scholarly journals Stimulation of β2-adrenergic receptor increases CFTR function and decreases ATP levels in murine hematopoietic stem/progenitor cells

2015 ◽  
Vol 14 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Teresa Trotta ◽  
Lorenzo Guerra ◽  
Donatella Piro ◽  
Maria d'Apolito ◽  
Claudia Piccoli ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Adrenergic Receptor ◽  
Hematopoietic Stem ◽  
Atp Levels ◽  
Β2 Adrenergic Receptor ◽  
Stimulation Of

Selected Contribution: Long-term effects of β2-adrenergic receptor stimulation on alveolar fluid clearance in mice

2002 ◽  
Vol 93 (5) ◽  
pp. 1875-1880 ◽  
Author(s):  
C. Sartori ◽  
X. Fang ◽  
D. W. McGraw ◽  
P. Koch ◽  
M. E. Snider ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Fluid Transport ◽  
Alveolar Fluid Clearance ◽  
Camp Production ◽  
Long Term Effects ◽  
Agonist Stimulation ◽  
Β2 Adrenergic Receptor ◽  
Stimulation Of ◽  
Alveolar Edema

Stimulation of active fluid transport with β-adrenergic receptor (βAR) agonists can accelerate the resolution of alveolar edema. However, chronic βAR-agonist administration may cause βAR desensitization and downregulation that may impair physiological responsiveness to βAR-agonist stimulation. Therefore, we measured baseline and terbutaline- (10−3 M) stimulated alveolar fluid clearance in mice that received subcutaneously (miniosmotic pumps) either saline or albuterol (2 mg · kg−1 · day−1) for 1, 3, or 6 days. Continuous albuterol administration increased plasma albuterol levels (10−5 M), an effect that was associated with 1) a significant decrease in βAR density and 2) attenuation, but not ablation, of maximal terbutaline-induced cAMP production. Forskolin-mediated cAMP-release was unaffected. Continuous albuterol infusion stimulated alveolar fluid clearance on day 1 but did not increase alveolar fluid clearance on days 3 and 6. However, terbutaline-stimulated alveolar fluid clearance in albuterol-treated mice was not reduced compared with saline-treated mice. Despite significant reductions in βAR density and agonist-mediated cAMP production by long-term βAR-agonist exposure, maximal βAR-agonist-mediated increase in alveolar fluid clearance is not diminished in mice.

scholarly journals Direct Toll-Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Macrophages

Stem Cells ◽  
2012 ◽  
Vol 30 (7) ◽  
pp. 1486-1495 ◽  
Author(s):  
Javier Megías ◽  
Alberto Yáñez ◽  
Silvia Moriano ◽  
José-Enrique O'Connor ◽  
Daniel Gozalbo ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Toll Like Receptor ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells ◽  
Stimulation Of

scholarly journals Stimulation of the B Cell Receptor, CD86 (B7-2), and the β2-Adrenergic Receptor Intrinsically Modulates the Level of IgG1 and IgE Produced per B Cell

2000 ◽  
Vol 165 (2) ◽  
pp. 680-690 ◽  
Author(s):  
Deborah J. Kasprowicz ◽  
Adam P. Kohm ◽  
Michael T. Berton ◽  
Andrezj J. Chruscinski ◽  
Arlene Sharpe ◽  
...  
Keyword(s):  
B Cell ◽  
Adrenergic Receptor ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Β2 Adrenergic Receptor ◽  
Stimulation Of
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