scholarly journals Using metal-catalyzed oxidation reactions and mass spectrometry to identify amino acid residues within 10 Å of the metal in Cu-binding proteins

2006 ◽  
Vol 17 (11) ◽  
pp. 1552-1559 ◽  
Author(s):  
Juma D. Bridgewater ◽  
Jihyeon Lim ◽  
Richard W. Vachet
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Binding Proteins ◽  
Amino Acid Residues ◽  
Oxidation Reactions ◽  
Identify Amino Acid ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation

scholarly journals Scleroderma Autoantigens Are Uniquely Fragmented by Metal-catalyzed Oxidation Reactions: Implications for Pathogenesis

1997 ◽  
Vol 185 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Livia Casciola-Rosen ◽  
Fredrick Wigley ◽  
Antony Rosen
Keyword(s):  
Reactive Oxygen Species ◽  
Ischemia Reperfusion ◽  
Reactive Oxygen ◽  
Autoimmune Response ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Oxidation Reactions ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation

The observation that revelation of immunocryptic epitopes in self antigens may initiate the autoimmune response has prompted the search for processes which induce novel fragmentation of autoantigens as potential initiators of autoimmunity. The reversible ischemia reperfusion which characterizes scleroderma has focused attention on reactive oxygen species as molecules which might induce autoantigen fragmentation. We demonstrate that several of the autoantigens targeted in diffuse scleroderma are uniquely susceptible to cleavage by reactive oxygen species, in a metal-dependent manner. Multiple features of the fragmentation reaction and its inhibition indicate that these autoantigens possess metal-binding sites, which focus metal-catalyzed oxidation reactions (and consequent fragmentation) to specific regions of the antigens. These data suggest that the autoantibody response in scleroderma is the immune marker of unique protein fragmentation, induced by ischemia reperfusion in the presence of appropriate metals, and focus attention on abnormal metal status as a potential pathogenic principle in this disease.

scholarly journals Metal Catalyzed Oxidation Reactions of Alkenes Using Eco-Friendly Oxidants

2021 ◽  
Author(s):  
Jay Soni ◽  
Pankaj Teli ◽  
Nusrat Sahiba ◽  
Ayushi Sethiya ◽  
Shikha Agarwal
Keyword(s):  
Organic Synthesis ◽  
Low Cost ◽  
Oxidation Reactions ◽  
Reaction Condition ◽  
Solid Waste Generation ◽  
Metal Catalyzed Oxidation ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation ◽  
New Strategies

Oxidation of alkenes is an important reaction in academia, industry and science as it is used to develop epoxides, carbonyls, allylic compounds, 1,2-diols, etc. Metal catalyzed oxidation of alkenes has aroused as a significant tool in modern organic synthesis. Several techniques are available; however some of them suffer from few shortcomings viz. high cost, toxic nature, harsh reaction condition, solid waste generation, etc. In view of these drawbacks, green oxidants i.e. O2, H2O2, TBHP, etc. have shown noteworthy prospects due to their nature, low cost, high atom economy and high sustainability in metal catalyzed reactions. This chapter highlights the metal catalyzed green oxidation of alkenes and shall provide new strategies for the functionalization and transformation of alkenes.

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