Gray Matter Volume Decrease Distinguishes Schizophrenia From Bipolar Offspring During Childhood and Adolescence

2015 ◽  
Vol 54 (8) ◽  
pp. 677-684.e2 ◽  
Author(s):  
Gisela Sugranyes ◽  
Elena de la Serna ◽  
Soledad Romero ◽  
Vanessa Sanchez-Gistau ◽  
Anna Calvo ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Childhood And Adolescence ◽  
Matter Volume ◽  
Volume Decrease

Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study

2005 ◽  
Vol 22 (8) ◽  
pp. 2089-2094 ◽  
Author(s):  
Hanik K. Yoo ◽  
Minue J. Kim ◽  
Seog Ju Kim ◽  
Young Hoon Sung ◽  
Minyoung E. Sim ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Voxel Based Morphometry ◽  
Matter Volume ◽  
Volume Decrease

P 3 Cerebellar gray matter volume decrease is associated with epileptic seizures in multiple sclerosis

2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Epileptic Seizures ◽  
Matter Volume ◽  
Cerebellar Gray Matter ◽  
Volume Decrease

The role of global and regional gray matter volume decrease in multiple sclerosis

2016 ◽  
Vol 263 (6) ◽  
pp. 1137-1145 ◽  
Author(s):  
Matthias Grothe ◽  
Martin Lotze ◽  
Sönke Langner ◽  
Alexander Dressel
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Volume Decrease

scholarly journals Altered gray matter volume and structural co-variance in adolescents with social anxiety disorder: evidence for a delayed and unsynchronized development of the fronto-limbic system

2020 ◽  
pp. 1-10
Author(s):  
Zhen Liu ◽  
Yang Hu ◽  
Yiwen Zhang ◽  
Wenjing Liu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Mental Disorder ◽  
Social Anxiety Disorder ◽  
Gray Matter ◽  
Limbic System ◽  
Gray Matter Volume ◽  
Childhood And Adolescence ◽  
Close Link ◽  
Matter Volume

Abstract Background Social anxiety disorder (SAD) is a prevalent mental disorder diagnosed in childhood and adolescence. Theories regarding brain development and SAD suggest a close link between neurodevelopmental dysfunction at the adolescent juncture and SAD, but direct evidence is rare. This study aims to examine brain structural abnormalities in adolescents with SAD. Methods High-resolution T1-weighted images were obtained from 31 adolescents with SAD (15–17 years) and 42 matching healthy controls (HC). We evaluated symptom severity with the Social Anxiety Scale for Children (SASC) and the Screen for Child Anxiety Related Emotional Disorders (SCARED). We used voxel-based morphometry analysis to detect regional gray matter volume abnormalities and structural co-variance analysis to investigate inter-regional coordination patterns. Results We found significantly higher gray matter volume in the orbitofrontal cortex (OFC) and the insula in adolescents with SAD compared to HC. We also observed significant co-variance of the gray matter volume between the OFC and amygdala, and the OFC and insula in HC, but these co-variance relationships diminished in SAD. Conclusions These findings provide the first evidence that the brain structural deficits in adolescents with SAD are not only in the core regions of the fronto-limbic system, but also represented by the diminished coordination in the development of these regions. The delayed and unsynchronized development pattern of the fronto-limbic system supports SAD as an adolescent-sensitive developmental mental disorder.

scholarly journals Synergistic Effects of Age on Patterns of White and Gray Matter Volume across Childhood and Adolescence

eNeuro ◽  
2015 ◽  
Vol 2 (4) ◽  
pp. ENEURO.0003-15.2015 ◽  
Author(s):  
Signe Bray ◽  
Mark Krongold ◽  
Cassandra Cooper ◽  
Catherine Lebel
Keyword(s):  
Gray Matter ◽  
Synergistic Effects ◽  
Gray Matter Volume ◽  
Childhood And Adolescence ◽  
Matter Volume

scholarly journals Duration of Untreated Psychosis Is Associated with Temporal and Occipitotemporal Gray Matter Volume Decrease in Treatment Naïve Schizophrenia

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83679 ◽  
Author(s):  
Xiaofeng Guo ◽  
Jun Li ◽  
Qinling Wei ◽  
Xiaoduo Fan ◽  
David N. Kennedy ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Duration Of Untreated Psychosis ◽  
Matter Volume ◽  
Treatment Naïve ◽  
Volume Decrease

scholarly journals Gray Matter Volume in the Developing Frontal Lobe and Its Relationship With Executive Function in Late Childhood and Adolescence: A Community-Based Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Dajung Sung ◽  
Bumhee Park ◽  
Bora Kim ◽  
Hayeon Kim ◽  
Kyu-In Jung ◽  
...  
Keyword(s):  
Executive Functions ◽  
Frontal Lobe ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Stroop Test ◽  
Late Childhood ◽  
Childhood And Adolescence ◽  
Structural Development ◽  
Matter Volume ◽  
Wide Range

Background: During late childhood and adolescence, the frontal lobe undergoes critical developmental changes, affecting a wide range of executive functions significantly. Conversely, abnormality in the maturation of the frontal lobe during this period may result in a limited ability to effectively use various executive functions. However, at present, it is still unclear how the structural development of the frontal lobe is associated with different aspects of executive functions during this developmental period. To fill the gap in evidence, we aimed to elucidate gray matter volume (GMV) in the frontal lobe and its relationship with multiple aspects of executive functions in late childhood and adolescence.Methods: We recruited our participants aged between 6 and 17 years to assess GMV in the frontal lobe and its relationship with different domains of executive functions in late childhood and adolescence. We used the voxel-based morphometry–DARTEL procedure to measure GMVs in multiple frontal sub-regions and Stroop test and Advanced Test of Attention (ATA) to measure executive functions. We then conducted partial correlation analyses and performed multiple comparisons with different age and sex groups.Results: Overall, 123 participants took part in our study. We found that many regional GMVs in the frontal lobe were negatively correlated with ATA scores in participants in late childhood and positively correlated with ATA scores in participants in adolescence. Only a few correlations of the GMVs with Stroop test scores were significant in both age groups. Although most of our results did not survive false discovery rate (FDR) correction (i.e., FDR <0.2), considering their novelty, we discussed our results based on uncorrected p-values. Our findings indicate that the frontal sub-regions that were involved in attentional networks may significantly improve during late childhood and become stabilized later in adolescence. Moreover, our findings with the Stroop test may also present the possibility of the later maturation of higher-order executive functioning skills.Conclusion: Although our findings were based on uncorrected p-values, the novelty of our findings may provide better insights into elucidating the maturation of the frontal lobe and its relationship with the development of attention networks in late childhood and adolescence.

Sign in / Sign up

Export Citation Format

Share Document