scholarly journals Ionic liquid matrix-induced metastable decay of peptides and oligonucleotides and stabilization of phospholipids in MALDI FTMS analyses

2005 ◽  
Vol 16 (12) ◽  
pp. 2000-2008 ◽  
Author(s):  
Jeffrey J. Jones ◽  
S. Mariccor A. B. Batoy ◽  
Charles L. Wilkins ◽  
Rohana Liyanage ◽  
Jackson O. Lay
Keyword(s):  
Ionic Liquid ◽  
Liquid Matrix ◽  
Metastable Decay

A cool and high salt-tolerant ionic liquid matrix for preferential ionization of phosphopeptides by negative ion MALDI-MS

2017 ◽  
Vol 41 (20) ◽  
pp. 12241-12249 ◽  
Author(s):  
Ling Ling ◽  
Chunsheng Xiao ◽  
Liyan Jiang ◽  
Sheng Wang ◽  
Ying Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
High Salt ◽  
Maldi Ms ◽  
Negative Ion ◽  
Liquid Matrix ◽  
Salt Tolerant

An optimized ILM G3THAP/PA matrix significantly improved the detection of phosphopeptides by negative ion MALDI-MS compared with using 3-AQ/CHCA/ADP and DHB/PA matrices.

scholarly journals Combination of Microwave-Assisted Girard Derivatization with Ionic Liquid Matrix for Sensitive MALDI-TOF MS Analysis of Human Serum N-Glycans

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hoa Thi Le ◽  
Kyu H. Park ◽  
Woong Jung ◽  
Hyung Soon Park ◽  
Tae Woo Kim
Keyword(s):  
Ionic Liquid ◽  
Human Serum ◽  
Solid Phase ◽  
Liquid Matrix ◽  
Dihydroxybenzoic Acid ◽  
Established Method ◽  
Maldi Tof Ms ◽  
Microwave Assisted ◽  
Maldi Tof ◽  
Tof Ms

We developed a new method for MALDI-TOF MS detection of N-glycans derived from human serum. The synergistic combination of microwave-assisted Girard T derivatization, solid-phase extraction desalting, and an ionic liquid matrix (2, 5-dihydroxybenzoic acid/aniline) (GT-SPE-DHB/An) allowed of more sensitive N-glycans detection than a conventional ionic liquid matrix in MALDI-TOF MS. The superior sensitivity of our method was confirmed by the number of assigned N-glycans in 900–2,000 m/z range. Using our GT-SPE-DHB/An method, we were successfully able to assign 31 glycans. However, with the established method, i.e., DHB/An method, only 15 glycans were assigned. To the best of our knowledge, this GT-SPE-DHB/An method is the first to combine cationic derivatization of N-glycan and ionic liquid matrix for N-glycan analysis in MALDI-TOF MS.

Evidence of supercoolable nanoscale water clusters in an amorphous ionic liquid matrix

2021 ◽  
Vol 155 (17) ◽  
pp. 174501
Author(s):  
Florian Pabst ◽  
Jennifer Kraus ◽  
Sebastian Kloth ◽  
Elisa Steinrücken ◽  
Margarita Kruteva ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Water Clusters ◽  
Liquid Matrix
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