scholarly journals Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation

2009 ◽  
Vol 183 (10) ◽  
pp. 6124-6134 ◽  
Author(s):  
Mandy Pierau ◽  
Swen Engelmann ◽  
Dirk Reinhold ◽  
Thabo Lapp ◽  
Burkhart Schraven ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Protein Kinase B ◽  
Cell Formation ◽  
T Cell Function ◽  
Th17 Differentiation

Lycium barbarum Polysaccharides Enhance T-Cell Function by Inhibiting Programmed Death-Ligand 1 via Phosphoinositide-3-Kinase/Protein Kinase B Suppression in Bladder Cancer Cells

2020 ◽  
Vol 19 (3) ◽  
pp. 295-302
Author(s):  
Songzhe Piao ◽  
Chaoqian Chen ◽  
Xin Wang ◽  
Licai Mo ◽  
Tao Hong ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Cell Function ◽  
Protein Kinase B ◽  
Lycium Barbarum ◽  
Programmed Death Ligand 1 ◽  
T Cell Function ◽  
Programmed Death ◽  
Phosphoinositide 3 Kinase

Lycium barbarum is a boxthorn that produces the goji berries. L. barbarum polysaccharide is a water soluble bioactive component extracted from L. barbarum L. that has been shown to exert multiple pharmacological effects including antitumor effects. Herein, we have explored the mechanism underlying inhibition of tumor growth in J82 bearing bladder carcinoma by L. barbarum polysaccharides. The results of in vitro studies show that L. barbarum polysaccharide inhibited the expression of programmed death-ligand 1 protein, but not the gene transcription in bladder carcinoma cells. Also, L. barbarum polysaccharide decreased the level of phospho-protein kinase B/protein kinase B in cancer cells, and phosphoinositide- 3-kinase/protein kinase B pathway agonists reversed the inhibitory effect of L. barbarum polysaccharide on protein kinase B activation and programmed death-ligand 1 expression. Furthermore, when T cells and cancer cells were cultured together, treatments with either L. barbarum polysaccharide or antiprogrammed death-ligand 1 protein, enhanced T cell function including the expression of interferon-γ and interleukin-2 that were inhibited by phosphoinositide-3-kinase/protein kinase B pathway agonists. In conclusion, the results suggested that L. barbarum polysaccharide could inhibit programmed deathligand 1 expression via phosphoinositide-3-kinase/protein kinase B suppression of bladder cancer cells and further enhance the T-cell function in tumor microenvironment.

scholarly journals Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

2014 ◽  
Vol 15 (5) ◽  
pp. 465-472 ◽  
Author(s):  
Kok-Fai Kong ◽  
Guo Fu ◽  
Yaoyang Zhang ◽  
Tadashi Yokosuka ◽  
Javier Casas ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Kinase C ◽  
T Cell Function

scholarly journals Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

Science ◽  
2010 ◽  
Vol 328 (5976) ◽  
pp. 372-376 ◽  
Author(s):  
A. Zanin-Zhorov ◽  
Y. Ding ◽  
S. Kumari ◽  
M. Attur ◽  
K. L. Hippen ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
Negative Feedback ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Kinase C ◽  
T Cell Function

scholarly journals The protein kinase C inhibitor sotrastaurin allows regulatory T cell function

2014 ◽  
Vol 175 (2) ◽  
pp. 296-304 ◽  
Author(s):  
A. de Weerd ◽  
M. Kho ◽  
R. Kraaijeveld ◽  
J. Zuiderwijk ◽  
W. Weimar ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
T Cell ◽  
Protein Kinase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Kinase C ◽  
T Cell Function ◽  
Protein Kinase C Inhibitor
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