Mycobacterium tuberculosisPstS1 amplifies IFN-γ and induces IL-17/IL-22 responses by unrelated memory CD4+T cells via dendritic cell activation

2013 ◽  
Vol 43 (9) ◽  
pp. 2386-2397 ◽  
Author(s):  
Carla Palma ◽  
Giovanna Schiavoni ◽  
Laura Abalsamo ◽  
Fabrizio Mattei ◽  
Giovanni Piccaro ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Ifn Γ ◽  
Memory Cd4 T Cells

scholarly journals Salmonella typhimuriumCoordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+T cells

2006 ◽  
Vol 177 (6) ◽  
pp. 3983-3993 ◽  
Author(s):  
Robert C. Alaniz ◽  
Lisa A. Cummings ◽  
Molly A. Bergman ◽  
Sara L. Rassoulian-Barrett ◽  
Brad T. Cookson
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Dendritic Cell Activation

scholarly journals Human Lymphocyte Activation Gene-3 Molecules Expressed by Activated T Cells Deliver Costimulation Signal for Dendritic Cell Activation

2008 ◽  
Vol 180 (6) ◽  
pp. 3782-3788 ◽  
Author(s):  
Chiara Casati ◽  
Chiara Camisaschi ◽  
Luisa Novellino ◽  
Arabella Mazzocchi ◽  
Frédéric Triebel ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Human Lymphocyte ◽  
Cell Activation ◽  
Lymphocyte Activation ◽  
Dendritic Cell Activation ◽  
Activated T Cells ◽  
Lymphocyte Activation Gene

scholarly journals Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

2009 ◽  
Vol 39 (5) ◽  
pp. 1301-1312 ◽  
Author(s):  
Giorgio Napolitani ◽  
Eva V. Acosta-Rodriguez ◽  
Antonio Lanzavecchia ◽  
Federica Sallusto
Keyword(s):  
T Cells ◽  
Prostaglandin E2 ◽  
Cd4 T Cells ◽  
Ifn Γ ◽  
Memory Cd4 T Cells

scholarly journals HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

2003 ◽  
Vol 198 (12) ◽  
pp. 1909-1922 ◽  
Author(s):  
Souheil-Antoine Younes ◽  
Bader Yassine-Diab ◽  
Alain R. Dumont ◽  
Mohamed-Rachid Boulassel ◽  
Zvi Grossman ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cd4 T Cell ◽  
Memory Cells ◽  
Cell Responses ◽  
Specific Memory ◽  
Ifn Γ ◽  
Memory Cd4 T Cells

CD4+ T cell responses are associated with disease control in chronic viral infections. We analyzed human immunodeficiency virus (HIV)-specific responses in ten aviremic and eight viremic patients treated during primary HIV-1 infection and for up to 6 yr thereafter. Using a highly sensitive 5-(and-6)-carboxyfluorescein diacetate-succinimidyl ester–based proliferation assay, we observed that proliferative Gag and Nef peptide-specific CD4+ T cell responses were 30-fold higher in the aviremic patients. Two subsets of HIV-specific memory CD4+ T cells were identified in aviremic patients, CD45RA− CCR7+ central memory cells (Tcm) producing exclusively interleukin (IL)-2, and CD45RA− CCR7− effector memory cells (Tem) that produced both IL-2 and interferon (IFN)-γ. In contrast, in viremic, therapy-failing patients, we found significant frequencies of Tem that unexpectedly produced exclusively IFN-γ. Longitudinal analysis of HIV epitope–specific CD4+ T cells revealed that only cells that had the capacity to produce IL-2 persisted as long-term memory cells. In viremic patients the presence of IFN-γ–producing cells was restricted to periods of elevated viremia. These findings suggest that long-term CD4+ T cell memory depends on IL-2–producing CD4+ T cells and that IFN-γ only–producing cells are short lived. Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-γ only–producing cells that lack self-renewal capacity.

CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency

Blood ◽  
2007 ◽  
Vol 110 (13) ◽  
pp. 4161-4164 ◽  
Author(s):  
Suha Saleh ◽  
Ajantha Solomon ◽  
Fiona Wightman ◽  
Miranda Xhilaga ◽  
Paul U. Cameron ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Lymphocyte Migration ◽  
Major Barrier ◽  
Memory Cd4 T Cells ◽  
Novel Model ◽  
Hiv 1

Latent HIV-1 infection of resting memory CD4+ T cells represents the major barrier to HIV-1 eradication. To determine whether the CCR7 ligands involved in lymphocyte migration can alter HIV-1 infection of resting CD4+ T cells, we infected purified resting CD4+ T cells after incubation with the chemokines CCL19 and CCL21. Incubation with CCL19 or CCL21 did not alter markers of T-cell activation or proliferation. However, after HIV-1 infection of CCL19- or CCL21-treated CD4+ T-cells, we observed low-level HIV-1 production but high concentrations of integrated HIV-1 DNA, approaching that seen in mitogen-stimulated T-cell blasts. Restimulation of CCL19-treated infected CD4+ T cells resulted in virus production consistent with establishment of postintegration latency. CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4+ T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro.

scholarly journals CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

Immunity ◽  
2006 ◽  
Vol 24 (5) ◽  
pp. 623-632 ◽  
Author(s):  
Rosa Maria Salazar-Gonzalez ◽  
Jan H. Niess ◽  
David J. Zammit ◽  
Rajesh Ravindran ◽  
Aparna Srinivasan ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dendritic Cell Activation
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