Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry

Michael J. Chalmers; Scott A. Busby; Bruce D. Pascal; Yuanjun He; Christopher L. Hendrickson; Alan G. Marshall; Patrick R. Griffin

doi:10.1021/ac051294f

Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac051294f ◽

2006 ◽

Vol 78 (4) ◽

pp. 1005-1014 ◽

Cited By ~ 202

Author(s):

Michael J. Chalmers ◽

Scott A. Busby ◽

Bruce D. Pascal ◽

Yuanjun He ◽

Christopher L. Hendrickson ◽

...

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen/Deuterium Exchange Mass Spectrometry for Investigating Protein-Ligand Interactions

Assay and Drug Development Technologies ◽

10.1089/154065804322966342 ◽

2004 ◽

Vol 2 (1) ◽

pp. 81-91 ◽

Cited By ~ 44

Author(s):

Ricardo A. Garcia ◽

Dennis Pantazatos ◽

Francisco J. Villarreal

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Synergistic Structural Information from Covalent Labeling and Hydrogen–Deuterium Exchange Mass Spectrometry for Protein–Ligand Interactions

Analytical Chemistry ◽

10.1021/acs.analchem.9b04257 ◽

2019 ◽

Vol 91 (23) ◽

pp. 15248-15254 ◽

Cited By ~ 4

Author(s):

Tianying Liu ◽

Patanachai Limpikirati ◽

Richard W. Vachet

Keyword(s):

Mass Spectrometry ◽

Structural Information ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Covalent Labeling ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Protein-Protein and Protein-Ligand Interactions Studied by Hydrogen/Deuterium Exchange Mass Spectrometry

Mass Spectrometry of Biological Materials ◽

10.1201/9781482269987-20 ◽

1998 ◽

pp. 385-404

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

Expert Review of Proteomics ◽

10.1586/epr.10.109 ◽

2011 ◽

Vol 8 (1) ◽

pp. 43-59 ◽

Cited By ~ 150

Author(s):

Michael J Chalmers ◽

Scott A Busby ◽

Bruce D Pascal ◽

Graham M West ◽

Patrick R Griffin

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Mass Spectrometry Analysis ◽

Hydrogen Deuterium Exchange ◽

Spectrometry Analysis ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Mapping Protein–Ligand Interactions with Proteolytic Fragmentation, Hydrogen/Deuterium Exchange-Mass Spectrometry

Methods in Enzymology - Isotope Labeling of Biomolecules - Applications ◽

10.1016/bs.mie.2015.08.010 ◽

2016 ◽

pp. 357-404 ◽

Cited By ~ 30

Author(s):

Elyssia S. Gallagher ◽

Jeffrey W. Hudgens

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2014.06.007 ◽

2014 ◽

Vol 1844 (9) ◽

pp. 1684-1693 ◽

Cited By ~ 16

Author(s):

Liping Yang ◽

David Broderick ◽

Yuan Jiang ◽

Victor Hsu ◽

Claudia S. Maier

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hypolipidemic Agent ◽

Ligand Interactions ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Cited By ~ 4

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Continuous Feeding

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Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry

Journal of Structural Biology ◽

10.1016/j.jsb.2015.04.006 ◽

2015 ◽

Vol 190 (2) ◽

pp. 250-259 ◽

Cited By ~ 11

Author(s):

Dong Kyun Kim ◽

Youngjoo Yun ◽

Hee Ryung Kim ◽

Min-Duk Seo ◽

Ka Young Chung

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Analytica Chimica Acta ◽

10.1016/j.aca.2016.08.006 ◽

2016 ◽

Vol 940 ◽

pp. 8-20 ◽

Cited By ~ 36

Author(s):

Bin Deng ◽

Cristina Lento ◽

Derek J. Wilson

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text