1.49 Trofinetide, A Novel IGF-1 Related Treatment for Neurodevelopmental Disorders, Demonstrates Efficacy for Children and Adolescents With Rett Syndrome

2017 ◽  
Vol 56 (10) ◽  
pp. S168-S169 ◽  
Author(s):  
Alan Percy ◽  
Daniel G. Glaze ◽  
Jeffrey L. Neul ◽  
Walter E. Kaufmann ◽  
Elizabeth Berry-Kravis ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Rett Syndrome ◽  
Neurodevelopmental Disorders

scholarly journals Neurodevelopmental Trajectories and Clinical Profiles in a Sample of Children and Adolescents With Early- and Very-Early-Onset Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Pontillo ◽  
Roberto Averna ◽  
Maria Cristina Tata ◽  
Fabrizia Chieppa ◽  
Maria Laura Pucciarini ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Neurodevelopmental Disorders ◽  
Early Onset ◽  
Social Role ◽  
Treatment Plan ◽  
Neurodevelopmental Disorder ◽  
Communication Disorders ◽  
Autism Spectrum ◽  
Early Onset Schizophrenia ◽  
Assessment And Treatment

Schizophrenia before the age of 18 years is usually divided into two categories. Early-onset schizophrenia (EOS) presents between the ages of 13 and 17 years, whereas very-early-onset schizophrenia (VEOS) presents at or before the age of 12 years. Previous studies have found that neurodevelopmental difficulties in social, motor, and linguistic domains are commonly observed in VEOS/EOS patients. Recent research has also shown a high prevalence of neurodevelopmental disorders (e.g., intellectual disability, communication disorders, autism spectrum disorder, neurodevelopmental motor disorders) in VEOS/EOS patients, indicating genetic overlap between these conditions. These findings lend support to the neurodevelopmental continuum model, which holds that childhood neurodevelopmental disorders and difficulties and psychiatric disorders (e.g., schizophrenia) fall on an etiological and neurodevelopmental continuum, and should not be considered discrete entities. Based on this literature, in this study we focused on the overlap between neurodevelopmental disorders and schizophrenia investigating, in a large sample (N = 230) of VEOS/EOS children and adolescents, the clinical differences, at the onset of psychosis, between VEOS/EOS with neurodevelopmental disorder or neurodevelopmental difficulties and VEOS/EOS with no diagnosed neurodevelopmental disorder or neurodevelopmental difficulties. The findings showed that, in children and adolescents with a neurodevelopmental disorder or neurodevelopmental difficulties, psychosis onset occurred at an earlier age, was associated with more severe functional impairment (e.g., global, social, role), and was characterized by positive symptoms (e.g., grandiose ideas, perceptual abnormalities, disorganized communication) and disorganized symptoms (e.g., odd behavior or appearance, bizarre thinking). Instead, in children and adolescents without a neurodevelopmental disorder or neurodevelopmental difficulties, psychosis onset was mainly characterized by negative symptomatology (e.g., social anhedonia, avolition, expression of emotion, experience of emotions and self, ideational richness). Given these differences, the presence of a neurodevelopmental disorder or neurodevelopmental difficulties should be carefully investigated and integrated early into the assessment and treatment plan for VEOS/EOS patients.

Assistive Technology-Based Programs and Cognitive-Behavioral Interventions for Helping Adaptive Responding of Children and Adolescents With Rett Syndrome

2021 ◽  
pp. 167-188
Author(s):  
Fabrizio Stasolla ◽  
Alessandro O. Caffò ◽  
Viviana Perilli
Keyword(s):  
Assistive Technology ◽  
Children And Adolescents ◽  
Rett Syndrome ◽  
Challenging Behavior ◽  
Behavioral Interventions ◽  
Cognitive Behavioral ◽  
Adaptive Skills ◽  
Future Research ◽  
Cognitive Behavioral Interventions ◽  
Adaptive Responding

This chapter provides the reader with a concise overview of the newest empirical evidences available on the use of assistive technology and cognitive behavioral interventions to promote adaptive skills and decrease challenging behaviors of children and adolescents with Rett syndrome and severe to profound developmental disabilities. Four main categories of studies were identified, namely (1) communication skills, (2) adaptive skills, (3) challenging behavior, and (4) on-task behavior. Twenty-six contributions were reviewed, and 936 participants were involved. Results were largely positive, although rare failures occurred. Educational, clinical, rehabilitative, and psychological implications of the findings were critically discussed. Some useful suggestions for future research and practice were emphasized.

Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review

Autism ◽  
2019 ◽  
Vol 23 (7) ◽  
pp. 1614-1629 ◽  
Author(s):  
Fumi Masuda ◽  
Shinichiro Nakajima ◽  
Takahiro Miyazaki ◽  
Ryosuke Tarumi ◽  
Kamiyu Ogyu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Children And Adolescents ◽  
Neurodevelopmental Disorders ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Dorsolateral Prefrontal

Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders.

scholarly journals Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community: A Descriptive Review

2019 ◽  
Vol 20 (17) ◽  
pp. 4160 ◽  
Author(s):  
Elisa Borghi ◽  
Aglaia Vignoli
Keyword(s):  
Microbial Community ◽  
Gut Microbiota ◽  
Rett Syndrome ◽  
Neurodevelopmental Disorders ◽  
Short Chain Fatty Acids ◽  
Dynamic Effects ◽  
Common Pathway ◽  
Gut Microbial Community ◽  
Host Metabolism

In this narrative review, we summarize recent pieces of evidence of the role of microbiota alterations in Rett syndrome (RTT). Neurological problems are prominent features of the syndrome, but the pathogenic mechanisms modulating its severity are still poorly understood. Gut microbiota was recently demonstrated to be altered both in animal models and humans with different neurodevelopmental disorders and/or epilepsy. By investigating gut microbiota in RTT cohorts, a less rich microbial community was identified which was associated with alterations of fecal microbial short-chain fatty acids. These changes were positively correlated with severe clinical outcomes. Indeed, microbial metabolites can play a crucial role both locally and systemically, having dynamic effects on host metabolism and gene expression in many organs. Similar alterations were found in patients with autism and down syndrome as well, suggesting a potential common pathway of gut microbiota involvement in neurodevelopmental disorders.

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