Complement C5 controls liver lipid profile, promotes liver homeostasis and inflammation in C57BL/6 genetic background

Immunobiology ◽  
2016 ◽  
Vol 221 (7) ◽  
pp. 822-832 ◽  
Author(s):  
Lorena Bavia ◽  
Íris Arantes de Castro ◽  
Bruno Cogliati ◽  
Juliano Bertollo Dettoni ◽  
Venancio Avancini Ferreira Alves ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Genetic Background ◽  
Liver Lipid

scholarly journals Effects of Bioactive Components of Sea Cucumber on the Serum, Liver Lipid Profile and Lipid Absorption

2012 ◽  
Vol 76 (12) ◽  
pp. 2214-2218 ◽  
Author(s):  
Xiao-Qian HU ◽  
Jie XU ◽  
Yong XUE ◽  
Zhao-Jie LI ◽  
Jing-Feng WANG ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Sea Cucumber ◽  
Liver Lipid ◽  
Lipid Absorption ◽  
Bioactive Components

scholarly journals C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Lorena Bavia ◽  
Íris Arantes de Castro ◽  
Lourdes Isaac
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Genetic Background ◽  
Inflammatory Responses ◽  
Liver Lipid ◽  
Liver Steatosis ◽  
Public Health Issue ◽  
Mouse Strains ◽  
Mice Liver

Alcoholic liver disease (ALD) is an important worldwide public health issue characterized by liver steatosis, inflammation, necrosis, and apoptosis of hepatocytes with eventual development of fibrosis and cirrhosis. Comparison of murine models with different inflammatory responses for ALD is important for an evaluation of the importance of genetic background in the interpretation of ethanol-induced phenotypes. Here, we investigated the role of inflammation and genetic background for the establishment of ALD using two different mouse strains: C57BL/6 (B6) and A/J. B6 and A/J mice were treated with a high fat diet containing ethanol (HFDE) and compared to the controls for 10 weeks. Hepatomegaly and steatohepatitis were similar in B6 and A/J mice, but only A/J mice were resistant to weight gain. On the other hand, HFDE-fed B6 accumulated more triglycerides (TG) and cholesterol and presented more intense cellular infiltrate in the liver when compared to HFDM-fed mice. Liver inflammatory environment was distinct in these two mouse strains. While HFDE-fed B6 produced more liver IL-12, A/J mice increased the TNF-αproduction. We concluded that mouse genetic background could dictate the intensity of the HFDE-induced liver injury.

scholarly journals Palm Oil and Egusi Melon Oil Lower Serum and Liver Lipid Profile and Improve Antioxidant Activity in Rats Fed a High Fat Diet

2010 ◽  
Vol 8 (4) ◽  
pp. 154-158
Author(s):  
George O. Eidangbe ◽  
Godwin C. Ojieh ◽  
Blessing O. Idonije ◽  
Olarewaju M. Oluba
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Liver Lipid ◽  
High Fat ◽  
Lower Serum

scholarly journals Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

2017 ◽  
Author(s):  
Rodrigo M. Pereira ◽  
José Diego Botezelli ◽  
Kellen Cristina Da Cruz Rodrigues ◽  
Dennys Esper Cintra ◽  
José Rodrigo Pauli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Physical Exercise ◽  
Inflammatory Response ◽  
Lipid Profile ◽  
Redox State ◽  
Liver Lipid ◽  
Hepatic Metabolism ◽  
Exercise Protocol ◽  
Markers Of Inflammation

Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (HDL increase and decrease TG and LDL levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength or a combination of both is essential for attenuating the complications developed by the consumption of fructose.

Effect of Sesame Oil on Serum and Liver Lipid Profile in Hyperlipidemic Rats.

2014 ◽  
Vol 43 (1) ◽  
pp. 17 ◽  
Author(s):  
Nabil Taha ◽  
Abd Mandour ◽  
Mahdy Korshium ◽  
Mohamed Lebda ◽  
Rasha Emarha
Keyword(s):  
Lipid Profile ◽  
Liver Lipid ◽  
Sesame Oil

Effects of ovariectomy and resistance training on lipid content in skeletal muscle, liver, and heart; fat depots; and lipid profile

2009 ◽  
Vol 34 (6) ◽  
pp. 1079-1086 ◽  
Author(s):  
Richard Diego Leite ◽  
Jonato Prestes ◽  
Celene Fernandes Bernardes ◽  
Gilberto Eiji Shiguemoto ◽  
Guilherme Borges Pereira ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Lipid Profile ◽  
Lipid Content ◽  
Liver Lipid ◽  
Atherogenic Index ◽  
Ovariectomized Rats ◽  
Muscle Lipid ◽  
Liver Lipid Content ◽  
Fat Depots

