Yamauchi ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Surgical Wound ◽  
Clinical Evaluations ◽  
Autologous Fibrin Glue ◽  
Partial Glossectomy

Application of Polyglycolic Acid Sheets and Fibrin Glue Spray to Bone Surfaces During Oral Surgery: A Case Series

2015 ◽  
Vol 73 (5) ◽  
pp. 1017.e1-1017.e6 ◽  
Author(s):  
Satoshi Rokutanda ◽  
Souichi Yanamoto ◽  
Shin-ichi Yamada ◽  
Tomofumi Naruse ◽  
Satoshi Inokuchi ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Oral Surgery ◽  
Case Series ◽  
Polyglycolic Acid

scholarly journals Utility of autologous fibrin glue and polyglycolic acid sheet for preventing delayed bleeding associated with antithrombotic therapy after gastric ESD

2019 ◽  
Vol 07 (11) ◽  
pp. E1542-E1548
Author(s):  
Daisuke Kikuchi ◽  
Toshiro Iizuka ◽  
Shigeyoshi Makino ◽  
Junnosuke Hayasaka ◽  
Hiroyuki Odagiri ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Antithrombotic Therapy ◽  
Polyglycolic Acid ◽  
Conventional Group ◽  
Serious Adverse Events ◽  
Bleeding Rate ◽  
Allogeneic Transfusion ◽  
Delayed Bleeding ◽  
Autologous Fibrin Glue ◽  
Adjusted Logistic Regression

Abstract Background and study aims Delayed bleeding is one of the most serious adverse events of gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic therapy. This study aimed to evaluate the utility and safety of a shielding method with autologous fibrin glue and polyglycolic acid (PGA) sheets for patients undergoing gastric ESD who are receiving antithrombotic therapy. Patients and methods One hundred twenty-three patients who were treated with gastric ESD while receiving antithrombotic therapy between December 2014 and September 2017 were enrolled in this study. Patients who received the shielding method were classified into the shielding group. Others were classified into the conventional group. Various clinico-pathological factors were retrospectively compared between the two groups. Results The shielding group consisted of 38 patients, and the conventional group consisted of the remaining 85 patients. In the shielding group, the rate of continuation of antithrombotic therapy was significantly higher (68.4 % vs 41.2 %). Incidence of delayed bleeding was lower in the shielding group (2.6 %, 1/38) than in the conventional group (14.1 %, 12/85). In the propensity score-adjusted logistic regression analysis, the delayed bleeding rate in the shielding group tended to be lower than in the conventional group (P = 0.070). Allogeneic transfusion was performed in eight patients (8/85, 9.4 %) in the conventional group and none in the shielding group (P = 0.047). No adverse event associated with endoscopic shielding were observed in the shielding group. Conclusions This study suggests that a shielding method with autologous fibrin glue and PGA sheet effectively prevents delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.

scholarly journals Feasibility of Autologous Fibrin Glue and Polyglycolic Acid Sheets to Prevent Delayed Bleeding after Endoscopic Submucosal Dissection of Gastric Neoplasms in Patients Receiving Antithrombotic Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Daisuke Kikuchi ◽  
Toshiro Iizuka ◽  
Kosuke Nomura ◽  
Yasutaka Kuribayashi ◽  
Masami Tanaka ◽  
...  
Keyword(s):  
Adverse Events ◽  
Endoscopic Submucosal Dissection ◽  
Fibrin Glue ◽  
Antithrombotic Therapy ◽  
Polyglycolic Acid ◽  
Safety Measure ◽  
Gastric Neoplasms ◽  
Delayed Bleeding ◽  
Submucosal Dissection ◽  
Autologous Fibrin Glue

