Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy

2004 ◽  
Vol 114 (2) ◽  
pp. 387-391 ◽  
Author(s):  
Lynette P.C. Shek ◽  
Lars Soderstrom ◽  
Staffan Ahlstedt ◽  
Kirsten Beyer ◽  
Hugh A. Sampson
Keyword(s):  
Specific Ige ◽  
Cow’S Milk ◽  
Egg Allergy ◽  
Cow's Milk ◽  
Hen’S Egg ◽  
Food Specific Ige ◽  
Over Time ◽  
Development Of Tolerance

Atopy patch test in children with cow's milk and hen's egg allergy: Do clinical symptoms matter?

2020 ◽  
Vol 48 (4) ◽  
pp. 323-331
Author(s):  
S. Sirin Kose ◽  
S. Asilsoy ◽  
D. Tezcan ◽  
G. Atakul ◽  
S. Al ◽  
...  
Keyword(s):  
Patch Test ◽  
Clinical Symptoms ◽  
Cow’S Milk ◽  
Atopy Patch Test ◽  
Egg Allergy ◽  
Cow's Milk ◽  
Hen’S Egg

scholarly journals Efficacy and safety of allergen immunotherapy for IgE-mediated food allergy: systematic review and meta-analysis

2021 ◽  
Author(s):  
Debra de Silva ◽  
Pablo Rodriguez del Rio ◽  
Nicolette w Jong ◽  
Ekaterina Khaleva ◽  
C. Singh ◽  
...  
Keyword(s):  
Food Allergy ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Oral Immunotherapy ◽  
Cow’S Milk ◽  
Egg Allergy ◽  
Efficacy And Safety ◽  
Cow's Milk ◽  
Hen’S Egg ◽  
Ige Mediated

Background There is substantial interest in allergen-specific immunotherapy in food allergy. We systematically reviewed its efficacy and safety. Methods We searched six bibliographic databases from 1946 to 30 April 2021 for randomised controlled trials about immunotherapy alone or with biologicals in IgE-mediated food allergy confirmed by oral food challenge. We pooled the data using random-effects meta-analysis. Results We included 36 trials with 2,126 participants, mainly children. Oral immunotherapy increased tolerance whilst on therapy for peanut (RR 9.9, 95% CI 4.5. to 21.4, high certainty); cow’s milk (RR 5.7, 1.9 to 16.7, moderate certainty) and hen’s egg allergy (RR 8.9, 4.4 to 18, moderate certainty). The number needed to treat to increase tolerance to a single dose of 300mg or 1000mg peanut protein was 2. In peanut allergy, oral immunotherapy did not increase adverse reactions (RR 1.1, 1.0 to 1.2, low certainty) or severe reactions (RR 1,6, 0.7 to 3.5, low certainty). It may increase adverse reactions in cow’s milk (RR 3.9, 2.1 to 7.5, low certainty) and hen’s egg allergy (RR 7.0, 2.4 to 19.8, moderate certainty), but reactions tended to be mild and gastrointestinal. Epicutaneous immunotherapy increased tolerance whilst on therapy for peanut (RR 2.6, 1.8 to 3.8, moderate certainty). Results were unclear for other allergies and administration routes. Conclusions Oral immunotherapy improves tolerance whilst on therapy and is probably safe in peanut, cow’s milk and hen’s egg allergy. However, our review found little about whether this improves quality of life, is sustained or cost-effective.

Diagnostic value of food specific IgE antibodies in children with immediate digestive symptoms to cow's milk

2004 ◽  
Vol 145 (5) ◽  
pp. 715-716 ◽  
Author(s):  
M. Castro ◽  
A. Diamanti ◽  
S. Mancini ◽  
S. Bella ◽  
B. Papadatou ◽  
...  
Keyword(s):  
Specific Ige ◽  
Diagnostic Value ◽  
Cow’S Milk ◽  
Ige Antibodies ◽  
Cow's Milk ◽  
Specific Ige Antibodies ◽  
Food Specific Ige

scholarly journals Algorithm of conducting oral provocation tests with milk in 1–3-year-old children: analysis of existing standards and own experience

2021 ◽  
Keyword(s):  
Milk Protein ◽  
Specific Ige ◽  
Physical Development ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Oral Provocation ◽  
Provocation Tests ◽  
Cow’S Milk Protein

Introduction. Food allergy is an urgent problem in modern pediatrics. Cow’s milk is the main food allergen in young children. By the age of one year, from 0.5 % to 3 % of children suffer from cow’s milk protein allergy. Aim. To analyze the existing standards of conducting oral provocation tests with milk in young children and suggest own algorithm of diagnostics. Materials and methods. Algorithm of diagnosing cow’s milk allergy was probated in 107 children aged from one to three years in Communal Municipal Children’s Clinical Hospital. To diagnose cow’s milk allergy, compilation of allergological anamnesis, examination, assessment of physical development, and determination of specific IgE to cow’s milk are performed. Then, different oral provocation tests are conducted based on the obtained results: at the allergist’s office on an outpatient basis, in a specialized inpatient department, in an intensive care unit. Results. Among 107 children, who were subjected to oral provocation test with milk, cow’s milk protein allergy was diagnosed in 67 (62.62 %). In children, who were diagnosed cow’s milk protein allergy (n = 67), skin (41.79 %) and gastrointestinal (28.36 %) symptoms prevailed. In the group of children with predictable low risk of allergy, diameter of a papule equaled 3.86 ± 0.62 mm2, the level of specific IgE to milk in blood serum was 0.58 [0.37–0.68], and in the group with medium risk – 5.51 ± 1.38 mm2 and 3.62 [0.86–9.66] kU/L, respectively. All 40 children, in whom cow’s milk protein allergy was not confirmed, constituted the group with predictable low risk of reaction development. Diameter of a papule during prick-test equaled 3.13 ± 0.24 mm2, the level of specific IgE to milk in blood serum was 0.36 [0.35–0.67] kU/L. In this group of children, complaints of gastrointestinal symptoms (82.5 %) prevailed. Conclusions. A complex diagnostic approach, in particular, study of anamnesis, examination, assessment of physical development, record of food diary, determination of specific IgE to milk, oral provocation tests enable to optimize diagnostics of food allergy and choose further therapeutic tactics. Algorithm of diagnosing cow’s milk protein allergy in 1–3-year-old children has been elaborated, which can be recommended for common application in clinical practice.

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