Platelet rich plasma enhances osteoconductive properties of a hydroxyapatite-β-tricalcium phosphate scaffold (Skelite™) for late healing of critical size rabbit calvarial defects

2014 ◽  
Vol 42 (5) ◽  
pp. e70-e79 ◽  
Author(s):  
Rania M. El Backly ◽  
Samer H. Zaky ◽  
Barbara Canciani ◽  
Manal M. Saad ◽  
Ahmed M. Eweida ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Calvarial Defects

scholarly journals Additive Manufacturing of β-Tricalcium Phosphate Components via Fused Deposition of Ceramics (FDC)

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 156
Author(s):  
Steffen Esslinger ◽  
Axel Grebhardt ◽  
Jonas Jaeger ◽  
Frank Kern ◽  
Andreas Killinger ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Critical Size ◽  
Bone Defects ◽  
Healthcare Systems ◽  
The Body ◽  
Patient Specific ◽  
Poly Lactic Acid ◽  
Fused Deposition ◽  
Poly Ethylene ◽  
Fused Deposition Of Ceramics

Bone defects introduced by accidents or diseases are very painful for the patient and their treatment leads to high expenses for the healthcare systems. When a bone defect reaches a critical size, the body is not able to restore this defect by itself. In this case a bone graft is required, either an autologous one taken from the patient or an artificial one made of a bioceramic material such as calcium phosphate. In this study β-tricalcium phosphate (β-TCP) was dispersed in a polymer matrix containing poly(lactic acid) (PLA) and poly(ethylene glycole) (PEG). These compounds were extruded to filaments, which were used for 3D printing of cylindrical scaffolds via Fused Deposition of Ceramics (FDC) technique. After shaping, the printed parts were debindered and sintered. The components combined macro- and micropores with a pore size of 1 mm and 0.01 mm, respectively, which are considered beneficial for bone healing. The compressive strength of sintered cylindrical scaffolds exceeded 72 MPa at an open porosity of 35%. The FDC approach seems promising for manufacturing patient specific bioceramic bone grafts.

Influence of the proportion of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects

Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Maria Nagata ◽  
Michel Messora ◽  
Roberta Okamoto ◽  
Natália Campos ◽  
Natália Pola ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Critical Size Defects

Histologic Evaluation of Osseous Regeneration Following Combination Therapy With Platelet-Rich Plasma and Bio-Oss in a Rat Calvarial Critical-Size Defect Model

2015 ◽  
Vol 41 (5) ◽  
pp. 543-549 ◽  
Author(s):  
Philip J. DeNicolo ◽  
M. Kelly Guyton ◽  
Michael F. Cuenin ◽  
Steven D. Hokett ◽  
Mohamed Sharawy ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Growth ◽  
Critical Size ◽  
Close Contact ◽  
Platelet Rich Plasma ◽  
Critical Size Defect ◽  
Histologic Evaluation ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Stain ◽  
Osseous Regeneration

Platelet-rich plasma (PRP) is an autogenous source of growth factors shown to facilitate human bone growth. Bio-Oss, an osteoconductive xenograft, is used clinically to regenerate periodontal defects, restore dental alveolar ridges, and facilitate sinus-lift procedures. The purpose of this study was to analyze whether a combination of PRP and Bio-Oss would enhance bone regeneration better than either material alone. PRP and/or Bio-Oss were administered in an 8-mm critical-size defect (CSD) rat calvarial model of bone defect between 2 polytetrafluoroethylene membranes to prevent soft tissue incursion. Eight weeks after the induction of the CSD, histologic sections were stained with hematoxylin and eosin stain and analyzed via light microscopy. Qualitative analyses revealed new bone regeneration in all 4 groups. The Bio-Oss and PRP plus Bio-Oss groups demonstrated greater areas of closure in the defects than the control or PRP-only groups because of the space-maintaining ability of Bio-Oss. The groups grafted with Bio-Oss showed close contact with new bone growth throughout the defects, suggesting a stronger graft. The use of PRP alone or in combination with Bio-Oss, however, did not appear to enhance osseous regeneration at 8 weeks. Areas grafted with Bio-Oss demonstrated greater space-maintaining capacity than controls, and PRP was an effective vehicle for placement of the Bio-Oss. However, at 8 weeks this study was unable to demonstrate a significant advantage of using PRP plus Bio-Oss over using Bio-Oss alone.

Effect of Platelet-Rich Plasma and Fibrin Glue on Healing of Critical-Size Calvarial Bone Defects

2009 ◽  
Vol 20 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Kemal Findikcioglu ◽  
Fulya Findikcioglu ◽  
Reha Yavuzer ◽  
Cigdem Elmas ◽  
Kenan Atabay
Keyword(s):  
Fibrin Glue ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Bone Defects ◽  
Calvarial Bone
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