Regulation of T-cell migration by co-stimulatory molecules

2007 ◽  
Vol 35 (5) ◽  
pp. 1114-1118 ◽  
Author(s):  
R. David ◽  
F.M. Marelli-Berg
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
T Cell Receptor ◽  
Antigenic Site ◽  
Cell Receptor ◽  
T Cell Immunity ◽  
T Cell Migration ◽  
Cell Immunity ◽  
Essential Contribution

Migration of primed T-cells to the antigenic site is an essential event in the development of effective immunity. This process is tightly regulated in order to ensure efficient and specific responses. Most studies have focused on non-specific mediators of T-cell migration, including integrins and chemokines. However, recent studies have highlighted the key role of the T-cell receptor and co-stimulatory molecules in guiding T-cell access to antigenic tissue. Here, we review the experimental evidence for an essential contribution of co-stimulation-mediated molecular interactions regulating T-cell migration in the development of T-cell immunity and tolerance.

T-cell receptor transfer for boosting HIV-1-specific T-cell immunity in HIV-1-infected patients

AIDS ◽  
2016 ◽  
Vol 30 (14) ◽  
pp. 2149-2158 ◽  
Author(s):  
Christiane Mummert ◽  
Christian Hofmann ◽  
Angela G. Hückelhoven ◽  
Silke Bergmann ◽  
Sandra M. Mueller-Schmucker ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Hiv 1

scholarly journals Rac Activation by the T-Cell Receptor Inhibits T Cell Migration

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12393 ◽  
Author(s):  
Eva Cernuda-Morollón ◽  
Jaime Millán ◽  
Mark Shipman ◽  
Federica M. Marelli-Berg ◽  
Anne J. Ridley
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Migration

scholarly journals Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia

2017 ◽  
Vol 7 (3) ◽  
pp. e1405204 ◽  
Author(s):  
Takero Shindo ◽  
Kazutaka Kitaura ◽  
Hiroshi Ureshino ◽  
Kazuharu Kamachi ◽  
Masaharu Miyahara ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Deep Sequencing ◽  
Cell Receptor ◽  
T Cell Immunity ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Cell Immunity

scholarly journals On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients

2004 ◽  
Vol 10 (14) ◽  
pp. 4754-4760 ◽  
Author(s):  
Monique van Oijen ◽  
Adriaan Bins ◽  
Sjoerd Elias ◽  
Johan Sein ◽  
Pauline Weder ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Advanced Stage ◽  
Cell Immunity ◽  
Melanoma Patients

scholarly journals Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells

2021 ◽  
Vol 22 (5) ◽  
pp. 2713
Author(s):  
Sun-Hye Shin ◽  
Kyung-Ah Cho ◽  
Hee-Soo Yoon ◽  
So-Yeon Kim ◽  
Hee-Yeon Kim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd4 T Cells ◽  
Acyl Chain ◽  
Signal Strength ◽  
Cell Receptor ◽  
Ceramide Synthase ◽  
Asthmatic Patients

(1) Background: six mammalian ceramide synthases (CerS1–6) determine the acyl chain length of sphingolipids (SLs). Although ceramide levels are increased in murine allergic asthma models and in asthmatic patients, the precise role of SLs with specific chain lengths is still unclear. The role of CerS2, which mainly synthesizes C22–C24 ceramides, was investigated in immune responses elicited by airway inflammation using CerS2 null mice. (2) Methods: asthma was induced in wild type (WT) and CerS2 null mice with ovalbumin (OVA), and inflammatory cytokines and CD4 (cluster of differentiation 4)+ T helper (Th) cell profiles were analyzed. We also compared the functional capacity of CD4+ T cells isolated from WT and CerS2 null mice. (3) Results: CerS2 null mice exhibited milder symptoms and lower Th2 responses than WT mice after OVA exposure. CerS2 null CD4+ T cells showed impaired Th2 and increased Th17 responses with concomitant higher T cell receptor (TCR) signal strength after TCR stimulation. Notably, increased Th17 responses of CerS2 null CD4+ T cells appeared only in TCR-mediated, but not in TCR-independent, treatment. (4) Conclusions: altered Th2/Th17 immune response with higher TCR signal strength was observed in CerS2 null CD4+ T cells upon TCR stimulation. CerS2 and very-long chain SLs may be therapeutic targets for Th2-related diseases such as asthma.

