The double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy

2016 ◽  
Vol 36 ◽  
pp. 73-85 ◽  
Author(s):  
Jing-Zhang Wang ◽  
Yu-Hua Zhang ◽  
Xin-Hua Guo ◽  
Hong-Yan Zhang ◽  
Yuan Zhang
Keyword(s):  
T Cell ◽  
B Cells ◽  
Cancer Immunotherapy ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Double Edge

scholarly journals Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis

2015 ◽  
Vol 195 (6) ◽  
pp. 2900-2907 ◽  
Author(s):  
Amandeep K. Khera ◽  
Sam Afkhami ◽  
Rocky Lai ◽  
Mangalakumari Jeyanathan ◽  
Anna Zganiacz ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Pulmonary Tuberculosis ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Mucosal Vaccine ◽  
Cell Immunity

scholarly journals On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients

2004 ◽  
Vol 10 (14) ◽  
pp. 4754-4760 ◽  
Author(s):  
Monique van Oijen ◽  
Adriaan Bins ◽  
Sjoerd Elias ◽  
Johan Sein ◽  
Pauline Weder ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Advanced Stage ◽  
Cell Immunity ◽  
Melanoma Patients

Role of T cell immunity in hepatitis C virus infections

2013 ◽  
Vol 3 (4) ◽  
pp. 461-467 ◽  
Author(s):  
Mark AA Claassen ◽  
Harry LA Janssen ◽  
André Boonstra
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
T Cell Immunity ◽  
Virus Infections ◽  
Cell Immunity

scholarly journals Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression

2011 ◽  
Vol 17 (15) ◽  
pp. 4987-4995 ◽  
Author(s):  
Qiao Li ◽  
Xiangming Lao ◽  
Qin Pan ◽  
Ning Ning ◽  
Ji Yet ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Adoptive Transfer ◽  
Tumor Regression ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals Critical role of protein glycosylation in T cell immunity/autoimmunity

2010 ◽  
Vol 69 (Suppl 2) ◽  
pp. A71-A72 ◽  
Author(s):  
T G Szabo ◽  
R Palotai ◽  
P Antal ◽  
I Tokatly ◽  
L Tothfalusi ◽  
...  
Keyword(s):  
T Cell ◽  
Critical Role ◽  
Protein Glycosylation ◽  
T Cell Immunity ◽  
Cell Immunity

Regulation of T-cell migration by co-stimulatory molecules

2007 ◽  
Vol 35 (5) ◽  
pp. 1114-1118 ◽  
Author(s):  
R. David ◽  
F.M. Marelli-Berg
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
T Cell Receptor ◽  
Antigenic Site ◽  
Cell Receptor ◽  
T Cell Immunity ◽  
T Cell Migration ◽  
Cell Immunity ◽  
Essential Contribution

Migration of primed T-cells to the antigenic site is an essential event in the development of effective immunity. This process is tightly regulated in order to ensure efficient and specific responses. Most studies have focused on non-specific mediators of T-cell migration, including integrins and chemokines. However, recent studies have highlighted the key role of the T-cell receptor and co-stimulatory molecules in guiding T-cell access to antigenic tissue. Here, we review the experimental evidence for an essential contribution of co-stimulation-mediated molecular interactions regulating T-cell migration in the development of T-cell immunity and tolerance.

scholarly journals Human Wharton's jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lijie Pan ◽  
Chang Liu ◽  
Qiuli Liu ◽  
Yanli Li ◽  
Cong Du ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cell ◽  
Fulminant Hepatitis ◽  
Wharton’S Jelly ◽  
T Cell Immunity ◽  
Human Umbilical Cord ◽  
Con A ◽  
Wharton's Jelly ◽  
Cell Immunity

Abstract Background Fulminant hepatitis is a severe life-threatening clinical condition with rapid progressive loss of liver function. It is characterized by massive activation and infiltration of immune cells into the liver and disturbance of inflammatory cytokine production. Mesenchymal stem cells (MSCs) showed potent immunomodulatory properties. Transplantation of MSCs is suggested as a promising therapeutic approach for a host of inflammatory conditions. Methods In the current study, a well-established concanavalin A (Con A)-induced fulminant hepatitis mouse model was used to investigate the effects of transplanting human umbilical cord Wharton's jelly-derived MSCs (hWJ-MSCs) on fulminant hepatitis. Results We showed that hWJ-MSCs effectively alleviate fulminant hepatitis in mouse models, primarily through inhibiting T cell immunity. RNA sequencing of liver tissues and human T cells co-cultured with hWJ-MSCs showed that NF-κB signaling and glycolysis are two main pathways mediating the protective role of hWJ-MSCs on both Con A-induced hepatitis in vivo and T cell activation in vitro. Conclusion In summary, our data confirmed the potent therapeutic role of MSCs-derived from Wharton's jelly of human umbilical cord on Con A-induced fulminant hepatitis, and uncovered new mechanisms that glycolysis metabolic shift mediates suppression of T cell immunity by hWJ-MSCs.

Innate T-Cell Immunity in HIV Infections: The Role of Vg9Vd2 T Lymphocytes

2002 ◽  
Vol 2 (8) ◽  
pp. 769-781 ◽  
Author(s):  
F. Poccia ◽  
M.- Gougeon ◽  
C. Agrati ◽  
C. Montesano ◽  
F. Martini ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Hiv Infections ◽  
T Cell Immunity ◽  
Cell Immunity
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