scholarly journals Functional SYNTAX Score for Risk Assessment in Multivessel Coronary Artery Disease

2011 ◽  
Vol 58 (12) ◽  
pp. 1211-1218 ◽  
Author(s):  
Chang-Wook Nam ◽  
Fabio Mangiacapra ◽  
Robert Entjes ◽  
In-Sung Chung ◽  
Jan-Willem Sels ◽  
...  
2014 ◽  
Vol 78 (8) ◽  
pp. 1942-1949 ◽  
Author(s):  
Carlos M. Campos ◽  
David van Klaveren ◽  
Javaid Iqbal ◽  
Yoshinobu Onuma ◽  
Yao-Jun Zhang ◽  
...  

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
P Guedeney ◽  
O Barthelemy ◽  
M Zeitouni ◽  
M Hauguel-Moreau ◽  
G Hage ◽  
...  

Abstract Background The majority of patients presenting with myocardial infarction (MI) and cardiogenic shock (CS) have multivessel coronary artery disease. The prognosis impact of the SYNTAX score (SS) in this setting remains unknown. Purpose To evaluate the prognosis value of the SS in this high-risk population undergoing percutaneous coronary intervention (PCI) Methods The CULPRIT-SHOCK trial was an international, open-label trial, where patients presenting with MI and multivessel disease complicated by CS were randomized to a culprit-lesion-only or an immediate multivessel PCI strategy. Pre-PCI SS was assessed by a central core laboratory and patients were categorized as low SS (SS ≤22), intermediate SS (22<SS≤32) and high SS (SS>32). Adjudicated endpoints of interest were the risks of all-cause death or renal replacement therapy at 30 days and all-cause death at 1 year. Associations between SYNTAX score and outcomes were assessed using multivariate logistic regression. Results SS was available in 632 patients, of whom 265 (41.9%), 211 (33.4%) and 156 (24.7%) presented with low, intermediate and high SS, respectively. Patients with higher SS were older, with more frequent peripheral artery disease, less current smoking, lower creatinine clearance, and higher use of catecholamine. A stepwise increase in the incidence of adverse events transitioning from low to intermediate and high SS was observed with the 30-day risk of death or renal replacement therapy as well as the 1-year risk of all-cause death (p for trend <0.001, for all). After multiple adjustment, intermediate and high SS remained strongly associated with 30-day risk of death and renal replacement therapy and 1-year risk of all-cause death (Figure). There was no significant interaction between SYNTAX score and the coronary revascularization strategy for all endpoints. Conclusion In patients presenting with acute MI, multivessel disease and CS, the SYNTAX score was strongly associated to 30-day and 1-year mortality</ss≤<ss≤32)> Acknowledgement/Funding The CULPRIT-SHOCK trial was Supported by a grant agreement (602202) from the European Union Seventh Framework Program and by the German Heart Research


2019 ◽  
Vol 40 (4) ◽  
Author(s):  
Jaya Suganti ◽  
Anggia Chairuddin Lubis ◽  
Abdullah Afif Siregar ◽  
Andika Sitepu ◽  
Cut Aryfa Andra ◽  
...  

Precordial ST Segment Depression on Admission Electrocardiogram as a Simple Noninvasive Tool for Predicting Coronary Artery Disease Complexity in Patients with Inferior Myocardial Infarction   Jaya Suganti, Anggia Chairuddin Lubis, Abdullah Afif Siregar, Andika Sitepu, Cut Aryfa Andra, Ali Nafiah Nasution, Harris Hasan   Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia     Background: Whether a precordial ST segment depression (PSTD) is merely a benign electrical phenomena or a sign of multivessel coronary artery disease (MVCAD) in inferior myocardial infarction (MI) remains unclear. The objective of this study is to analyze the complexity of coronary artery disease (CAD) in inferior MI patients with PSTD and to investigate whether PSTD can be used as a predictor of MVCAD in inferior MI. Methods: Patients with inferior MI were divided into two groups based on the presence of PSTD on admission ECG and were compared based on the patient’s coronary artery complexities. Results: A total of 215 patients with inferior MI were found in this study period, with 102 patients meet the inclusion and exclusion criteria. Patients with PSTD had a higher incidence of MVCAD and SYNTAX score. Further analyzes showed PSTD on admission ECG was an independent predictor of MVCAD in inferior MI [45 (66%) vs 23 (34%); OR 4.097; 95% CI 1.638-10.247; p=0.003). Conclusion: In daily clinical practice, PSTD on admission ECG may serve as a simple noninvasive tool for predicting MVCAD or a more complex CAD in inferior MI.   Keywords: Precordial ST Segment depression, inferior myocardial infarction, SYNTAX score  


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