scholarly journals White matter abnormalities predict residual negative self-referential thinking following treatment of late-life depression with escitalopram: A preliminary study

2019 ◽  
Vol 243 ◽  
pp. 62-69 ◽  
Author(s):  
Lindsay W. Victoria ◽  
George S. Alexopoulos ◽  
Irena Ilieva ◽  
Aliza T. Stein ◽  
Matthew J. Hoptman ◽  
...  
Keyword(s):  
White Matter ◽  
Late Life ◽  
Late Life Depression ◽  
White Matter Abnormalities ◽  
Preliminary Study

scholarly journals Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities

NeuroImage ◽  
2012 ◽  
Vol 60 (4) ◽  
pp. 2182-2190 ◽  
Author(s):  
Joseph M. Mettenburg ◽  
Tammie L. Benzinger ◽  
Joshua S. Shimony ◽  
Abraham Z. Snyder ◽  
Yvette I. Sheline
Keyword(s):  
White Matter ◽  
Neuropsychological Testing ◽  
Late Life ◽  
Late Life Depression ◽  
White Matter Abnormalities

Frontal White Matter Microstructure and Treatment Response of Late-Life Depression: A Preliminary Study

2002 ◽  
Vol 159 (11) ◽  
pp. 1929-1932 ◽  
Author(s):  
George S. Alexopoulos ◽  
Dimitris N. Kiosses ◽  
Steven J. Choi ◽  
Christopher F. Murphy ◽  
Kelvin O. Lim
Keyword(s):  
White Matter ◽  
Treatment Response ◽  
Late Life ◽  
Late Life Depression ◽  
White Matter Microstructure ◽  
Frontal White Matter ◽  
Preliminary Study

scholarly journals Vascular lesions and functional limitations among older adults: does depression make a difference?

2014 ◽  
Vol 26 (9) ◽  
pp. 1501-1509 ◽  
Author(s):  
Celia F. Hybels ◽  
Carl F. Pieper ◽  
Lawrence R. Landerman ◽  
Martha E. Payne ◽  
David C. Steffens
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
White Matter ◽  
Functional Impairment ◽  
Functional Limitations ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral White Matter ◽  
Late Life Depression ◽  
Increased Risk

ABSTRACTBackground:The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with functional impairment. These vascular changes are also associated with late life depression, but it is not known if depression is a modifier in the relationship between cerebrovascular changes and functional impairment.Methods:The study sample was 237 older adults diagnosed with major depression and 140 never depressed comparison adults, with both groups assessed at study enrollment. The dependent variable was the number of limitations in basic activities of daily living (ADL), instrumental ADLs, and mobility tasks. The independent variable was the total volume of cerebral white matter lesions or hyperintensities assessed though magnetic resonance imaging.Results:In analyses controlling for age, sex, race, high blood pressure, and cognitive status, a greater volume of WMH was positively associated with the total number of functional limitations as well as the number of mobility limitations among those older adults with late life depression but not among those never depressed, suggesting the association between WMH volume and functional status differs in the presence of late life depression.Conclusions:These findings suggest older patients with both depression and vascular risk factors may be at an increased risk for functional decline, and may benefit from management of both cerebrovascular risk factors and depression.

scholarly journals Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study

2013 ◽  
pp. 1867 ◽  
Author(s):  
Masayuki Tani ◽  
Hideyuki Shimizu ◽  
Minoru Takebayashi ◽  
Hiroaki Tanaka ◽  
Bun Yamagata ◽  
...  
Keyword(s):  
Late Life ◽  
Late Life Depression ◽  
Sigma 1 Receptor ◽  
Receptor Concentration ◽  
Sigma 1 ◽  
Preliminary Study

White matter microstructural abnormalities in late-life depression

2007 ◽  
Vol 19 (4) ◽  
pp. 757-766 ◽  
Author(s):  
Qiong Yang ◽  
Xuebing Huang ◽  
Nan Hong ◽  
Xin Yu
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Late Life ◽  
Middle Frontal Gyrus ◽  
Parahippocampal Gyrus ◽  
Late Life Depression ◽  
White Matter Damage ◽  
Conventional Mri ◽  
Mr Diffusion ◽  
Diffusion Tensor Imaging Dti

Objective: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).Methods: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.Results: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.Conclusion: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.

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