scholarly journals Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

Immunity ◽  
2012 ◽  
Vol 37 (3) ◽  
pp. 463-474 ◽  
Author(s):  
Timotheus Y.F. Halim ◽  
Aric MacLaren ◽  
Mark T. Romanish ◽  
Matthew J. Gold ◽  
Kelly M. McNagny ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Allergic Inflammation ◽  
Cell Development ◽  
Helper Cell ◽  
Orphan Nuclear Receptor ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Natural Helper

scholarly journals Cell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX

2000 ◽  
Vol 20 (23) ◽  
pp. 8731-8739 ◽  
Author(s):  
Mime Kobayashi ◽  
Ruth T. Yu ◽  
Kunio Yasuda ◽  
Kazuhiko Umesono
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Ectopic Expression ◽  
Orphan Nuclear Receptor ◽  
Principal Role ◽  
Acid Receptor ◽  
Increased Sensitivity ◽  
Cell Type Specific ◽  
Specific Regulation

ABSTRACT Malformations in the eye can be caused by either an excess or deficiency of retinoids. An early target gene of the retinoid metabolite, retinoic acid (RA), is that encoding one of its own receptors, the retinoic acid receptor β (RARβ). To better understand the mechanisms underlying this autologous regulation, we characterized the chick RARβ2 promoter. The region surrounding the transcription start site of the avian RARβ2 promoter is over 90% conserved with the corresponding region in mammals and confers strong RA-dependent transactivation in primary cultured embryonic retina cells. This response is selective for RAR but not retinoid X receptor-specific agonists, demonstrating a principal role for RAR(s) in retina cells. Retina cells exhibit a far higher sensitivity to RA than do fibroblasts or osteoblasts, a property we found likely due to expression of the orphan nuclear receptor TLX. Ectopic expression of TLX in fibroblasts resulted in increased sensitivity to RA induction, an effect that is conserved between chick and mammals. We have identified a cis element, the silencing element relieved by TLX (SET), within the RARβ2 promoter region which confers TLX- and RA-dependent transactivation. These results indicate an important role for TLX in autologous regulation of the RARβ gene in the eye.

scholarly journals The Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ1 (RORγ1): A Novel Player Determinant of Insulin Sensitivity in Morbid Obesity

Obesity ◽  
2012 ◽  
Vol 20 (3) ◽  
pp. 488-497 ◽  
Author(s):  
Francisco J. Tinahones ◽  
Inmaculada Moreno-Santos ◽  
Joan Vendrell ◽  
M. R. Chacon ◽  
Lourdes Garrido-Sanchez ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Retinoic Acid ◽  
Insulin Sensitivity ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Orphan Nuclear Receptor ◽  
Acid Receptor

scholarly journals Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3

2002 ◽  
Vol 175 (1) ◽  
pp. 33-40 ◽  
Author(s):  
KW Lee ◽  
P Cohen
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Response Element ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Igfbp 3

Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has been shown to be a growth inhibitory, apoptosis-inducing molecule by virtue of its ability to bind IGFs, in addition to previously demonstrated IGF-independent effects. The recent discovery of the interaction between nuclear IGFBP-3 and 9-cis retinoic acid receptor-alpha (retinoid X receptor alpha RXRalpha), a nuclear receptor, and its involvement in the regulation of transcriptional signaling and apoptosis represents an important paradigm shift in the understanding of IGFBP function. RXRalpha is required for the apoptosis-inducing effects of IGFBP-3. IGFBP-3 and RXR ligands are additive in inducing apoptosis in cancer cells. IGFBP-3 has direct effects on gene transcription, as RXR response element reporter signaling was enhanced and the all-trans retinoic acid receptor response element reporter signaling was inhibited. Accumulating evidence further confirms IGF-independent functions of this multifunction binding protein. Other binding proteins, in addition to other members of the IGF axis, have now been described in the nucleus and are postulated to have effects on transcriptional events. Investigation into these new interactions will expose new protein partners in the interface between the nuclear receptor and growth factor pathways and reveal new targets to be exploited in the treatment of cancer and other diseases.

Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers

2013 ◽  
Vol 13 (5) ◽  
pp. 401-408 ◽  
Author(s):  
Samar Alsafadi ◽  
Caroline Even ◽  
Coralie Falet ◽  
Aicha Goubar ◽  
Frédéric Commo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Breast Cancers ◽  
Retinoic Acid Receptor Alpha ◽  
Acid Sensitivity ◽  
Acid Receptor ◽  
Receptor Alpha
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