scholarly journals Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors

2018 ◽  
Vol 129 (6) ◽  
pp. 1313-1317 ◽  
Author(s):  
Jonathan E. Leeman ◽  
Nancy Y. Lee ◽  
Ying Zhou ◽  
Brian Neal ◽  
Kevin Sine ◽  
...  
Keyword(s):  
Skull Base ◽  
Endoscopic Resection ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Skull Base Tumors ◽  
Beam Scanning ◽  
Pencil Beam Scanning

Outcomes of adolescents and young adults treated for brain and skull base tumors with pencil beam scanning proton therapy

2020 ◽  
Vol 67 (12) ◽  
Author(s):  
Pei S. Lim ◽  
Sébastien Tran ◽  
Stephanie G.C. Kroeze ◽  
Alessia Pica ◽  
Jan Hrbacek ◽  
...  
Keyword(s):  
Young Adults ◽  
Skull Base ◽  
Proton Therapy ◽  
Adolescents And Young Adults ◽  
Pencil Beam ◽  
Skull Base Tumors ◽  
Beam Scanning ◽  
Pencil Beam Scanning

Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy

2016 ◽  
Vol 120 (1) ◽  
pp. 169-174 ◽  
Author(s):  
Damien C. Weber ◽  
Robert Malyapa ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
Ulrike Kliebsch ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Low Grade ◽  
Pencil Beam ◽  
Long Term Outcomes ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Lucas Basler ◽  
Robert Poel ◽  
Christina Schröder ◽  
Alessandra Bolsi ◽  
Antony Lomax ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Dosimetric Analysis ◽  
Skull Base Chordoma ◽  
Patterns Of Recurrence ◽  
Initial Target

Abstract Background Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patterns of recurrence and correlate LR with a detailed dosimetric analysis. Methods 222 patients were treated with proton radiotherapy for chordoma (n = 151) and chondrosarcoma (n = 71) at the PSI between 1998 and 2012. All patients underwent surgery, followed by pencil-beam scanning proton therapy to a mean dose of 72.5 ± 2.2GyRBE. A retrospective patterns of recurrence analysis was performed: LR were contoured on follow-up MRI, registered with planning-imaging and the overlap with initial target structures (GTV, PTVhigh-dose, PTVlow-dose) was calculated. DVH parameters of planning structures and recurrences were calculated and correlated with LR using univariate and multivariate cox regression. Results After a median follow-up of 50 months, 35 (16%) LR were observed. Follow-up MRI imaging was available for 27 (77%) of these recurring patients. Only one (3.7%) recurrence was located completely outside the initial PTV (surgical pathway recurrence). The mean proportions of LR covered by the initial target structures were 48% (range 0–86%) for the GTV, 70% (range 0–100%) for PTVhigh and 83% (range 0–100%) for PTVlow. In the univariate analysis, the following DVH parameters were significantly associated with LR: GTV(V < 66GyRBE, p = 0.01), GTV(volume, p = 0.02), PTVhigh(max, p = 0.02), PTVhigh(V < 66GyRBE, p = 0.03), PTVhigh(V < 59GyRBE, p = 0.02), PTVhigh(volume, p = 0.01) and GTV(D95, p = 0.05). In the multivariate analysis, only histology (chordoma vs. chondrosarcoma, p = 0.01), PTVhigh(volume, p = 0.05) and GTV(V < 66GyRBE, p = 0.02) were independent prognostic factors for LR. Conclusion This study identified DVH parameters, which are associated with the risk of local recurrence after proton therapy using pencil-beam scanning for patients with skull-base chordoma and chondrosarcoma.

scholarly journals Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute

2015 ◽  
Vol 18 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Damien C. Weber ◽  
Shahed Badiyan ◽  
Robert Malyapa ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Pencil Beam ◽  
Long Term Outcomes ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Paul Scherrer

scholarly journals OP18LONG TERM OUTCOMES OF SKULL-BASE LOW-GRADE CHONDROSARCOMA PATIENTS TREATED WITH PENCIL BEAM SCANNING PROTON THERAPY AT THE PAUL SCHERRER INSTITUTE

2015 ◽  
Vol 17 (suppl 8) ◽  
pp. viii3.4-viii3 ◽  
Author(s):  
Damien Charles Weber ◽  
Shahed Badiyan ◽  
Tony Lomax ◽  
Robert Malyapa ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Low Grade ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Paul Scherrer
Sign in / Sign up

Export Citation Format

Share Document