Identification of a Chemical Inhibitor of RAD51 that Disrupatients Homologous Recombinational DNA Repair in Human Cells

2011 ◽  
Vol 81 (2) ◽  
pp. S54-S55
Author(s):  
P.P. Connell
Keyword(s):  
Dna Repair ◽  
Human Cells ◽  
Recombinational Dna Repair

scholarly journals Molecular cloning and chromosomal localization of DNA sequences associated with a human DNA repair gene.

1985 ◽  
Vol 5 (2) ◽  
pp. 398-405 ◽  
Author(s):  
J S Rubin ◽  
V R Prideaux ◽  
H F Willard ◽  
A M Dulhanty ◽  
G F Whitmore ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Sequences ◽  
Chromosomal Localization ◽  
Excision Repair ◽  
Repair Process ◽  
Human Cells ◽  
Gene Products ◽  
Repair Gene ◽  
Human Dna ◽  
Dna Repair Gene

The genes and gene products involved in the mammalian DNA repair processes have yet to be identified. Toward this end we made use of a number of DNA repair-proficient transformants that were generated after transfection of DNA from repair-proficient human cells into a mutant hamster line that is defective in the initial incision step of the excision repair process. In this report, biochemical evidence is presented that demonstrates that these transformants are repair proficient. In addition, we describe the molecular identification and cloning of unique DNA sequences closely associated with the transfected human DNA repair gene and demonstrate the presence of homologous DNA sequences in human cells and in the repair-proficient DNA transformants. The chromosomal location of these sequences was determined by using a panel of rodent-human somatic cell hybrids. Both unique DNA sequences were found to be on human chromosome 19.

scholarly journals DNA repair in human cells. Biochemistry of the hereditary diseases Fanconi's anaemia and Cockayne syndrome

1987 ◽  
Vol 165 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Manfred SCHWEIGER ◽  
Bernhard AUER ◽  
Helmut J. BURTSCHER ◽  
Monica HIRSCH-KAUFFMANN ◽  
Helmut KLOCKER ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cockayne Syndrome ◽  
Human Cells ◽  
Hereditary Diseases
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