Interaction between BDNF rs6265 Met allele and low family cohesion is associated with smaller left hippocampal volume in pediatric bipolar disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2015.09.031 ◽

2016 ◽

Vol 189 ◽

pp. 94-97 ◽

Cited By ~ 15

Author(s):

Cristian Patrick Zeni ◽

Benson Mwangi ◽

Bo Cao ◽

Khader M. Hasan ◽

Consuelo Walss-Bass ◽

...

Keyword(s):

Bipolar Disorder ◽

Family Cohesion ◽

Hippocampal Volume ◽

Pediatric Bipolar Disorder ◽

Bdnf Rs6265

Download Full-text

7.3 Interaction Between BDNF rs6265 Met Allele and Low Family Cohesion Is Associated With Smaller Left Hippocampal Volume in Pediatric Bipolar Disorder

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2017.07.614 ◽

2017 ◽

Vol 56 (10) ◽

pp. S311

Author(s):

Cristian Zeni ◽

Iram Kazimi ◽

Benson Mwangi ◽

Bo Cao ◽

Khader Hasan ◽

...

Keyword(s):

Bipolar Disorder ◽

Family Cohesion ◽

Hippocampal Volume ◽

Pediatric Bipolar Disorder ◽

Bdnf Rs6265

Download Full-text

Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Neural Plasticity ◽

10.1155/2015/324825 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Tatiana Lauxen Peruzzolo ◽

Mauricio Anes ◽

Andre de Moura Kohmann ◽

Ana Claudia Mércio Loredo Souza ◽

Ramiro Borges Rodrigues ◽

...

Keyword(s):

Bipolar Disorder ◽

Children And Adolescents ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Hippocampal Volume ◽

Pediatric Bipolar Disorder ◽

Control Group ◽

Drug Naïve ◽

Short Time ◽

The Brain

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents. Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD.

Download Full-text