Background/Aims. Delayed bleeding is one of the most serious complications following gastric endoscopic submucosal dissection (ESD) under antithrombotic therapy. As a safety measure, for patients receiving antithrombotic therapy, we covered the ESD ulcer with autologous fibrin glue (prepared using autologous blood) alone or with polyglycolic acid (PGA) sheets. Methods. From July 2014 to November 2015, 20 patients with gastric neoplasms who were receiving antithrombotic therapy were enrolled in this study. After ESD, the ESD ulcers were covered with autologous fibrin glue alone or with PGA sheets. We prospectively evaluated the feasibility of this safety measure. Results. In total, 22 lesions in 20 patients were resected en bloc by ESD. The mean specimen size and tumor size were 31.5 ± 9.5 mm and 14.0 ± 8.8 mm, respectively. There were no cases of delayed bleeding or adverse events in this study. Attachment of autologous fibrin glue was observed in 81.8% (18/22) and 68.2% (15/22) of lesions at endoscopy performed 1 day and 7 days after ESD, respectively. Conclusion. No patient in this study had delayed bleeding or adverse events. This suggests that this measure may facilitate the safety of gastric ESD in patients receiving antithrombotic therapy. This trial is registered with UMIN000019386.

Wound healing effect of autologous fibrin glue and polyglycolic acid sheets in a rat back skin defect model

2021 ◽  
pp. 103144
Author(s):  
Atsumu Kouketsu ◽  
Yoshinaka Shimizu ◽  
Shinnosuke Nogami ◽  
Minami Yamada-Fujiwara ◽  
Hirokazu Nagai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Skin Defect ◽  
Defect Model ◽  
Healing Effect ◽  
Autologous Fibrin Glue ◽  
Wound Healing Effect

Osteoplasty in Disseminated Calvarial Defects Treated with Autologous Adipose-Derived Stem Cells and Autologous Fibrin Glue: Case Report

Skull Base ◽  
2005 ◽  
Vol 15 (S 2) ◽  
Author(s):  
Stefan Lendeckel ◽  
A. Jödicke ◽  
P. Christophis ◽  
K. Heidinger ◽  
H.-P. Howaldt
Keyword(s):  
Stem Cells ◽  
Case Report ◽  
Fibrin Glue ◽  
Adipose Derived Stem Cells ◽  
Autologous Fibrin Glue ◽  
Calvarial Defects

scholarly journals Feasibility of a modified search, coagulation, and clipping method with and without the use of polyglycolic acid sheets and fibrin glue for preventing delayed bleeding after gastric endoscopic submucosal dissection

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Satoshi Abiko ◽  
Soichiro Oda ◽  
Akimitsu Meno ◽  
Akane Shido ◽  
Sonoe Yoshida ◽  
...  
Keyword(s):  
High Risk ◽  
Endoscopic Submucosal Dissection ◽  
Median Time ◽  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Low Risk ◽  
R0 Resection ◽  
Antithrombotic Agents ◽  
Delayed Bleeding ◽  
Submucosal Dissection

Abstract Background Methods have been developed for preventing delayed bleeding (DB) after gastric endoscopic submucosal dissection (GESD). However, none of the methods can completely prevent DB. We hypothesized that DB could be prevented by a modified search, coagulation, and clipping (MSCC) method for patients at low risk for DB and by combining the use of polyglycolic acid sheets and fibrin glue with the MSCC method (PMSCC method) for patients at high risk for DB (antibleeding [ABI] strategy). This study assessed the technical feasibility of this novel strategy. Method We investigated 123 lesions in 121 consecutive patients who underwent GESD in Kushiro Rosai Hospital between April 2018 and January 2020. The decision for continuation or cessation of antithrombotic agents was based on the Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment. Results Oral antithrombotic agents were administered to 28 patients (22.8%). The en bloc R0 resection rate was 98.4%. The MSCC method and the PMSCC method for preventing DB were performed in 114 and 9 lesions, respectively. The median time of the MSCC method was 16 min, and the median speed (the resection area divided by the time of method used) was 3.6 cm2/10 min. The median time of the PMSCC method was 59 min, and the median speed was 1.3 cm2/10 min. The only delayed procedural adverse event was DB in 1 (0.8%) of the 123 lesions. Conclusions The ABI strategy is feasible for preventing DB both in patients at low risk and in those at high risk for DB after GESD, whereas the PMSCC method may be necessary for reduction of time.

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