Predictive Significance of Actinin-4 (ACTN4) Gene Expression in Early-Stage Non-Small Cell Lung Cancer (NSCLC)

2014 ◽  
Vol 90 (5) ◽  
pp. S15
Author(s):  
T. Yamada ◽  
K. Honda
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung

Investigating gene expression profile of non-small cell lung cancer

Open Medicine ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. 608-615
Author(s):  
Tõnu Vooder ◽  
Andres Metspalu
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Survival Rate ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Treatment Strategies ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers

AbstractLung cancer is mainly a lifestyle-associated disease with poor prognosis and the lowest five year survival rate of all types of cancer. Lung cancers are divided into two main groups: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Surgical treatment is generally indicated in cases of early stage NSCLC, and those patients treated with radical and aggressive surgery have a somewhat better survival rate. The main problems with lung cancer treatment are due to late diagnosis, rapidly developing drug resistance and side effects of the treatment that are experienced by almost all patients. The next step for distinguishing histologically complicated lung cancers and determining optimal treatment strategies is gene expression analysis. Supported by gene expression data, it is possible to prognosticate the course of the disease.

Survivin gene expression in early-stage non-small cell lung cancer

2003 ◽  
Vol 200 (5) ◽  
pp. 620-626 ◽  
Author(s):  
Monica Falleni ◽  
Caterina Pellegrini ◽  
Antonio Marchetti ◽  
Barbara Oprandi ◽  
Fiamma Buttitta ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Survivin Gene

scholarly journals Apoptosis Gene Expression Profile in Early-Stage non Small Cell Lung Cancer

2010 ◽  
Vol 13 (2) ◽  
pp. 47-52
Author(s):  
S Metodieva ◽  
R Cherneva ◽  
D Nikolova ◽  
G Genchev ◽  
D Petrov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Expression Profile ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Early Stage Nsclc ◽  
Apoptosis Gene

Apoptosis Gene Expression Profile in Early-Stage non Small Cell Lung CancerNon small cell lung cancer (NSCLC) is a highly aggressive malignancy with survival rates limited to some patients in early stages (I and II). Apoptosis resistance is a hallmark of solid tumors that is tightly concerned with their biology. We analyzed the expression of 84 apoptosis-related genes in a group of Bulgarian patients with early-stage NSCLC.RNA samples extracted from 12 early-stage NSCLC patients [five squamous cell carcinomas (SCC) and seven adenocarcinomas (AC)] and eight adjacent non neoplastic pulmonary tissues were used for gene expression analysis. We applied pathway-focused expression profiling of 84 apoptosis-related genes using real-time PCR.Apoptosis-related genes down regulated in NSCLC compared to non tumor lung tissue (p <0.05) included representatives of the tumor necrosis factor (TNF) ligand family [TNF superfamily 8 (TNFSF8)], caspase cascade (CASP8 and CASP10) and caspase recruitment domain (CARD) family (BCL10), the positive apoptosis regulator DAPK1 and BCL2 family member MCL1. The potential of apoptosis-related genes as prognostic and predictive markers should be validated in future studies.

scholarly journals Changes in GPX1, RHOA and NKIRAS1 gene expression profiles as potential diagnostic markers for non-small cell lung cancer

2018 ◽  
pp. 116-120
Author(s):  
И.В. Пронина ◽  
В.И. Логинов ◽  
Д.С. Ходырев ◽  
Т.П. Казубская ◽  
Э.А. Брага
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung ◽  
High Prevalence

Рак лёгкого отличает высокая распространенность и смертность, связанные в значительной степени с отсутствием доступных методов ранней диагностики. Методом количественной ОТ-ПЦР показано повышение в 5 и более раз экспрессии 3 генов хромосомы 3 в большинстве образцов немелкоклеточного рака лёгкого (НМРЛ) и его гистологических подвидов: аденокарциномы легкого (АК) и плоскоклеточного рака легкого (ПРЛ). При использовании комбинации из трех генов RHOA, GPX1 и NKIRAS1 повышение экспрессии детектируется в 85% (33/39) НМРЛ, в том числе в 78% (18/23) ПРЛ и 94% АК (15/16). Интересно, что при анализе пациентов только ранних стадий (I/II) чувствительность предложенного набора генов сохраняется и даже несколько повышается. Lung cancer is distinguished by an extremely high prevalence and a high mortality rate due to its late detection and unavailability of methods for early diagnosis. Changes in gene expression were evaluated using quantitative RT-PCR. Expression of several chromosome 3 genes (specifically, RHOA, GPX1, and NKIRAS1) was shown to be increased 5 or more times in most samples of non-small cell lung cancer (NSCLC) and its histological subtypes, lung adenocarcinoma (AC) and squamous cell lung cancer (SLC). When a combination of three genes, RHOA, GPX1 and NKIRAS1, was used increased expression was detected in 85% (33/39) of NSCLC samples, including 78% (18/23) of SLC samples and 94% of AC (15/16) samples. Interestingly, when only samples from early-stage cancer (I/II) patients were analyzed, the sensitivity of the proposed set of genes was preserved and even somewhat increased.

scholarly journals Gene Expression Meta-Analysis Identifies VDAC1 as a Predictor of Poor Outcome in Early Stage Non-Small Cell Lung Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e14635 ◽  
Author(s):  
Claire Grills ◽  
Puthen V. Jithesh ◽  
Jaine Blayney ◽  
Shu-Dong Zhang ◽  
Dean A. Fennell
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Meta Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Poor Outcome

STEREOTACTIC BODY RADIATION THERAPY FOR EARLY-STAGE NON-SMALL CELL LUNG CANCER

2018 ◽  
Vol 64 (5) ◽  
pp. 638-644
Author(s):  
Andrey Arsenev ◽  
Sergey Novikov ◽  
Sergey Kanaev ◽  
Anton Barchuk ◽  
Andrey Nefedov ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Stereotactic Radiation ◽  
Screening Programs ◽  
Surgical Methods

An active introduction of screening programs potentially leads to a significant increase in the proportion of patients with early forms of non-small cell lung cancer. Surgical treatment, which is the standard of care for localized forms, due to functional limitations can be performed only in 65-70% of patients. The solution to this problem can be found in the improvement of the results of radiotherapy by using modern equipment, the planning systems, improved fractionation schemes and introduction of methods for summing radiation doses. Stereotactic radiotherapy allows high-precision delivery of high radiation dose to tumor with a minimal damage to surrounding healthy tissues. In this literature review based on the analysis of a large number of publications we show that it is not yet possible to make valid conclusions about the effectiveness and safety of stereotactic radiation therapy as an alternative to the surgical methods. It is necessary to plan and conduct randomized trials without further delay taking into account the expected high relevance of the method.

Sign in / Sign up

Export Citation Format

Share Document