scholarly journals Radiation-Induced Optic Neuropathy Following High-Dose Pencil Beam Scanning Proton Therapy in Skull Base Tumors: A Retrospective Study of 157 Patients

2016 ◽  
Vol 96 (2) ◽  
pp. S65 ◽  
Author(s):  
M. Kountouri ◽  
R.A. Schneider ◽  
M. Walser ◽  
L. Vinante ◽  
F. Fiumedinisi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Skull Base ◽  
Optic Neuropathy ◽  
Proton Therapy ◽  
High Dose ◽  
Pencil Beam ◽  
Skull Base Tumors ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Radiation Induced

scholarly journals Radiation-induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours

2020 ◽  
Vol 93 (1107) ◽  
pp. 20190028 ◽  
Author(s):  
Melpomeni Kountouri ◽  
Alessia Pica ◽  
Marc Walser ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Head And Neck ◽  
Skull Base ◽  
Optic Neuropathy ◽  
Proton Therapy ◽  
High Dose ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Optic Chiasma ◽  
Pencil Beam Scanning ◽  
Radiation Induced

Objective: To assess the radiation-induced optic neuropathy (RION) prevalence, following high dose pencil beam scanning proton therapy (PBSPT) to skull base and head and neck (H&N) tumours Methods: Between 1999 and 2014, 216 adult patients, median age 47 years (range, 18–77), were treated with PBS PT for skull base or H&N malignancies, delivering ≥45 GyRBE to the optic nerve(s) (ON) and/or optic chiasma (OC). The median administered dose to the planning target volume was 74.0 GyRBE (range, 54.0–77.4). The median follow-up was 5.3 years (range, 0.8–15.9). Results: RION was observed in 14 (6.5%) patients at a median time of 13.2 months (range, 4.8–42.6) following PBSPT. Most (92.9%) of RION were symptomatic. Most affected patients (11/14; 79%) developed unilateral toxicity. Grade 4, 3, 2 and 1 toxicity was observed in 10, 2, 1 and 1 patients, respectively. On univariate analyses, age (<70 vs ≥70 years; p < 0.0001), hypertension (p = 0.0007) and tumour abutting the optic apparatus (p = 0.012) were associated with RION. OC’s V60 GyRBE was of border line significance (p = 0.06). None of the other evaluated OC–ON dose/volume metrics (Dmax, Dmean, V40-60) were significantly associated with this complication. Conclusion: These data suggest that high-dose PBS PT for skull base and H&N tumours is associated with a low prevalence of RION. Caution should be however exercised when treating elderly/hypertensive patients with tumours abutting the optic apparatus. Advances in knowledge: This is the first study reporting the risk of developing RION following proton therapy with PBS technique, demonstrating the safety of this treatment.

scholarly journals Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors

2018 ◽  
Vol 129 (6) ◽  
pp. 1313-1317 ◽  
Author(s):  
Jonathan E. Leeman ◽  
Nancy Y. Lee ◽  
Ying Zhou ◽  
Brian Neal ◽  
Kevin Sine ◽  
...  
Keyword(s):  
Skull Base ◽  
Endoscopic Resection ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Skull Base Tumors ◽  
Beam Scanning ◽  
Pencil Beam Scanning

Outcomes of adolescents and young adults treated for brain and skull base tumors with pencil beam scanning proton therapy

2020 ◽  
Vol 67 (12) ◽  
Author(s):  
Pei S. Lim ◽  
Sébastien Tran ◽  
Stephanie G.C. Kroeze ◽  
Alessia Pica ◽  
Jan Hrbacek ◽  
...  
Keyword(s):  
Young Adults ◽  
Skull Base ◽  
Proton Therapy ◽  
Adolescents And Young Adults ◽  
Pencil Beam ◽  
Skull Base Tumors ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals Commissioning of a clinical pencil beam scanning proton therapy unit for ultra‐high dose rates (FLASH)

2021 ◽  
Author(s):  
Konrad P. Nesteruk ◽  
Michele Togno ◽  
Martin Grossmann ◽  
Anthony J. Lomax ◽  
Damien C. Weber ◽  
...  
Keyword(s):  
Proton Therapy ◽  
High Dose ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Dose Rates ◽  
Pencil Beam Scanning

Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy

2016 ◽  
Vol 120 (1) ◽  
pp. 169-174 ◽  
Author(s):  
Damien C. Weber ◽  
Robert Malyapa ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
Ulrike Kliebsch ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Low Grade ◽  
Pencil Beam ◽  
Long Term Outcomes ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Lucas Basler ◽  
Robert Poel ◽  
Christina Schröder ◽  
Alessandra Bolsi ◽  
Antony Lomax ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Dosimetric Analysis ◽  
Skull Base Chordoma ◽  
Patterns Of Recurrence ◽  
Initial Target

Abstract Background Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patterns of recurrence and correlate LR with a detailed dosimetric analysis. Methods 222 patients were treated with proton radiotherapy for chordoma (n = 151) and chondrosarcoma (n = 71) at the PSI between 1998 and 2012. All patients underwent surgery, followed by pencil-beam scanning proton therapy to a mean dose of 72.5 ± 2.2GyRBE. A retrospective patterns of recurrence analysis was performed: LR were contoured on follow-up MRI, registered with planning-imaging and the overlap with initial target structures (GTV, PTVhigh-dose, PTVlow-dose) was calculated. DVH parameters of planning structures and recurrences were calculated and correlated with LR using univariate and multivariate cox regression. Results After a median follow-up of 50 months, 35 (16%) LR were observed. Follow-up MRI imaging was available for 27 (77%) of these recurring patients. Only one (3.7%) recurrence was located completely outside the initial PTV (surgical pathway recurrence). The mean proportions of LR covered by the initial target structures were 48% (range 0–86%) for the GTV, 70% (range 0–100%) for PTVhigh and 83% (range 0–100%) for PTVlow. In the univariate analysis, the following DVH parameters were significantly associated with LR: GTV(V < 66GyRBE, p = 0.01), GTV(volume, p = 0.02), PTVhigh(max, p = 0.02), PTVhigh(V < 66GyRBE, p = 0.03), PTVhigh(V < 59GyRBE, p = 0.02), PTVhigh(volume, p = 0.01) and GTV(D95, p = 0.05). In the multivariate analysis, only histology (chordoma vs. chondrosarcoma, p = 0.01), PTVhigh(volume, p = 0.05) and GTV(V < 66GyRBE, p = 0.02) were independent prognostic factors for LR. Conclusion This study identified DVH parameters, which are associated with the risk of local recurrence after proton therapy using pencil-beam scanning for patients with skull-base chordoma and chondrosarcoma.

scholarly journals Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute

2015 ◽  
Vol 18 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Damien C. Weber ◽  
Shahed Badiyan ◽  
Robert Malyapa ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Pencil Beam ◽  
Long Term Outcomes ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Paul Scherrer
Sign in / Sign up

Export Citation Format

Share Document