scholarly journals Rad51, the lead in mitotic recombinational DNA repair, plays a supporting role in budding yeast meiosis

Cell Cycle ◽  
2012 ◽  
Vol 11 (22) ◽  
pp. 4105-4106 ◽  
Author(s):  
Douglas K. Bishop
Keyword(s):  
Dna Repair ◽  
Budding Yeast ◽  
Yeast Meiosis ◽  
Recombinational Dna Repair

scholarly journals Programmed ER fragmentation drives selective ER inheritance and degradation in budding yeast meiosis

2021 ◽  
Author(s):  
George M. Otto ◽  
Tia Cheunkarndee ◽  
Jessica M. Leslie ◽  
Gloria A. Brar
Keyword(s):  
Plasma Membrane ◽  
Cell Differentiation ◽  
Budding Yeast ◽  
Developmentally Regulated ◽  
Selective Degradation ◽  
Cell Plasma ◽  
Membrane Tethering ◽  
Membrane Bound ◽  
Yeast Meiosis ◽  
And Function

AbstractThe endoplasmic reticulum (ER) is a membrane-bound organelle with diverse, essential functions that rely on the maintenance of membrane shape and distribution within cells. ER structure and function are remodeled in response to changes in cellular demand, such as the presence of external stressors or the onset of cell differentiation, but mechanisms controlling ER remodeling during cell differentiation are not well understood. Here, we describe a series of developmentally regulated changes in ER morphology and composition during budding yeast meiosis, a conserved differentiation program that gives rise to gametes. During meiosis, the cortical ER undergoes fragmentation before collapsing away from the plasma membrane at anaphase II. This programmed collapse depends on the meiotic transcription factor Ndt80, conserved ER membrane structuring proteins Lnp1 and reticulons, and the actin cytoskeleton. A subset of ER is retained at the mother cell plasma membrane and excluded from gamete cells via the action of ER-plasma membrane tethering proteins. ER remodeling is coupled to ER degradation by selective autophagy, which is regulated by the developmentally timed expression of the autophagy receptor Atg40. Autophagy relies on ER collapse, as artificially targeting ER proteins to the cortically retained ER pool prevents their degradation. Thus, developmentally programmed changes in ER morphology determine the selective degradation or inheritance of ER subdomains by gametes.

scholarly journals Bacillus subtilisRecO and SsbA are crucial for RecA-mediated recombinational DNA repair

2015 ◽  
Vol 43 (12) ◽  
pp. 5984-5997 ◽  
Author(s):  
Begoña Carrasco ◽  
Tribhuwan Yadav ◽  
Ester Serrano ◽  
Juan C. Alonso
Keyword(s):  
Dna Repair ◽  
Recombinational Dna Repair

Characterization of a Mutant RecA Protein that Facilitates Homologous Genetic Recombination but not Recombinational DNA Repair: RecA423

1996 ◽  
Vol 264 (4) ◽  
pp. 696-712 ◽  
Author(s):  
Koichiro Ishimori ◽  
Suzanne Sommer ◽  
Adriana Bailone ◽  
Masayuki Takahashi ◽  
Michael M. Cox ◽  
...  
Keyword(s):  
Dna Repair ◽  
Genetic Recombination ◽  
Reca Protein ◽  
Recombinational Dna Repair

Recombinational DNA Repair in Eukaryotes

2020 ◽  
pp. 592-603
Author(s):  
John C Game ◽  
Sophia B Chernikova
Keyword(s):  
Dna Repair ◽  
Recombinational Dna Repair

scholarly journals Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast

2019 ◽  
Vol 294 (37) ◽  
pp. 13629-13637 ◽  
Author(s):  
Suzanne J. Admiraal ◽  
Daniel E. Eyler ◽  
Michael R. Baldwin ◽  
Emily M. Brines ◽  
Christopher T. Lohans ◽  
...  
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Budding Yeast ◽  
Base Excision

TOPBP1 takes RADical command in recombinational DNA repair

2016 ◽  
Vol 213 (2) ◽  
pp. 2132OIA2
Author(s):  
Yi Liu ◽  
Marcus B. Smolka
Keyword(s):  
Dna Repair ◽  
Recombinational Dna Repair
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