Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood

2011 ◽  
Vol 128 (6) ◽  
pp. 1369-1371 ◽  
Author(s):  
Sytze de Roock ◽  
Sanne B.E.A. Hoeks ◽  
Linda Meurs ◽  
Anouk Steur ◽  
Maarten O. Hoekstra ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Cord Blood ◽  
Regulatory T Cell ◽  
Protein Kinase B ◽  
Critical Role ◽  
Programmed Death ◽  
Cell Induction ◽  
Programmed Death 1

Involvement of the Programmed Death-1/Programmed Death-1 Ligand Pathway in CD4+CD25+ Regulatory T-Cell Activity to Suppress Alloimmune Responses

2007 ◽  
Vol 83 (6) ◽  
pp. 774-782 ◽  
Author(s):  
Yusuke Kitazawa ◽  
Masayuki Fujino ◽  
Quanxing Wang ◽  
Hiromitsu Kimura ◽  
Miyuki Azuma ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Activity ◽  
Programmed Death ◽  
Programmed Death 1

Lycium barbarum Polysaccharides Enhance T-Cell Function by Inhibiting Programmed Death-Ligand 1 via Phosphoinositide-3-Kinase/Protein Kinase B Suppression in Bladder Cancer Cells

2020 ◽  
Vol 19 (3) ◽  
pp. 295-302
Author(s):  
Songzhe Piao ◽  
Chaoqian Chen ◽  
Xin Wang ◽  
Licai Mo ◽  
Tao Hong ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Cell Function ◽  
Protein Kinase B ◽  
Lycium Barbarum ◽  
Programmed Death Ligand 1 ◽  
T Cell Function ◽  
Programmed Death ◽  
Phosphoinositide 3 Kinase

Lycium barbarum is a boxthorn that produces the goji berries. L. barbarum polysaccharide is a water soluble bioactive component extracted from L. barbarum L. that has been shown to exert multiple pharmacological effects including antitumor effects. Herein, we have explored the mechanism underlying inhibition of tumor growth in J82 bearing bladder carcinoma by L. barbarum polysaccharides. The results of in vitro studies show that L. barbarum polysaccharide inhibited the expression of programmed death-ligand 1 protein, but not the gene transcription in bladder carcinoma cells. Also, L. barbarum polysaccharide decreased the level of phospho-protein kinase B/protein kinase B in cancer cells, and phosphoinositide- 3-kinase/protein kinase B pathway agonists reversed the inhibitory effect of L. barbarum polysaccharide on protein kinase B activation and programmed death-ligand 1 expression. Furthermore, when T cells and cancer cells were cultured together, treatments with either L. barbarum polysaccharide or antiprogrammed death-ligand 1 protein, enhanced T cell function including the expression of interferon-γ and interleukin-2 that were inhibited by phosphoinositide-3-kinase/protein kinase B pathway agonists. In conclusion, the results suggested that L. barbarum polysaccharide could inhibit programmed deathligand 1 expression via phosphoinositide-3-kinase/protein kinase B suppression of bladder cancer cells and further enhance the T-cell function in tumor microenvironment.

scholarly journals PD-L1 degradation pathway and immunotherapy for cancer

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Qian Gou ◽  
Chen Dong ◽  
Huihui Xu ◽  
Bibimaryam Khan ◽  
Jianhua Jin ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Immunotherapy ◽  
Immune Escape ◽  
Critical Role ◽  
Degradation Pathway ◽  
T Cell Proliferation ◽  
Programmed Death ◽  
Tumor Immunosuppression ◽  
Programmed Death 1 ◽  
L1 Protein

Abstract Programmed death ligand 1 (PD-L1, CD274) is an essential immune checkpoint protein that binds to programmed death 1 (PD-1) on T-lymphocytes. T cell plays a critical role in killing cancer cells while the cancer cell exhibits immune escape by the expression of PD-L1. The binding of PD-L1 to PD-1 inhibits T cell proliferation and activity, leading to tumor immunosuppression. Increasing evidence shows that PD-L1 protein undergoes degradation in proteasomes or lysosomes by multiple pathways, leading to enhanced immunotherapy for cancer. Although some specific drugs induce PD-L1 degradation and increase antitumor activity, the combination of these drugs with PD-L1/PD-1 blockade significantly enhances cancer immunotherapy. In this review, we have discussed the interaction of PD-L1 degradation with cancer immunotherapy.

scholarly journals Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation

2009 ◽  
Vol 183 (10) ◽  
pp. 6124-6134 ◽  
Author(s):  
Mandy Pierau ◽  
Swen Engelmann ◽  
Dirk Reinhold ◽  
Thabo Lapp ◽  
Burkhart Schraven ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Protein Kinase B ◽  
Cell Formation ◽  
T Cell Function ◽  
Th17 Differentiation
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