scholarly journals The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

2018 ◽  
Vol 9 ◽  
Author(s):  
Kannan Natarajan ◽  
Jiansheng Jiang ◽  
Nathan A. May ◽  
Michael G. Mage ◽  
Lisa F. Boyd ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Molecular Flexibility

scholarly journals Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Yan Xu ◽  
Ling Xu ◽  
Cunte Chen ◽  
Yikai Zhang ◽  
Chengwu Zeng ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Sharp Decrease ◽  
Cell Receptor ◽  
Cell Immune Response ◽  
Immune Senescence ◽  
Receptor Repertoire ◽  
Age Related ◽  
Cell Immunity ◽  
Group I

Background. T cell immunity plays a central role in the body’s defense system, including maintaining homeostasis and preventing tumorigenesis and viral infection. Immune system functions degenerate with age, leading to immune senescence. Physiologically, immune senescence is characterized by a decrease in T cell receptor diversity, naive T cell deficiency, and alterations in T cell immune-related miRNAs. However, little is known about the characteristics of T cell immunosenescence in Chinese individuals. Results. A significant decrease in the miR-17, miR-92a, and miR-181a levels in PBMCs was detected with age. The miR-92a and miR-181a levels were upregulated in CBMCs when comparing healthy individuals to group I (0~9 years), whereas miR-17 was downregulated. The sjTREC level in PBMCs was negatively correlated with age, and a sharp decrease in sjTRECs was found between groups I and II (10~19 years). Twenty-four TCR Vβ subfamilies could be detected in most samples, and most displayed polyclonality, while skewed expression of the Vβ subfamilies as well as an increased oligoclonal tendency was found with age. Similarly, the frequencies of the TCR Vγ and Vδ subfamilies decreased with age, and the alteration in clonality appeared to be stable at different ages. Conclusion. We made the novel observation of T cell immunosenescence with age in Chinese individuals, which may provide information for immune targets to enhance the T cell immune response in immunotherapy settings for elderly patients.

scholarly journals T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells

2001 ◽  
Vol 194 (10) ◽  
pp. 1473-1483 ◽  
Author(s):  
Isabel Ferrero ◽  
Anne Wilson ◽  
Friedrich Beermann ◽  
Werner Held ◽  
H. Robson MacDonald
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Biology ◽  
Γδ T Cells ◽  
Cell Receptor ◽  
Wild Type ◽  
Normal Numbers ◽  
T Cell Biology

A particular feature of γδ T cell biology is that cells expressing T cell receptor (TCR) using specific Vγ/Vδ segments are localized in distinct epithelial sites, e.g., in mouse epidermis nearly all γδ T cells express Vγ3/Vδ1. These cells, referred to as dendritic epidermal T cells (DETC) originate from fetal Vγ3+ thymocytes. The role of γδ TCR specificity in DETC's migration/localization to the skin has remained controversial. To address this issue we have generated transgenic (Tg) mice expressing a TCR δ chain (Vδ6.3-Dδ1-Dδ2-Jδ1-Cδ), which can pair with Vγ3 in fetal thymocytes but is not normally expressed by DETC. In wild-type (wt) Vδ6.3Tg mice DETC were present and virtually all of them express Vδ6.3. However, DETC were absent in TCR-δ−/− Vδ6.3Tg mice, despite the fact that Vδ6.3Tg γδ T cells were present in normal numbers in other lymphoid and nonlymphoid tissues. In wt Vδ6.3Tg mice, a high proportion of in-frame Vδ1 transcripts were found in DETC, suggesting that the expression of an endogenous TCR-δ (most probably Vδ1) was required for the development of Vδ6.3+ epidermal γδ T cells. Collectively our data demonstrate that TCR specificity is essential for the development of γδ T cells in the epidermis. Moreover, they show that the TCR-δ locus is not allelically excluded.

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