2.67 Immune-Mediated Comorbidities in Children With Obsessive-Compulsive Disorder and Their First-Degree Relatives

2017 ◽  
Vol 56 (10) ◽  
pp. S201
Author(s):  
Clara Westwell-Roper ◽  
Fern Jaspers-Fayer ◽  
S. Evelyn Stewart
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives ◽  
Immune Mediated

scholarly journals Familial Clustering of Immune-Mediated Diseases in Children with Abrupt-Onset Obsessive Compulsive Disorder

2020 ◽  
Vol 30 (5) ◽  
pp. 345-346
Author(s):  
Avis Chan ◽  
Tiffany Phu ◽  
Bahare Farhadian ◽  
Theresa Willett ◽  
Margo Thienemann ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Abrupt Onset ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Immune Mediated ◽  
Familial Clustering

scholarly journals The effects of acute serotonin challenge on executive planning in patients with obsessive–compulsive disorder (OCD), their first-degree relatives, and healthy controls

2020 ◽  
Vol 237 (10) ◽  
pp. 3117-3123
Author(s):  
Christine Lochner ◽  
Samuel R. Chamberlain ◽  
Martin Kidd ◽  
Lian Taljaard ◽  
Naomi A. Fineberg ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives

Investigating Tourette Syndrome as a Neurologic Sequela of Rheumatic Fever

CNS Spectrums ◽  
1999 ◽  
Vol 4 (2) ◽  
pp. 62-67 ◽  
Author(s):  
Roger Kurlan
Keyword(s):  
Rheumatic Fever ◽  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Research Evidence ◽  
Streptococcal Infection ◽  
Molecular Mimicry ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Neurologic Sequela ◽  
Immune Mediated

AbstractSydenham's chorea is currently recognized as the only neurologic sequela of rheumatic fever. Recent evidence suggests that there may be a spectrum of neurobehavioral disturbances, particularly including tics and obsessive-compulsive disorder, that develops following streptococcal infection by the process of molecular mimicry, whereby antibodies directed against bacterial antigens cross-react with brain targets. This proposed postinfectious, immune-mediated condition has been termed “pediatric autoimmune neuropsychiatric disorders after streptococcal infection” (PANDAS). This article reviews research evidence in favor and also against the PANDAS concept and discusses the implications of the hypothesis.

scholarly journals Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder

2007 ◽  
Vol 164 (2) ◽  
pp. 335-338 ◽  
Author(s):  
Samuel R. Chamberlain ◽  
Naomi A. Fineberg ◽  
Lara A. Menzies ◽  
Andrew D. Blackwell ◽  
Edward T. Bullmore ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cognitive Flexibility ◽  
Motor Inhibition ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives

Impaired planning in patients with obsessive-compulsive disorder and unaffected first-degree relatives: Evidence for a cognitive endophenotype

2018 ◽  
Vol 57 ◽  
pp. 24-30 ◽  
Author(s):  
Katharina Bey ◽  
Christian Kaufmann ◽  
Leonhard Lennertz ◽  
Anja Riesel ◽  
Julia Klawohn ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder

2019 ◽  
Vol 50 (9) ◽  
pp. 1490-1500 ◽  
Author(s):  
Chenjie Dong ◽  
Qiong Yang ◽  
Jingjing Liang ◽  
Carol A. Seger ◽  
Hongying Han ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Effective Connectivity ◽  
Learning System ◽  
Causality Analysis ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives ◽  
Left Caudate ◽  
Directed Learning

AbstractBackgroundCompulsive behaviors in obsessive-compulsive disorder (OCD) have been related to impairment within the associative cortical-striatal system connecting the caudate and prefrontal cortex that underlies consciously-controlled goal-directed learning and behavior. However, little is known whether this impairment may serve as a biomarker for vulnerability to OCD.MethodsUsing resting-state functional magnetic resonance imaging (fMRI), we employed Granger causality analysis (GCA) to measure effective connectivity (EC) in previously validated striatal sub-regions, including the caudate, putamen, and the nucleus accumbens, in 35 OCD patients, 35 unaffected first-degree relatives and 35 matched healthy controls.ResultsBoth OCD patients and their first-degree relatives showed greater EC than controls between the left caudate and the orbital frontal cortex (OFC). Both OCD patients and their first-degree relatives showed lower EC than controls between the left caudate and lateral prefrontal cortex. These results are consistent with findings from task-related fMRI studies which found impairment in the goal-directed system in OCD patients.ConclusionsThe same changes in EC were present in both OCD patients and their unaffected first-degree relatives suggest that impairment in the goal-directed learning system may be a biomarker for OCD.

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