The aim of the present study was to investigate the effects of resistance training on skeletal muscle lipid content, liver lipid content, heart lipid content, fat depots, and lipid profile in ovariectomized rats. Wistar adult female rats were divided into 4 groups (n = 10 per group): sedentary (Sed-Intact), sedentary ovariectomized (Sed-Ovx), strength trained (ChronicEx-intact), and strength trained ovariectomized (ChronicEx-Ovx). A 12-week strength-training period was used, during which the animals climbed a 1.1-m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with 4–9 climbs and 8–12 dynamic movements per climb. Ovariectomy increased liver lipid content and fat depots, and heart and muscle lipid content. There was an increase in the atherogenic index and a negative change in lipid profile because of the ovariectomy. Resistance training decreased lipid content in the liver, soleus, and tibialis anterior, decreased fat depots (mesenteric and retroperitoneal), and changed the lipid profile, independently of ovarian hormone status. These results indicate the potential benefits of resistance training as an alternative strategy to control the effects of ovariectomy on fat depot, lipid profile, and tissue lipid content.

scholarly journals GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Azadehalsadat Hosseini Dastgerdi ◽  
Mohammadreza Sharifi ◽  
Nepton Soltani
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Liver Lipid ◽  
Liver Glycogen ◽  
Tolerance Test ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Insulin Tolerance ◽  
Liver Insulin Resistance

AbstractThis study investigated the role of GABA in attenuating liver insulin resistance (IR) in type 2 diabetes parents and reducing its risk in their descendants’ liver. Both sexes’ rats were divided into four groups of non-diabetic control, diabetic control (DC), GABA-treated (GABA), and insulin-treated (Ins). The study duration lasted for six months and the young animals followed for four months. Consequently, hyperinsulinemic-euglycemic clamp was performed for all animals. Apart from insulin tolerance test (ITT), serum and liver lipid profile were measured in all groups. Glycogen levels, expression of Foxo1, Irs2, Akt2, and Pepck genes in the liver were assessed for all groups. Overall, GABA improved ITT, increased liver glycogen levels and decreased lipid profile, blood glucose level, and HbA1c in parents and their offspring in compared to the DC group. GIR also increased in both parents and their offspring by GABA. Moreover, the expression of Foxo1, Irs2, Akt2, and Pepck genes improved in GABA-treated parents and their descendants in compared to DC group. Results indicated that GABA reduced liver IR in both parents and their offspring via affecting their liver insulin signaling and gluconeogenesis pathways.

scholarly journals Effects of hookah smoking on liver functions, lipid profile, and adult blood count

Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 763-767
Author(s):  
Muna Yaseen ◽  
Sami Alkubaisy ◽  
Marwan Mahmood Saleh
Keyword(s):  
Lipid Profile ◽  
Liver Lipid ◽  
Future Research ◽  
Blood Samples ◽  
Wide Range ◽  
Liver Functions ◽  
Hookah Smoking ◽  
History Survey ◽  
The Relationship ◽  
Rule Out

Introduction and Aim: Smoking is the most common habit and the largest health risk among people who have an impact on the human body. The goal of our study was to examine the effects of hookah (Shisha) on the liver, lipid profile, and blood content in adult smokers to adult non-smokers.   Materials and Methods: A total of 50 men between the ages of 30 and 60 years took part in the study. These samples were divided into two groups: 30 smokers and 20 non-smokers. Every male is subjected to a complete medical history survey as well as frequent tests to rule out any underlying illnesses or diseases. Blood samples were taken in quantities of 10 mL to examine the blood.  Blood samples were placed on the red roof when blood samples were used with anticoagulant factor. The identification of biological parameters was done using enzyme methods and a Random kit.   Results: The results showed that Hb, PCV, WBC, ESR, platelets, and RBC were all elevated, whereas ALP and transaminase enzymes were not. Although not significantly, TC and TG increased the lipid profile findings. Our analysis yielded a wide range of outcomes. Various factors could be to blame for these disparities.   Conclusion: We describe how future research will focus on the relationship between organ functions and their working tests for smoking effects based on our findings. Age, sex, nutrition, and hereditary behavior must all be included in future studies.

A study of plasma and liver lipid profile of rats fed palm oil or safflower oil along with cholesterol

1994 ◽  
Vol 14 (2) ◽  
pp. 255-269 ◽  
Author(s):  
S. Purushothama ◽  
K. narasimhamurthy ◽  
P.L. Raina ◽  
K. Hariharan
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
Liver Lipid ◽  
Safflower Oil
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