The role of adverse life events on depression in older adults with ADHD

2015 ◽  
Vol 174 ◽  
pp. 574-579 ◽  
Author(s):  
E.J. Semeijn ◽  
H.C. Comijs ◽  
J.J.S. Kooij ◽  
M. Michielsen ◽  
A.T.F. Beekman ◽  
...  
Author(s):  
Ellen E. Lee ◽  
Baichun Hou ◽  
Ipsit V. Vahia ◽  
Dilip V. Jeste

Late-onset schizophrenia remains an understudied subtype of schizophrenia, despite growing recognition of its impact and distinction from early-onset schizophrenia. This chapter reviews the existing literature on late-onset schizophrenia including beginning with the nomenclature and epidemiology. Then we provide a review of key risk factors and correlates—including genetic risk, sex differences, comorbid sensory loss and physical illness, cognitive and psychiatric symptoms, sociodemographic factors, adverse life events, neuropathology, and inflammation. The chapter ends with clinical issues, including symptoms, differential diagnosis, treatments, and prognosis. Recent studies have examined the role of oestrogen treatments and a new therapy for tardive dyskinesia therapy as well as inflammatory mechanisms in schizophrenia.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S233-S233
Author(s):  
Theresa Gmelin ◽  
Stacy L Andersen ◽  
Robert M Boudreau ◽  
Kaare Christensen ◽  
Mary K Wojczynski ◽  
...  

Abstract Older adults are vulnerable to negative recent life events (RLE) which deplete attentional resources and leads to cognitive exhaustion. Adaptive coping styles reduce perceived stress severity but their role on cognitive tiredness is unknown. We examined RLE and coping styles on perceived mental fatigability (Pittsburgh Fatigability Scale (PFS), 0-50pts, higher=greater fatigability) in the Long Life Family Study (N=1464, age=74.7±12.6, female=57.7%, 43.9% ≥1 major RLE past 6 months, 27.8% higher mental fatigability≥13). All analyses adjusted for family structure, field center, age, and sex. PFS mental scores correlated with all NEO-FFI (60-item, 5-domain) personality traits representing maladaptive (neuroticism r=0.25 p<.0001) and adaptive (conscientiousness r=-0.18, extraversion r=-0.24, p<.00001) coping. Having ≥1RLE was associated with higher mental fatigability (OR=1.4, 95% CI:1.2,1.8, p=.0004); adjustment for neuroticism (OR=1.3, 95% CI:0.9,1.7, p=.06) attenuated the association. Education on adaptive coping may be a modifiable skill that allows older adults to maintain lower perceived mental fatigability despite stressful events.


1997 ◽  
Vol 821 (1 Psychobiology) ◽  
pp. 194-207 ◽  
Author(s):  
CHRISTINE HEIM ◽  
MICHAEL J. OWENS ◽  
PAUL M. PLOTSKY ◽  
CHARLES B. NEMEROFF

2021 ◽  
Vol 10 (6) ◽  
pp. 215
Author(s):  
Keunbok Lee

Although the multidimensionality of core discussion networks has been well established and widely studied, studies of the effects of social support on depression rarely consider the multifaceted aspects of dyadic discussion partner ties. This article proposes defining dyadic social relationships as a construct comprising several tie-level attributes and differentiating multiple forms of support relationships by assessing the configuration pattern of multiple attributes. The current study examines various forms of older adults’ discussion partners and identifies which form of discussion partner relationship is effective at buffering the negative effects of adverse life events on depression symptoms. Results from the University of California Social Network Survey show that older adults’ discussion partners can be classified into five distinct types of dyadic ties: spouse/romantic partners, close neighbors, remote type, social companions, and acquaintances. The discussion network with more close neighbor confidants is more effective at buffering the negative effects of adverse life events. These results offer an alternative way of investigating the differential significance of various social support relationships in mental well-being.


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