Investigation of ligand interactions with human RXRα by hydrogen/deuterium exchange and mass spectrometry

Xuguang Yan; Max L. Deinzer; Michael I. Schimerlik; David Broderick; Mark E. Leid; Marcia I. Dawson

doi:10.1016/j.jasms.2006.05.016

Investigation of ligand interactions with human RXRα by hydrogen/deuterium exchange and mass spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1016/j.jasms.2006.05.016 ◽

2006 ◽

Vol 17 (11) ◽

pp. 1510-1517 ◽

Cited By ~ 10

Author(s):

Xuguang Yan ◽

Max L. Deinzer ◽

Michael I. Schimerlik ◽

David Broderick ◽

Mark E. Leid ◽

...

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Ligand Interactions ◽

Hydrogen Deuterium

Download Full-text

Hydrogen/Deuterium Exchange Mass Spectrometry for Investigating Protein-Ligand Interactions

Assay and Drug Development Technologies ◽

10.1089/154065804322966342 ◽

2004 ◽

Vol 2 (1) ◽

pp. 81-91 ◽

Cited By ~ 44

Author(s):

Ricardo A. Garcia ◽

Dennis Pantazatos ◽

Francisco J. Villarreal

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Synergistic Structural Information from Covalent Labeling and Hydrogen–Deuterium Exchange Mass Spectrometry for Protein–Ligand Interactions

Analytical Chemistry ◽

10.1021/acs.analchem.9b04257 ◽

2019 ◽

Vol 91 (23) ◽

pp. 15248-15254 ◽

Cited By ~ 4

Author(s):

Tianying Liu ◽

Patanachai Limpikirati ◽

Richard W. Vachet

Keyword(s):

Mass Spectrometry ◽

Structural Information ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Covalent Labeling ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac051294f ◽

2006 ◽

Vol 78 (4) ◽

pp. 1005-1014 ◽

Cited By ~ 202

Author(s):

Michael J. Chalmers ◽

Scott A. Busby ◽

Bruce D. Pascal ◽

Yuanjun He ◽

Christopher L. Hendrickson ◽

...

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Protein-Protein and Protein-Ligand Interactions Studied by Hydrogen/Deuterium Exchange Mass Spectrometry

Mass Spectrometry of Biological Materials ◽

10.1201/9781482269987-20 ◽

1998 ◽

pp. 385-404

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen–Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein–Ligand Interactions

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.6b09358 ◽

2016 ◽

Vol 121 (15) ◽

pp. 3493-3501 ◽

Cited By ~ 22

Author(s):

Daniel J. Saltzberg ◽

Howard B. Broughton ◽

Riccardo Pellarin ◽

Michael J. Chalmers ◽

Alfonso Espada ◽

...

Keyword(s):

Mass Spectrometry ◽

Bayesian Approach ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Quantitative Interpretation ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Mass Spectrometry Application

Download Full-text

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

Expert Review of Proteomics ◽

10.1586/epr.10.109 ◽

2011 ◽

Vol 8 (1) ◽

pp. 43-59 ◽

Cited By ~ 150

Author(s):

Michael J Chalmers ◽

Scott A Busby ◽

Bruce D Pascal ◽

Graham M West ◽

Patrick R Griffin

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Mass Spectrometry Analysis ◽

Hydrogen Deuterium Exchange ◽

Spectrometry Analysis ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Mapping Protein–Ligand Interactions with Proteolytic Fragmentation, Hydrogen/Deuterium Exchange-Mass Spectrometry

Methods in Enzymology - Isotope Labeling of Biomolecules - Applications ◽

10.1016/bs.mie.2015.08.010 ◽

2016 ◽

pp. 357-404 ◽

Cited By ~ 30

Author(s):

Elyssia S. Gallagher ◽

Jeffrey W. Hudgens

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2014.06.007 ◽

2014 ◽

Vol 1844 (9) ◽

pp. 1684-1693 ◽

Cited By ~ 16

Author(s):

Liping Yang ◽

David Broderick ◽

Yuan Jiang ◽

Victor Hsu ◽

Claudia S. Maier

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hypolipidemic Agent ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

Download Full-text