scholarly journals Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

2014 ◽  
Vol 66 (3) ◽  
pp. 579-588 ◽  
Author(s):  
Mi Ra Chang ◽  
Brent Lyda ◽  
Theodore M. Kamenecka ◽  
Patrick R. Griffin
Keyword(s):  
Retinoic Acid ◽  
Experimental Model ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Orphan Nuclear Receptor ◽  
Collagen Induced Arthritis ◽  
Acid Receptor

scholarly journals Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

Immunity ◽  
2012 ◽  
Vol 37 (3) ◽  
pp. 463-474 ◽  
Author(s):  
Timotheus Y.F. Halim ◽  
Aric MacLaren ◽  
Mark T. Romanish ◽  
Matthew J. Gold ◽  
Kelly M. McNagny ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Allergic Inflammation ◽  
Cell Development ◽  
Helper Cell ◽  
Orphan Nuclear Receptor ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Natural Helper

scholarly journals Cell-Type-Specific Regulation of the Retinoic Acid Receptor Mediated by the Orphan Nuclear Receptor TLX

2000 ◽  
Vol 20 (23) ◽  
pp. 8731-8739 ◽  
Author(s):  
Mime Kobayashi ◽  
Ruth T. Yu ◽  
Kunio Yasuda ◽  
Kazuhiko Umesono
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Ectopic Expression ◽  
Orphan Nuclear Receptor ◽  
Principal Role ◽  
Acid Receptor ◽  
Increased Sensitivity ◽  
Cell Type Specific ◽  
Specific Regulation

ABSTRACT Malformations in the eye can be caused by either an excess or deficiency of retinoids. An early target gene of the retinoid metabolite, retinoic acid (RA), is that encoding one of its own receptors, the retinoic acid receptor β (RARβ). To better understand the mechanisms underlying this autologous regulation, we characterized the chick RARβ2 promoter. The region surrounding the transcription start site of the avian RARβ2 promoter is over 90% conserved with the corresponding region in mammals and confers strong RA-dependent transactivation in primary cultured embryonic retina cells. This response is selective for RAR but not retinoid X receptor-specific agonists, demonstrating a principal role for RAR(s) in retina cells. Retina cells exhibit a far higher sensitivity to RA than do fibroblasts or osteoblasts, a property we found likely due to expression of the orphan nuclear receptor TLX. Ectopic expression of TLX in fibroblasts resulted in increased sensitivity to RA induction, an effect that is conserved between chick and mammals. We have identified a cis element, the silencing element relieved by TLX (SET), within the RARβ2 promoter region which confers TLX- and RA-dependent transactivation. These results indicate an important role for TLX in autologous regulation of the RARβ gene in the eye.

scholarly journals The Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ1 (RORγ1): A Novel Player Determinant of Insulin Sensitivity in Morbid Obesity

Obesity ◽  
2012 ◽  
Vol 20 (3) ◽  
pp. 488-497 ◽  
Author(s):  
Francisco J. Tinahones ◽  
Inmaculada Moreno-Santos ◽  
Joan Vendrell ◽  
M. R. Chacon ◽  
Lourdes Garrido-Sanchez ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Retinoic Acid ◽  
Insulin Sensitivity ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Orphan Nuclear Receptor ◽  
Acid Receptor

scholarly journals Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α

2021 ◽  
Author(s):  
Ji Min Lee ◽  
Hyunkyung Kim ◽  
Sung Hee Baek
Keyword(s):  
Retinoic Acid ◽  
Molecular Mechanisms ◽  
Cancer Metabolism ◽  
Metabolic Diseases ◽  
Retinoic Acid Receptor ◽  
Critical Role ◽  
Orphan Receptor ◽  
Orphan Nuclear Receptor ◽  
Functional Link ◽  
Acid Receptor

AbstractRetinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including RORα, plays a critical role in tumorigenesis and facilitates the development of inflammatory hallmarks. Although RORα contributes to overall fitness among anticancer, anti-inflammatory, lipid homeostasis, and circadian clock mechanisms, the molecular mechanisms underlying the mode of transcriptional regulation by RORα remain unclear. Nonetheless, RORα has important implications for pharmacological prevention of cancer, inflammation, and metabolic diseases, and understanding context-dependent RORα regulation will provide an innovative approach for unraveling the functional link between cancer metabolism and rhythm changes.

scholarly journals OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor.

1995 ◽  
Vol 92 (6) ◽  
pp. 2096-2100 ◽  
Author(s):  
M. Teboul ◽  
E. Enmark ◽  
Q. Li ◽  
A. C. Wikstrom ◽  
M. Pelto-Huikko ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptor ◽  
Retinoic Acid Receptor ◽  
Nuclear Receptor Superfamily ◽  
Acid Receptor
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