Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging

2012 ◽  
Vol 372 (1) ◽  
pp. 239-244 ◽  
Author(s):  
Aili Zhang ◽  
Yu Tu ◽  
Songbing Qin ◽  
Yan Li ◽  
Juying Zhou ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Gold Nanoclusters ◽  
X Ray ◽  
Dual Modality ◽  
Dual Modality Imaging

Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging

Biomaterials ◽  
2011 ◽  
Vol 32 (26) ◽  
pp. 6155-6163 ◽  
Author(s):  
Zhe Liu ◽  
Twan Lammers ◽  
Josef Ehling ◽  
Stanley Fokong ◽  
Jörg Bornemann ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticle ◽  
Dual Modality ◽  
Oxide Nanoparticle ◽  
Dual Modality Imaging

scholarly journals Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging

2013 ◽  
Vol 8 (1) ◽  
pp. 170 ◽  
Author(s):  
Jing Lin ◽  
Zhijun Zhou ◽  
Zhiming Li ◽  
Chunlei Zhang ◽  
Xiansong Wang ◽  
...  
Keyword(s):  
Gold Nanoclusters ◽  
One Pot ◽  
Dual Modality ◽  
One Pot Synthesis ◽  
Dual Modality Imaging

Rational Design of Magnetic Nanorattles as Contrast Agents for Ultrasound/Magnetic Resonance Dual-Modality Imaging

2014 ◽  
Vol 6 (15) ◽  
pp. 12581-12587 ◽  
Author(s):  
Peng Yang ◽  
Fang Wang ◽  
Xianfu Luo ◽  
Yuting Zhang ◽  
Jia Guo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Rational Design ◽  
Dual Modality ◽  
Dual Modality Imaging

Self-assembled microbubbles as contrast agents for ultrasound/magnetic resonance dual-modality imaging

2015 ◽  
Vol 24 ◽  
pp. 266-278 ◽  
Author(s):  
Sheng Song ◽  
Heze Guo ◽  
Zequan Jiang ◽  
Yuqing Jin ◽  
Ying Wu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Dual Modality ◽  
Dual Modality Imaging ◽  
Self Assembled

scholarly journals Synthesis of Exosome-Based Fluorescent Gold Nanoclusters for Cellular Imaging Applications

2021 ◽  
Vol 22 (9) ◽  
pp. 4433
Author(s):  
Eun Sung Lee ◽  
Byung Seok Cha ◽  
Seokjoon Kim ◽  
Ki Soo Park
Keyword(s):  
Photoelectron Spectroscopy ◽  
Low Cost ◽  
Stokes Shift ◽  
Gold Nanoclusters ◽  
Human Colon ◽  
Cellular Imaging ◽  
Metal Nanoclusters ◽  
Human Colon Cancer ◽  
X Ray ◽  
High Concentrations

In recent years, fluorescent metal nanoclusters have been used to develop bioimaging and sensing technology. Notably, protein-templated fluorescent gold nanoclusters (AuNCs) are attracting interest due to their excellent fluorescence properties and biocompatibility. Herein, we used an exosome template to synthesize AuNCs in an eco-friendly manner that required neither harsh conditions nor toxic chemicals. Specifically, we used a neutral (pH 7) and alkaline (pH 11.5) pH to synthesize two different exosome-based AuNCs (exo-AuNCs) with independent blue and red emission. Using field-emission scanning electron microscopy, energy dispersive X-ray microanalysis, nanoparticle tracking analysis, and X-ray photoelectron spectroscopy, we demonstrated that AuNCs were successfully formed in the exosomes. Red-emitting exo-AuNCs were found to have a larger Stokes shift and a stronger fluorescence intensity than the blue-emitting exo-AuNCs. Both exo-AuNCs were compatible with MCF-7 (human breast cancer), HeLa (human cervical cancer), and HT29 (human colon cancer) cells, although blue-emitting exo-AuNCs were cytotoxic at high concentrations (≥5 mg/mL). Red-emitting exo-AuNCs successfully stained the nucleus and were compatible with membrane-staining dyes. This is the first study to use exosomes to synthesize fluorescent nanomaterials for cellular imaging applications. As exosomes are naturally produced via secretion from almost all types of cell, the proposed method could serve as a strategy for low-cost production of versatile nanomaterials.

Sign in / Sign up

Export Citation Format

Share Document