scholarly journals Long-term risk of myocardial infarction and stroke in bipolar I disorder: A population-based Cohort Study

2016 ◽  
Vol 194 ◽  
pp. 120-127 ◽  
Author(s):  
Miguel L. Prieto ◽  
Louis A. Schenck ◽  
Jennifer L. Kruse ◽  
James P. Klaas ◽  
Alanna M. Chamberlain ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Population Based ◽  
Bipolar I Disorder

scholarly journals LONG-TERM RISK OF STROKE IN MYOCARDIAL INFARCTION SURVIVORS: A 30-YEAR POPULATION-BASED NATIONWIDE COHORT STUDY

2016 ◽  
Vol 67 (13) ◽  
pp. 438
Author(s):  
Jens Sundboll ◽  
Erzsebet Horvath-Puho ◽  
Morten Schmidt ◽  
Lars Pedersen ◽  
Victor Henderson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Population Based

scholarly journals Short-term and long-term case-fatality rates for myocardial infarction and ischaemic stroke by socioeconomic position and sex: a population-based cohort study in Sweden, 1990–1994 and 2005–2009

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e026192
Author(s):  
Ninoa Malki ◽  
Sara Hägg ◽  
Sanna Tiikkaja ◽  
Ilona Koupil ◽  
Pär Sparén ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Ischaemic Stroke ◽  
Socioeconomic Position ◽  
Case Fatality ◽  
Population Based ◽  
Targeted Prevention ◽  
Short Term ◽  
General Decline

ObjectiveCase-fatality rates (CFRs) for myocardial infarction (MI) and ischaemic stroke (IS) have decreased over time due to better prevention, medication and hospital care. It is unclear whether these improvements have been equally distributed according to socioeconomic position (SEP) and sex. The aim of this study is to analyse differences in short-term and long-term CFR for MI and IS by SEP and sex between the periods 1990–1994 to 2005–2009 for the entire Swedish population.DesignPopulation-based cohort study based on Swedish national registers.MethodsWe used logistic regression and flexible parametric models to estimate short-term CFR (death before reaching the hospital or on the disease event day) and long-term CFR (1 year case-fatality conditional on surviving short-term) across five distinct SEP groups, as well as CFR differences (CFRDs) between SEP groups for both MI and IS from 1990–1994 to 2005–2009.ResultsOverall short-term CFR for both MI and IS decreased between study periods. For MI, differences in short-term and long-term CFR between the least and most favourable SEP group were generally stable, except in long-term CFR among women; intermediate SEP groups mostly managed to catch up with the most favourable SEP group. For IS, short-term CFRD generally decreased compared with the most favourable group; but long-term CFRD were mostly stable, except for an increase for older subjects.ConclusionDespite a general decline in CFR for MI and IS across all SEP groups and both sexes as well as some reductions in CFRD, we found persistent and even increasing CFRD among the least advantaged SEP groups, older patients and women. We speculate that targeted prevention rather than treatment strategies have the potential to reduce these inequalities.

scholarly journals High visit-to-visit cholesterol variability predicts heart failure and adverse cardiovascular events: a population-based cohort study

2021 ◽  
Author(s):  
Jeffrey Shi Kai Chan ◽  
Danish Iltaf Satti ◽  
Yan Hiu Athena Lee ◽  
Jeremy Man Ho Hui ◽  
Teddy Tai Loy Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cohort Study ◽  
Cardiovascular Mortality ◽  
Cardiovascular Events ◽  
Population Based ◽  
Blood Cholesterol ◽  
Lipid Lowering

Background: Dyslipidaemia is associated with adverse cardiovascular outcomes. However, the long-term prognostic value of visit-to-visit cholesterol variability for the risks of heart failure (HF) is uncertain. We investigated the associations between cholesterol variability and the risk of HF and adverse cardiovascular events. Methods: This retrospective cohort study included patients attending family medicine clinics in Hong Kong during 2000-2003 with follow-up until 2019. Patients with at least three sets of blood cholesterol (low-density (LDL-C) and high-density (HDL-C) lipoprotein cholesterol) levels available at different visits were included. Patients with prior HF, myocardial infarction (MI), use of HF medications, and pregnancy were excluded. Visit-to-visit variability was calculated using standard deviation and coefficient of variation (CV). The primary outcome was HF. The secondary outcomes were cardiovascular mortality, and myocardial infarction. Results: A total of 5662 patients were included (2152 males; mean age 63.3+/-12.4 years; mean follow-up 15.3+/-4.6 years). Higher variability of HDL-C (hazard ratio (HR) for CV: 13.757 [6.261, 30.226], p<0.0001) predicted new-onset HF. Higher variability of LDL-C (HR for CV: 3.885 [1.942, 7.775], p=0.0001) and HDL-C (HR for CV: 39.118 [13.583, 112.657], p<0.0001) predicted higher risk of MI, but not cardiovascular mortality. These associations remained significant in patients without baseline usage of lipid-lowering medication(s) (N=4068), but were all insignificant in patients with baseline usage of lipid-lowering medication(s) (N=1594). Conclusion: Higher visit-to-visit cholesterol variability was varyingly associated with significantly increased long-term risks of HF and adverse cardiovascular events. Such associations may be negated by using lipid-lowering medication(s).

Sign in / Sign up

Export Citation Format

Share Document