Sex differences in long‐term cardiovascular outcomes among patients with acute myocardial infarction: A population‐based retrospective cohort study

2021 ◽  
Vol 75 (5) ◽  
Author(s):  
Shih‐Sheng Chang ◽  
Shih‐Yi Lin ◽  
Jung‐Nien Lai ◽  
Ke‐Wei Chen ◽  
Chiung‐Ray Lu ◽  
...  
Author(s):  
Hyojung Choi ◽  
Joo Yeon Seo ◽  
Jinho Shin ◽  
Bo Youl Choi ◽  
Yu-Mi Kim

Heart failure (HF) is the major mechanism of mortality in acute myocardial infarction (AMI) during early or intermediate post-AMI period. But heart failure is one of the most common long-term complications of AMI. Applied the retrospective cohort study design with nation representative population data, this study traced the incidence of late-onset heart failure since 1 year after newly developed acute myocardial infarction and assessed its risk factors. Methods and Results: Using the Korea National Health Insurance database, 18,328 newly developed AMI patients aged 40 years or older and first hospitalized in 2010 for 3 days or more, were set up as baseline cohort (12,403). The incidence rate of AMI per 100,000 persons was 79.8 overall, and 49.6 for women and 112.3 for men. A total of 2010 (1073 men, 937 women) were newly developed with HF during 6 years following post AMI. Cumulative incidences of HF per 1000 AMI patients for a year at each time period were 37.4 in initial hospitalization, 32.3 in 1 year after discharge, and 8.9 in 1–6 years. The overall and age-specific incidence rates of HF were higher in women than men. For late-onset HF, female, medical aid, pre-existing hypertension, severity of AMI, duration of hospital stay during index admission, reperfusion treatment, and drug prescription pattern including diuretics, affected the occurrence of late-onset HF. Conclusion: With respect to late-onset HF following AMI, appropriate management including hypertension and medical aid program in addition to quality improvement of AMI treatment are required to reduce the risk of late-onset heart failure.


2017 ◽  
Vol 187 (4) ◽  
pp. 786-792 ◽  
Author(s):  
Andrew D Mosholder ◽  
Joo-Yeon Lee ◽  
Esther H Zhou ◽  
Elizabeth M Kang ◽  
Mayurika Ghosh ◽  
...  

2021 ◽  
Author(s):  
Neda Shafiabadi Hassani ◽  
Reza Pirdehghan ◽  
Mohammadhossein Mozafarybazargany ◽  
Roya Sepahvandi ◽  
Zeynab Khodaprast ◽  
...  

Abstract BACKGROUND: We aimed to examine sex differences in mortality after myocardial infarction. METHODS: This retrospective cohort study included all first admitted patients 50 years or older with acute myocardial infarction hospitalized in Rajaei hospital of Karaj city, Iran, between 23th March 2013 and 1th January 2020. Data was retrieved from the hospital information system (HIS) database, including patient’s demographic and socioeconomic characteristics, medical history, acute myocardial infarction (AMI) type, treatment and procedures, and outcome of hospitalization. Simple and multivariate cox regression models were used to assess the association of gender with in-hospital mortality after AMI. Results were presented as crude and adjusted hazard ratios along with their 95% confidence interval (HR (95% CI).RESULTS: Results from the multivariable Cox regression analysis revealed that females had a higher risk of death than males after ST segment Elevation MI (STEMI) (adjusted HR (95% CI): 1.64 (1.15 – 2.36), P=0.007). However, in subgroup analysis by age groups, this significant increased risk was observed only in female patients aged 50 to 64 years than their male counterparts. There was no significant differences between males and females after non-STEMI and unspecified MI.CONCLUSIONS: Based on our findings, women aged 50 to 64 years may be more likely to die during hospitalization after STEMI than men.


PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49113 ◽  
Author(s):  
Pin-Liang Chen ◽  
Wei-Ju Lee ◽  
Wei-Zen Sun ◽  
Yen-Jen Oyang ◽  
Jong-Ling Fuh

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