scholarly journals Bronchial Provocation Testing for the Identification of Exercise-Induced Bronchoconstriction

2020 ◽  
Vol 8 (7) ◽  
pp. 2156-2164 ◽  
Author(s):  
John D. Brannan ◽  
Pascale Kippelen
Keyword(s):  
Provocation Testing ◽  
Exercise Induced ◽  
Bronchial Provocation

Bronchial provocation testing does not detect exercise-induced laryngeal obstruction

2016 ◽  
Vol 54 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Emil Schwarz Walsted ◽  
James H. Hull ◽  
Asger Sverrild ◽  
Celeste Porsbjerg ◽  
Vibeke Backer
Keyword(s):  
Laryngeal Obstruction ◽  
Provocation Testing ◽  
Exercise Induced ◽  
Bronchial Provocation

Circulating Histamine and Neutrophil Chemotactic Activity During Allergen-Induced Asthma: The Effect of Inhaled Antihistamines and Anti-Allergic Compounds

1985 ◽  
Vol 69 (1) ◽  
pp. 63-69 ◽  
Author(s):  
D. J. R. Morgan ◽  
I. Moodley ◽  
D. R. Cundell ◽  
B. D. Sheinman ◽  
W. Smart ◽  
...  
Keyword(s):  
Airflow Obstruction ◽  
Isotonic Saline ◽  
Forced Expiratory Volume ◽  
Chemotactic Activity ◽  
Boyden Chamber ◽  
Plasma Histamine ◽  
Double Blind ◽  
Provocation Testing ◽  
Bronchial Provocation ◽  
Neutrophil Chemotactic Activity

1. Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT). 2. Single doses of inhaled sodium cromoglycate (SCG; 20 mg), clemastine (0.5 mg), ketotifen (0.5 mg) and isotonic saline (0.9% NaCl) placebo were administered 30 min before bronchial provocation testing in random order and double-blind. 3. The airflow obstruction after BPT was monitored by measurement of forced expiratory volume in 1s (FEV1). Plasma histamine was measured by the double-isotope radioenzymatic assay and S-NCA by a modified Boyden chamber technique. 4. A highly significant decrease in FEV1 after BPT occurred on the placebo pre-treatment visit (P < 0.001). Prior administration of inhaled SCG, clemastine and ketotifen significantly reduced the decrease in airflow obstruction seen after BPT when compared with placebo treatment (P < 0.01, P < 0.02, P < 0.05 respectively). 5. No significant alteration in plasma histamine was detected during allergen-induced airflow obstruction. 6. Levels of S-NCA were significantly higher 5, 10 and 15 min after BPT when compared with the pre-challenge level (P < 0.01, P < 0.01, P < 0.001 respectively). These levels were not significantly decreased when airflow obstruction was inhibited by the prior inhalation of SCG, clemastine or ketotifen.

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