scholarly journals Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder

2016 ◽  
Vol 55 (4) ◽  
pp. 319-327 ◽  
Author(s):  
Rémi Patriat ◽  
Rasmus M. Birn ◽  
Taylor J. Keding ◽  
Ryan J. Herringa
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Stress Disorder ◽  
Default Mode

scholarly journals Altered default mode network configuration in posttraumatic stress disorder after earthquake

Medicine ◽  
2017 ◽  
Vol 96 (37) ◽  
pp. e7826 ◽  
Author(s):  
Xiao-Dong Zhang ◽  
Yan Yin ◽  
Xiao-Lei Hu ◽  
Lian Duan ◽  
Rongfeng Qi ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Stress Disorder ◽  
Network Configuration ◽  
Default Mode

581. The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach

2017 ◽  
Vol 81 (10) ◽  
pp. S235 ◽  
Author(s):  
Teddy Akiki ◽  
Christopher Averill ◽  
Kristen Wrocklage ◽  
J. Cobb Scott ◽  
Aaron Alexander-Bloch ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Stress Disorder ◽  
Data Driven ◽  
Multimodal Approach ◽  
Default Mode

scholarly journals Posttraumatic stress disorder is associated with alpha dysrhythmia across the visual cortex and the default mode network

2019 ◽  
Author(s):  
Kevin J. Clancy ◽  
Jeremy A. Andrzejewski ◽  
Mingzhou Ding ◽  
Norman B. Schmidt ◽  
Wen Li
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Visual Cortex ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Resting State ◽  
Stress Disorder ◽  
Posterior Cingulate Cortex ◽  
Cortical Inhibition ◽  
Alpha Power ◽  
Default Mode

ABSTRACTBackgroundAnomalies in default mode network (DMN) activity and alpha (8-12 Hz) oscillations have been independently observed in posttraumatic stress disorder (PTSD). Recent spatiotemporal analyses suggest that alpha oscillations support DMN functioning via inter-regional synchronization and sensory cortical inhibition. Therefore, we examined a unifying pathology of alpha deficits in the visual-cortex-DMN system in PTSD.MethodsPatients with PTSD (N = 25) and two control groups—patients with Generalized Anxiety Disorder (N = 24) and healthy controls (N = 20)—underwent a standard eyes-open resting state (S-RS) and a modified resting state (M-RS) of passively viewing salient images (known to deactivate the DMN). High-density electroencephalogram (hdEEG) were recorded, from which intracortical alpha activity (power and connectivity/Granger causality) was extracted using the exact low-resolution electromagnetic tomography (eLORETA).ResultsPatients with PTSD (vs. controls) demonstrated attenuated alpha power in the visual cortex and key hubs of the DMN (posterior cingulate cortex/PCC and medial prefrontal cortex/mPFC) at both states, the severity of which further correlated with hypervigilance symptoms. With increased visual input (at M-RS vs. S-RS), patients with PTSD further demonstrated reduced alpha-frequency directed connectivity within the DMN (PCC→mPFC) and, importantly, from the visual cortex (VC) to both DMN hubs (VC→PCC and VC→mPFC), linking alpha deficits in the two systems.ConclusionsThese interrelated alpha deficits align with DMN hypoactivity/hypoconnectivity, sensory disinhibition, and hypervigilance in PTSD, representing a unifying neural underpinning of these anomalies. The identification of visual-cortex-DMN alpha dysrhythmia in PTSD further presents a novel therapeutic target, promoting network-based intervention of neural oscillations.

scholarly journals Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach

NeuroImage ◽  
2018 ◽  
Vol 176 ◽  
pp. 489-498 ◽  
Author(s):  
Teddy J. Akiki ◽  
Christopher L. Averill ◽  
Kristen M. Wrocklage ◽  
J. Cobb Scott ◽  
Lynnette A. Averill ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Stress Disorder ◽  
Default Mode

scholarly journals Default Mode Network Subsystems Are Differentially Disrupted in Posttraumatic Stress Disorder

2017 ◽  
Vol 2 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Danielle R. Miller ◽  
Scott M. Hayes ◽  
Jasmeet P. Hayes ◽  
Jeffrey M. Spielberg ◽  
Ginette Lafleche ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Stress Disorder ◽  
Default Mode
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