Vitamin D Deficiency: An Increasing Concern in Peripheral Arterial Disease

2010 ◽  
Vol 11 (5) ◽  
pp. 308-311 ◽  
Author(s):  
Vamsi C. Gaddipati ◽  
Reena Kuriacose ◽  
Rebecca Copeland ◽  
Beth A. Bailey ◽  
Alan N. Peiris
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation

2019 ◽  
Vol 20 (19) ◽  
pp. 4907 ◽  
Author(s):  
Smriti Murali Krishna
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Experimental Studies ◽  
Arterial Disease ◽  
Current Evidence ◽  
Peripheral Arterial

Atherosclerotic occlusive diseases and aneurysms that affect large and medium-sized arteries outside the cardiac and cerebral circulation are collectively known as peripheral arterial disease (PAD). With a rise in the rate of aging population worldwide, the number of people diagnosed with PAD is rapidly increasing. The micronutrient vitamin D is an important steroid hormone that acts on many crucial cellular mechanisms. Experimental studies suggest that optimal levels of vitamin D have beneficial effects on the heart and blood vessels; however, high vitamin D concentrations have been implicated in promoting vascular calcification and arterial stiffness. Observations from various clinical studies shows that deficiency of vitamin D has been associated with a greater risk of PAD. Epidemiological studies have often reported an inverse relation between circulating vitamin D status measured in terms of 25-hydroxivitamin D [25(OH)D] levels and increased cardiovascular disease risk; however, randomized controlled trials did not show a consistent positive effect of vitamin D supplementation on cardiovascular disease risk or events. Even though PAD shares all the major risk factors with cardiovascular diseases, the effect of vitamin D deficiency in PAD is not clear. Current evidence suggests a strong role of vitamin D in promoting genomic and epigenomic changes. This review summarises the current literature that supports the notion that vitamin D deficiency may promote PAD formation. A better understanding of underlying pathological mechanisms will open up new therapeutic possibilities which is the main unmet need in PAD management. Furthermore, epigenetic evidence shows that a more holistic approach towards PAD prevention that incorporates a healthy lifestyle, adequate exercise and optimal nutrition may be more effective in protecting the genome and maintaining a healthy vasculature.

scholarly journals Association of Vitamin D Deficiency With Peripheral Arterial Disease: A Meta-Analysis of Literature Studies

2018 ◽  
Vol 103 (6) ◽  
pp. 2107-2115 ◽  
Author(s):  
Gabriella Iannuzzo ◽  
Francesco Forte ◽  
Roberta Lupoli ◽  
Matteo Nicola Dario Di Minno
Keyword(s):  
Vitamin D ◽  
Peripheral Arterial Disease ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Vitamin D Deficiency May Not Be an Independent Risk Factor for Peripheral Arterial Disease in Middle-Aged and Elderly Patients with Type 2 Diabetes in China

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yan Wang ◽  
Tongbao Feng ◽  
Hongxing Zhou ◽  
Kefeng Lu ◽  
Yang Bai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Duration ◽  
Arterial Disease ◽  
Regression Analyses ◽  
Middle Aged ◽  
Hba1c Control ◽  
Peripheral Arterial ◽  
The Relationship

Background. Vitamin D deficiency can lead to the increased severity and prevalence of metabolic disorders. However, the relationship between levels of 25-hydroxyvitamin D (25(OH)D) and peripheral arterial disease (PAD) is controversial. Therefore, the purpose of our study was to explore the relationship between 25(OH)D levels and PAD in middle-aged and elderly type 2 diabetes mellitus (T2DM) patients in China. Methods. In this study, a total of 183 patients with T2DM were enrolled and categorized into groups with or without PAD. Clinical and biochemical parameters were assessed, and a Pearson analysis was used to identify a possible association between levels of 25(OH)D and glycated hemoglobin (HbA1c). Some biochemical parameters were also assessed in the T2DM patients with PAD according to vitamin D status. Interactions were also explored among HbA1c control, 25(OH)D levels, and PAD. The possible risk factors for PAD were measured by multivariable logistic regression analyses. Results. Firstly, the parameters including age, HbA1c, and disease duration between T2DM and T2DM+PAD groups showed significantly different. In addition, the frequency of smoking in the group of T2DM patients was significantly less than that in the T2DM patients with the PAD group, while the frequency of well-controlled HbA1c in the patients with T2DM was significantly higher. There is a trend that the levels of 25(OH)D and HbA1c are correlated, but no interactions among vitamin D deficiency, HbA1c control, and PAD were found. However, HbA1c significantly differed between groups with vitamin D deficiency and insufficiency in the T2DM patients with PAD. According to the multivariate logistic regression analyses, the PAD risk factors of T2DM patients were family history of diabetes, smoking, age, disease duration, HbA1c, and LDL. Conclusions. The findings demonstrate that the deficiency of vitamin D level is not related to PAD, but HbA1c may be linked to the presence of PAD in middle-aged and elderly patients with T2DM in China.

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