scholarly journals ALTERED DEFAULT MODE NETWORK (DMN) RESTING STATE FUNCTIONAL CONNECTIVITY FOLLOWING A MINDFULNESS-BASED EXPOSURE THERAPY FOR POSTTRAUMATIC STRESS DISORDER (PTSD) IN COMBAT VETERANS OF AFGHANISTAN AND IRAQ

2016 ◽  
Vol 33 (4) ◽  
pp. 289-299 ◽  
Author(s):  
Anthony P. King ◽  
Stefanie R. Block ◽  
Rebecca K. Sripada ◽  
Sheila Rauch ◽  
Nicholas Giardino ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Functional Connectivity ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Resting State ◽  
Combat Veterans ◽  
Stress Disorder ◽  
Exposure Therapy ◽  
Resting State Functional Connectivity ◽  
Default Mode

scholarly journals An investigation of resting state functional connectivity of the anterior and posterior Hippocampal subregions in posttraumatic stress disorder and its relationship with symptoms

2021 ◽  
Author(s):  
Bailee L. Malivoire
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Functional Connectivity ◽  
Posttraumatic Stress ◽  
Resting State ◽  
Stress Disorder ◽  
Brain Regions ◽  
Imaging Biomarkers ◽  
Resting State Functional Connectivity ◽  
Hippocampal Activity ◽  
The Right

Posttraumatic stress disorder (PTSD) is associated with abnormal hippocampal activity; however, the functional connectivity (FC) of the hippocampus with other brain regions and its relations with symptoms warrants further attention. I investigated FC of the hippocampus at a subregional level in PTSD during a resting state compared to trauma exposed controls (TECs). Based on imaging literature in PTSD, I targeted the FCs of the hippocampal head and tail subregions with the amygdala, medial prefrontal cortex (mPFC), and the posterior cingulate (PCC). The PTSD group had significantly greater FC compared to the TEC group between the left hippocampal head and the right amygdala, and for the left hippocampal tail with bilateral PCC. Resting state FC predicted symptom severity at time of scan and 4-months post-scan. These results highlight abnormal illness-related FC with both the hippocampal head and tail and provide support for future investigations of imaging biomarkers predictive of disease progression.

scholarly journals Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder

2021 ◽  
Vol 15 ◽  
pp. 100389
Author(s):  
Liat Helpman ◽  
Xi Zhu ◽  
Sigal Zilcha-Mano ◽  
Benjamin Suarez-Jimenez ◽  
Amit Lazarov ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Functional Connectivity ◽  
Posttraumatic Stress ◽  
Resting State ◽  
Stress Disorder ◽  
Resting State Functional Connectivity

scholarly journals Posttraumatic stress disorder is associated with alpha dysrhythmia across the visual cortex and the default mode network

2019 ◽  
Author(s):  
Kevin J. Clancy ◽  
Jeremy A. Andrzejewski ◽  
Mingzhou Ding ◽  
Norman B. Schmidt ◽  
Wen Li
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Visual Cortex ◽  
Posttraumatic Stress ◽  
Default Mode Network ◽  
Resting State ◽  
Stress Disorder ◽  
Posterior Cingulate Cortex ◽  
Cortical Inhibition ◽  
Alpha Power ◽  
Default Mode

ABSTRACTBackgroundAnomalies in default mode network (DMN) activity and alpha (8-12 Hz) oscillations have been independently observed in posttraumatic stress disorder (PTSD). Recent spatiotemporal analyses suggest that alpha oscillations support DMN functioning via inter-regional synchronization and sensory cortical inhibition. Therefore, we examined a unifying pathology of alpha deficits in the visual-cortex-DMN system in PTSD.MethodsPatients with PTSD (N = 25) and two control groups—patients with Generalized Anxiety Disorder (N = 24) and healthy controls (N = 20)—underwent a standard eyes-open resting state (S-RS) and a modified resting state (M-RS) of passively viewing salient images (known to deactivate the DMN). High-density electroencephalogram (hdEEG) were recorded, from which intracortical alpha activity (power and connectivity/Granger causality) was extracted using the exact low-resolution electromagnetic tomography (eLORETA).ResultsPatients with PTSD (vs. controls) demonstrated attenuated alpha power in the visual cortex and key hubs of the DMN (posterior cingulate cortex/PCC and medial prefrontal cortex/mPFC) at both states, the severity of which further correlated with hypervigilance symptoms. With increased visual input (at M-RS vs. S-RS), patients with PTSD further demonstrated reduced alpha-frequency directed connectivity within the DMN (PCC→mPFC) and, importantly, from the visual cortex (VC) to both DMN hubs (VC→PCC and VC→mPFC), linking alpha deficits in the two systems.ConclusionsThese interrelated alpha deficits align with DMN hypoactivity/hypoconnectivity, sensory disinhibition, and hypervigilance in PTSD, representing a unifying neural underpinning of these anomalies. The identification of visual-cortex-DMN alpha dysrhythmia in PTSD further presents a novel therapeutic target, promoting network-based intervention of neural oscillations.

scholarly journals Altered functional connectivity in posttraumatic stress disorder with versus without comorbid major depressive disorder: a resting state fMRI study

F1000Research ◽  
2014 ◽  
Vol 2 ◽  
pp. 289 ◽  
Author(s):  
Mitzy Kennis ◽  
Arthur R. Rademaker ◽  
Sanne J.H. van Rooij ◽  
René S. Kahn ◽  
Elbert Geuze
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Resting State ◽  
Stress Disorder ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
Major Depressive

Posttraumatic stress disorder (PTSD) is an anxiety disorder that is often diagnosed with comorbid depressive disorder. Therefore, neuroimaging studies investigating PTSD typically include both patients with and without comorbid depression. Differences in activity of the anterior cingulate cortex (ACC) and insula have been shown to differentiate PTSD patients with and without major depressive disorder (MDD). Whether or not comorbid MDD affects resting state functional connectivity of PTSD patients has not been investigated to our knowledge. Here, resting state functional connectivity of PTSD patients with (PTSD+MDD; n=27) and without (PTSD-MDD; n=23) comorbid MDD was investigated. The subgenual ACC and insula were investigated as seed regions. Connectivity between the subgenual ACC and perigenual parts of the ACC was increased in PTSD+MDD versus PTSD-MDD, which may reflect the presence of depressive specific symptoms such as rumination. Functional connectivity of the subgenual ACC with the thalamus was reduced, potentially related to more severe deficits in executive functioning in the PTSD+MDD group versus the PTSD-MDD group. In addition, the PTSD+MDD group showed reduced functional connectivity of the insula with the hippocampus compared to the PTSD-MDD group. However, this cluster was no longer significantly different when PTSD patients that were using medication were excluded from analyses. Thus, resting state functional connectivity of the subgenual ACC can distinguish PTSD+MDD from PTSD-MDD, and this may therefore be used as a neurobiological marker for comorbid MDD in the presence of PTSD. As PTSD+MDD are more treatment resistant, these findings can also guide treatment development, for example by targeting the subgenual ACC network with treatment.

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