Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells

2007 ◽  
Vol 119 (2) ◽  
pp. 488-497 ◽  
Author(s):  
Marc A. Williams ◽  
Michael Porter ◽  
Maureen Horton ◽  
Jia Guo ◽  
Jessica Roman ◽  
...  
Keyword(s):  
T Cells ◽  
Particulate Matter ◽  
Dendritic Cell ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Cytokine Response ◽  
Ambient Particulate Matter ◽  
Dendritic Cell Activation

scholarly journals Salmonella typhimuriumCoordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+T cells

2006 ◽  
Vol 177 (6) ◽  
pp. 3983-3993 ◽  
Author(s):  
Robert C. Alaniz ◽  
Lisa A. Cummings ◽  
Molly A. Bergman ◽  
Sara L. Rassoulian-Barrett ◽  
Brad T. Cookson
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Dendritic Cell Activation

Mycobacterium tuberculosisPstS1 amplifies IFN-γ and induces IL-17/IL-22 responses by unrelated memory CD4+T cells via dendritic cell activation

2013 ◽  
Vol 43 (9) ◽  
pp. 2386-2397 ◽  
Author(s):  
Carla Palma ◽  
Giovanna Schiavoni ◽  
Laura Abalsamo ◽  
Fabrizio Mattei ◽  
Giovanni Piccaro ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Ifn Γ ◽  
Memory Cd4 T Cells

scholarly journals Human Lymphocyte Activation Gene-3 Molecules Expressed by Activated T Cells Deliver Costimulation Signal for Dendritic Cell Activation

2008 ◽  
Vol 180 (6) ◽  
pp. 3782-3788 ◽  
Author(s):  
Chiara Casati ◽  
Chiara Camisaschi ◽  
Luisa Novellino ◽  
Arabella Mazzocchi ◽  
Frédéric Triebel ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Human Lymphocyte ◽  
Cell Activation ◽  
Lymphocyte Activation ◽  
Dendritic Cell Activation ◽  
Activated T Cells ◽  
Lymphocyte Activation Gene

scholarly journals CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

Immunity ◽  
2006 ◽  
Vol 24 (5) ◽  
pp. 623-632 ◽  
Author(s):  
Rosa Maria Salazar-Gonzalez ◽  
Jan H. Niess ◽  
David J. Zammit ◽  
Rajesh Ravindran ◽  
Aparna Srinivasan ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dendritic Cell Activation

scholarly journals Anti–IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses

Blood ◽  
2011 ◽  
Vol 118 (19) ◽  
pp. 5340-5343 ◽  
Author(s):  
Brian C. Betts ◽  
Erin T. St Angelo ◽  
Michael Kennedy ◽  
James W. Young
Keyword(s):  
Cell Proliferation ◽  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Human Monocyte ◽  
T Cell Proliferation ◽  
Dendritic Cell Activation ◽  
Alloreactive T Cell

Abstract Significant comorbidites and lethality complicate GVHD and its treatment. Targeting the cytokine milieu may improve GVHD control; and IL6 is an attractive candidate, given its role in dendritic cell activation and T-cell differentiation. Tocilizumab is a humanized mAb to IL6-receptor-α (IL6R-α), which is Food and Drug Administration–approved for treatment of rheumatoid arthritis. Mouse transplant models have demonstrated that IL6 blockade also improves GVHD scores and survival. Definitive immunologic effects of IL6 inhibition have not emerged given inconsistent alterations in regulatory T cells (Tregs) and suppression of T-cell proliferation. Despite on-target suppression of IL6R-α signaling in human monocyte-derived dendritic cells (moDCs) and T cells, our data show no effect on moDC maturation/activation, alloreactive T-cell proliferation, Treg expansion, or allogeneic Th1/Th17 responses in vitro. These findings merit attention in any clinical trials of tocilizumab for GVHD prevention or treatment and provide a rationale for evaluating more specific inhibitors of downstream JAK2/STAT3 signaling as well.

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