Microstructural white matter damage at orbitofrontal areas in borderline personality disorder

2012 ◽  
Vol 139 (2) ◽  
pp. 149-153 ◽  
Author(s):  
José Luis Carrasco ◽  
Kazuhiro Tajima-Pozo ◽  
Marina Díaz-Marsá ◽  
Ana Casado ◽  
Juan J. López-Ibor ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
White Matter ◽  
Personality Disorder ◽  
Borderline Personality ◽  
White Matter Damage

Whole‐brain microstructural white matter alterations in borderline personality disorder patients

2019 ◽  
Vol 13 (2) ◽  
pp. 96-106 ◽  
Author(s):  
Giulia Quattrini ◽  
Moira Marizzoni ◽  
Laura R. Magni ◽  
Silvia Magnaldi ◽  
Mariangela Lanfredi ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
White Matter ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Whole Brain

Microstructural white matter alterations in borderline personality disorder: A minireview

2020 ◽  
Vol 264 ◽  
pp. 249-255 ◽  
Author(s):  
M. Grottaroli ◽  
G. Delvecchio ◽  
C. Bressi ◽  
C. Moltrasio ◽  
J.C. Soares ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
White Matter ◽  
Personality Disorder ◽  
Borderline Personality

Disorder-Specific White Matter Alterations in Adolescent Borderline Personality Disorder

2014 ◽  
Vol 75 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Klaus H. Maier-Hein ◽  
Romuald Brunner ◽  
Kira Lutz ◽  
Romy Henze ◽  
Peter Parzer ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
White Matter ◽  
Personality Disorder ◽  
Borderline Personality

Structural alterations in white-matter tracts connecting (para-)limbic and prefrontal brain regions in borderline personality disorder

2015 ◽  
Vol 45 (15) ◽  
pp. 3171-3180 ◽  
Author(s):  
A. Lischke ◽  
M. Domin ◽  
H. J. Freyberger ◽  
H. J. Grabe ◽  
R. Mentel ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
White Matter ◽  
Personality Disorder ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Borderline Personality ◽  
Anterior Cingulate ◽  
Uncinate Fasciculus ◽  
White Matter Tracts ◽  
Structural Alterations

BackgroundA dysfunctional network of prefrontal and (para-)limbic brain region has been suggested to underlie emotional dysregulation in borderline personality disorder (BPD). Abnormal activity in this network may be due to structural alterations in white-matter tracts connecting prefrontal and (para-)limbic brain regions. To test this hypothesis, we investigated the structural integrity of major white-matter tracts connecting these regions in BPD.MethodUsing diffusion tensor imaging, we investigated fractional anisotropy (FA), axonal anisotropy (AD) and radial diffusivity (RD) in the uncinate fasciculus, the major white-matter tract connecting (para-)limbic and prefrontal brain regions, in 26 healthy controls (HC) and 26 BPD participants. To clarify the specificity of possible white-matter alterations among HC and BPD participants, FA, AD and RD were also investigated in the cingulum.ResultsWe found distinct structural alterations in the uncinate fasciculus but not in the cingulum of BPD participants. Compared to HC participants, BPD participants showed lower FA and higher RD in the uncinate fasciculus. By contrast, AD did not differ in the uncinate fasciculus of HC and BPD participants.ConclusionsOur finding of abnormal FA and RD in the uncinate fasciculus indicates distinct white-matter alterations in BPD, presumably due to stress-induced myelin degeneration in the aftermath of stressful life events. Although these alterations may account for abnormal activity in brain regions implicated in emotion dysregulation, such as the amygdala, anterior cingulate cortex and prefrontal cortex, it remains to be determined whether these alterations are specific for BPD.

Sign in / Sign up

Export Citation Format

Share Document