scholarly journals Age at onset of major depressive disorder in Han Chinese women: Relationship with clinical features and family history

2011 ◽  
Vol 135 (1-3) ◽  
pp. 89-94 ◽  
Author(s):  
Fuzhong Yang ◽  
Yihan Li ◽  
Dong Xie ◽  
Chunhong Shao ◽  
Jianer Ren ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Chinese Women ◽  
Age At Onset ◽  
Han Chinese ◽  
Major Depressive

scholarly journals Associations of Educational Attainment, Occupation, Social Class and Major Depressive Disorder among Han Chinese Women

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86674 ◽  
Author(s):  
Jianguo Shi ◽  
Yan Zhang ◽  
Feihu Liu ◽  
Yajuan Li ◽  
Junhui Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Social Class ◽  
Depressive Disorder ◽  
Educational Attainment ◽  
Chinese Women ◽  
Han Chinese ◽  
Major Depressive

scholarly journals Complement factor H and susceptibility to major depressive disorder in Han Chinese

2016 ◽  
Vol 208 (5) ◽  
pp. 446-452 ◽  
Author(s):  
Chen Zhang ◽  
Deng-Feng Zhang ◽  
Zhi-Guo Wu ◽  
Dai-Hui Peng ◽  
Jun Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Alternative Pathway ◽  
Age At Onset ◽  
Han Chinese ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Mrna Levels ◽  
Major Depressive

BackgroundAccumulating evidence suggests that altered immunity contributes to the development of major depressive disorder (MDD).AimsTo examine whether complement factor H (CFH), a regulator of activation of the alternative pathway of the complement cascade, confers susceptibility to MDD.MethodExpression analyses were tested in 53 unmedicated people with MDD and 55 healthy controls. A two-stage genetic association analysis was performed in 3323 Han Chinese with or without MDD. Potential associations between CFH single nucleotide polymorphisms and age at MDD onset were evaluated.ResultsCFH levels were significantly lower in the MDD group at both protein and mRNA levels (P = 0.009 and P = 0.014 respectively). A regulatory variant in the CFH gene, rs1061170, showed statistically significant genotypic and allelic differences between the MDD and control groups (genotypic P = 0.0005, allelic P = 0.0001). Kaplan–Meier survival analysis showed that age at onset of MDD was significantly associated with the C allele of rs1061170 (log rank statistic χ2 = 6.82, P = 0.009). The C-allele carriers had a younger age at onset of MDD (22.2 years, s.d. = 4.0) than those without the C allele (23.6 years, s.d. = 4.3).ConclusionsCFH is likely to play an important role in the development of MDD. rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD, although further study is needed.

scholarly journals The impact of educational status on the clinical features of major depressive disorder among Chinese women

2012 ◽  
Vol 136 (3) ◽  
pp. 988-992 ◽  
Author(s):  
Zhaoyu Gan ◽  
Yihan Li ◽  
Dong Xie ◽  
Chunhong Shao ◽  
Fuzhong Yang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Chinese Women ◽  
Educational Status ◽  
Major Depressive ◽  
The Impact

scholarly journals Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women

2017 ◽  
Vol 48 (5) ◽  
pp. 777-789 ◽  
Author(s):  
A. C. Edwards ◽  
A. R. Docherty ◽  
A. Moscati ◽  
T. B. Bigdeli ◽  
R. E. Peterson ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Characteristics ◽  
Chinese Women ◽  
Well Being ◽  
Han Chinese ◽  
Major Depressive ◽  
Genetic Liability ◽  
Polygenic Risk ◽  
Shared Genetic

BackgroundPrevious studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities.MethodThe relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximumN= 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined.ResultsEuropean-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case–control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity.ConclusionsThe shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and/or pathoplasticity.

scholarly journals The Genetic Architecture of Major Depressive Disorder in Han Chinese Women

2017 ◽  
Vol 74 (2) ◽  
pp. 162 ◽  
Author(s):  
Roseann E. Peterson ◽  
Na Cai ◽  
Tim B. Bigdeli ◽  
Yihan Li ◽  
Mark Reimers ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Genetic Architecture ◽  
Chinese Women ◽  
Han Chinese ◽  
Major Depressive

INVESTIGATION OF THE GENETIC OVERLAP BETWEEN MAJOR DEPRESSIVE DISORDER AND BODY MASS INDEX IN HAN CHINESE WOMEN

2019 ◽  
Vol 29 ◽  
pp. S976
Author(s):  
Roseann Peterson ◽  
Tim Bigdeli ◽  
Hanna van Loo ◽  
Bradley Webb ◽  
Jonathan Flint ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Body Mass ◽  
Chinese Women ◽  
Han Chinese ◽  
Major Depressive ◽  
Genetic Overlap

Clinical features of the patients with major depressive disorder co-occurring insomnia and hypersomnia symptoms: a report of NSSD study

2021 ◽  
Vol 81 ◽  
pp. 375-381
Author(s):  
Jie Zhao ◽  
Hongmei Liu ◽  
Zhiguo Wu ◽  
Yun Wang ◽  
Tongdan Cao ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Features ◽  
Major Depressive
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