scholarly journals Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury

2007 ◽  
Vol 67 (2) ◽  
pp. 573-580 ◽  
Author(s):  
Zahid N. Rabbani ◽  
Ines Batinic-Haberle ◽  
Mitchell S. Anscher ◽  
Jie Huang ◽  
Brian J. Day ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Small Molecular Weight ◽  
Term Administration ◽  
Radiation Induced

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury

2002 ◽  
Vol 33 (6) ◽  
pp. 857-863 ◽  
Author(s):  
Zeljko Vujaskovic ◽  
Ines Batinic-Haberle ◽  
Zahid N Rabbani ◽  
Qin-fu Feng ◽  
Song K Kang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Superoxide Dismutase ◽  
Small Molecular Weight ◽  
Radiation Induced

scholarly journals Effect of small molecular weight soybean protein-derived peptide supplementation on attenuating burn injury-induced inflammation and accelerating wound healing in a rat model

RSC Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1247-1259 ◽  
Author(s):  
Fen Zhao ◽  
Wei Liu ◽  
Yonghui Yu ◽  
Xinqi Liu ◽  
Huinan Yin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Rat Model ◽  
Burn Injury ◽  
Soybean Protein ◽  
Burn Injuries ◽  
Small Molecular Weight

The populations most afflicted by burn injuries have limited abilities to support the significant specialized requirements and costs for acute and long-term burn injury care.

Long-Term Administration of a Low-Molecular-Weight Heparin Contributed to Successful Treatment in a Patient With Primary Mediastinal Large B-Cell Lymphoma and Venous Thromboembolism

2007 ◽  
Vol 14 (4) ◽  
pp. 468-471 ◽  
Author(s):  
Akio Mori ◽  
Makoto Ibata ◽  
Shinobu Mashiko ◽  
Yutaka Tsutsumi ◽  
Nobuo Masauzi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Radiation Therapy ◽  
Low Molecular Weight Heparin ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Molecular Weight ◽  
Large B Cell Lymphoma ◽  
Term Administration ◽  
Large B Cell

The case of a 16-year-old girl with primary mediastinal large B-cell lymphoma who had thrombosis in the brachiocephalic, subclavian, and internal jugular veins at presentation is reported. MACOP-B chemotherapy plus radiation therapy could be the first-line strategy, but MACOP-B increases the risk of thrombosis. Although an effective method for initial treatment of venous thromboembolism (VTE) in cancer patients has not been established, recent studies revealed that the administration of a low-molecular-weight heparin (LMWH) was effective for secondary prevention of VTE. Therefore, the patient in this case was treated with MACOP-B plus rituximab followed by radiation therapy, and an LMWH was administered through the course of treatment. She achieved complete remission and never suffered from VTE. This case suggests that long-term administration of an LMWH contributes to the primary improvement and secondary prevention of VTE even in patients who are at high risk for thrombosis.

Effects of heparin and low-molecular-weight heparins on bone mechanical properties in rats

2004 ◽  
Vol 92 (11) ◽  
pp. 940-946 ◽  
Author(s):  
Waldemar Janiec ◽  
Leszek Śliwiński ◽  
Joanna Folwarczna
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Femoral Neck ◽  
Breaking Load ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Bone Mechanical Properties ◽  
Female Wistar Rats ◽  
Term Administration

SummaryLong-term administration of heparin can be associated with development of osteoporosis. The present study was carried out to compare the effects of standard heparin and two low-molecular-weight heparins (nadroparin and enoxaparin) on bone mechanical properties in rats. The experiment was conducted on 3-month-old female Wistar rats. Standard heparin was administered in doses of 1000 or 2000 IU/kg sc daily, nadroparin and enoxaparin were administered in doses of 1000 or 2000 anti-Xa IU/kg sc daily, for 28 days. Bone mass, length, diameter, mineral content and mechanical properties of the whole femur (extrinsic stiffness, ultimate and breaking load, deformation caused by the applied load) and the femoral neck (load at fracture) were examined. Standard heparin (2000 IU/kg sc daily) weakened the femoral neck. Enoxaparin and the higher doses of standard heparin and nadroparin induced similar unfavourable changes in mechanical properties of the whole femur; the changes were noticeable the most after administration of enoxaparin.

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