Improvements in Cardiovascular and Inflammatory Markers after a Low Glycemic Load Meal Replacement and High Dose Fish Oil Supplementation Program for Obese Adults Considering Bariatric Surgery

2006 ◽  
Vol 106 (8) ◽  
pp. A24
Author(s):  
H.L. Hutchins ◽  
D. Bruner ◽  
E. Anderson ◽  
B. Sears
2010 ◽  
Vol 42 ◽  
pp. 764-765
Author(s):  
Robert A. Standley ◽  
Christopher C. Cheatham ◽  
Michael G. Miller ◽  
Timothy J. Michael ◽  
Robert J. Baker ◽  
...  

2009 ◽  
Vol 103 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Nicholas J. Sjoberg ◽  
Catherine M. Milte ◽  
Jonathan D. Buckley ◽  
Peter R. C. Howe ◽  
Alison M. Coates ◽  
...  

Heart rate (HR) variability and large arterial compliance can be improved using fish oils. DHA, a component of fish oil, has cardiovascular health benefits, but its effect on HR variability (HRV) and arterial compliance is yet to be quantified. Sixty-seven overweight or obese adults (thirty-six males and thirty-one females; 53 (sem 2) year; BMI 31·7 (sem 1·1) kg/m2) were randomly allocated to consume either 6 g/d sunola oil (control; n 17), fish oil (260 mg DHA+60 mg EPA per g) at doses of 2 g/d (n 16), 4 g/d (n 17) or 6 g/d (n 17). Blood pressure, HR and compliance of large and small arteries were measured while supine at baseline and after 12 weeks in all participants, and HRV was assessed in a subgroup of forty-six participants. There was no effect of fish oil on blood pressure, small artery compliance or HR. However, the low frequency:high frequency ratio of HRV decreased with increasing doses of fish oil (r − 0·34, P = 0·02), while large artery compliance increased (r 0·34, P = 0·006). Moreover, the changes in these biomarkers were significantly correlated (r − 0·31, P = 0·04) and may reflect fish oil-induced improvements in arterial function and cardiac autonomic regulation.


2012 ◽  
Vol 32 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Anders Gammelmark ◽  
Trine Madsen ◽  
Kim Varming ◽  
Søren Lundbye-Christensen ◽  
Erik B. Schmidt

2020 ◽  
Vol 8 ◽  
pp. 2050313X2095297 ◽  
Author(s):  
Shi-Ying Li ◽  
Kaoru Fujinami ◽  
Sheila G Crewther ◽  
Yan-Ling Long ◽  
Hong-Xuan Lie ◽  
...  

Macular hemorrhage can occur spontaneously and repeatedly without choroidal neovascularization or other known lesions associated with myopia. We report a case of repeated myopic macular hemorrhage following fish oil supplementation. A 32-year-old male was referred with newly acquired paracentral scotoma in the left eye. Serial retinal imaging, including fundus photography, fluorescein angiography, and spectral-domain optical coherence tomography were performed. Fundus photography and fluorescein angiography showed a subtle red-colored lesion nasal to the fovea. Optical coherence tomography showed a dome shaped elevation in the ellipsoid zone and interdigitation zone in the left eye. No known ocular risk factors for macular hemorrhage, such as choroidal neovascularization, lacquer cracks, Fuch’s spot or choroid thinning or keratoconus were observed. After 2 months without any treatment, the left eye lesion disappeared. However 2 weeks later, another newly developed red-colored lesion close to the left fovea was observed. At that moment, the detailed medical history revealed that the patient had been regularly taking a high dose of commercially available fish oil supplement beginning one month before the first macular hemorrhage. After discontinuation of the fish oil, the second left hemorrhage resolved gradually over the following 8 weeks. No recurrent hemorrhages have been detected at the 12 months follow-up visits. Our observations suggest that the relative value of nutritional supplementation with high doses of fish oil should be cautioned in patients with repetitive retinal hemorrhage.


Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1283 ◽  
Author(s):  
Juan Henao Agudelo ◽  
Leandro Baia ◽  
Milene Ormanji ◽  
Amandda Santos ◽  
Juliana Machado ◽  
...  

Background: Chronic kidney disease and inflammation promote loss of Klotho expression. Given the well-established anti-inflammatory effects of omega-3 fatty acids, we aimed to investigate the effect of fish oil supplementation in a model of CKD. Methods: Male C57BL/6 mice received supplementation with an adenine-enriched diet (AD, n = 5) or standard diet (CTL, n = 5) for 10 days. Two other experimental groups were kept under the adenine diet for 10 days. Following adenine withdrawal on the 11th day, the animals returned to a standard diet supplemented with fish oil (Post AD-Fish oil, n = 9) or not (Post AD-CTL, n = 9) for an additional period of 7 days. Results: Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1β (IL-1β), in addition to prominent renal fibrosis and reduced renal Klotho gene expression compared to the control. Post AD-Fish oil animals demonstrated a significant reduction of IL-6, C-X-C motif chemokine 9 (CXCL9), and IL-1β compared to Post AD-CTL animals. However, serum creatinine, renal fibrosis, and Klotho were not significantly different in the fish oil-treated group. Furthermore, renal histomorphological changes such as tubular dilatation and interstitial infiltration persisted despite treatment. Conclusions: Fish oil supplementation reduced renal pro-inflammatory markers but was not able to restore renal function nor Klotho expression in an adenine-induced CKD model.


2018 ◽  
Vol 102 ◽  
pp. S599
Author(s):  
Ida Robertsen ◽  
Anders Åsberg ◽  
Karsten Midtvedt ◽  
Nils Tore Vethe ◽  
Anders Hartmann ◽  
...  

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