scholarly journals Changes in Bone Density during Long-Term Administration of Low-Molecular-Weight Heparins or Acenocoumarol for Secondary Prophylaxis of Venous Thromboembolism

2003 ◽  
Vol 33 (2) ◽  
pp. 64-67 ◽  
Author(s):  
L. Wawrzyńska ◽  
W.Z. Tomkowski ◽  
J. Przedlacki ◽  
B. Hajduk ◽  
A. Torbicki
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Bone Density ◽  
Secondary Prophylaxis ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Term Administration

Effects of heparin and low-molecular-weight heparins on bone mechanical properties in rats

2004 ◽  
Vol 92 (11) ◽  
pp. 940-946 ◽  
Author(s):  
Waldemar Janiec ◽  
Leszek Śliwiński ◽  
Joanna Folwarczna
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Femoral Neck ◽  
Breaking Load ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Bone Mechanical Properties ◽  
Female Wistar Rats ◽  
Term Administration

SummaryLong-term administration of heparin can be associated with development of osteoporosis. The present study was carried out to compare the effects of standard heparin and two low-molecular-weight heparins (nadroparin and enoxaparin) on bone mechanical properties in rats. The experiment was conducted on 3-month-old female Wistar rats. Standard heparin was administered in doses of 1000 or 2000 IU/kg sc daily, nadroparin and enoxaparin were administered in doses of 1000 or 2000 anti-Xa IU/kg sc daily, for 28 days. Bone mass, length, diameter, mineral content and mechanical properties of the whole femur (extrinsic stiffness, ultimate and breaking load, deformation caused by the applied load) and the femoral neck (load at fracture) were examined. Standard heparin (2000 IU/kg sc daily) weakened the femoral neck. Enoxaparin and the higher doses of standard heparin and nadroparin induced similar unfavourable changes in mechanical properties of the whole femur; the changes were noticeable the most after administration of enoxaparin.

scholarly journals Veninės trombembolijos profilaktika ir gydymas chirurginėje praktikoje

2005 ◽  
Vol 3 (1) ◽  
pp. 0-0
Author(s):  
Virginijus Šapoka
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
General Surgery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Thromboembolism Prophylaxis ◽  
University Medicine ◽  
Composite Risk ◽  
Evidence Based Guidelines

(SEPTINTASIS AMERIKOS KRŪTINĖS LĄSTOS GYDYTOJŲ SUTARIMAS).ĮRODYMAIS GRĮSTOS MEDICINOS REKOMENDACIJOS Virginijus ŠapokaVilniaus universiteto Medicinos fakultetoVidaus ligų, šeimos medicinos ir onkologijos klinika,Santariškių g. 2, LT-08661 VilniusEl paštas: [email protected] Veninės tromboembolinės komplikacijos chirurgijoje priklauso nuo paciento ir operacijos trombozinės rizikos laipsnio. Straipsnyje apžvelgti naujausi metaanalizinių tyrimų duomenys, pagrindžiantys veninės trombozės gydymo ir profilaktikos principus. Įrodytas profilaktinis ir gydomasis mažos molekulinės masės heparinų privalumas, palyginti su nefrakcionuotu heparinu, pagrįsta ilgalaikė gydymo mažos molekulinės masės heparinais nauda po sąnarių endoprotezavimo ir onkologinių operacijų. Reikšminiai žodžiai: veninė trombembolija, chirurgija, profilaktika, gydymas Prevention and treatment of venous thromboembolism in general surgery (THE SEVENTH AMERICAN COLLEGE OF CHEST PHYSICIANSCONFERENCE ON ANTITHROMBOTIC AND THROMBOLYTIC THERAPY).EVIDENCE-BASED GUIDELINES Virginijus ŠapokaVilnius University Medicine Faculty, Clinic of Internal Diseases,Family Medicine and Oncology,Santariškių str. 2, LT-08661 Vilnius, LithuaniaE-mail: [email protected] Complication of venous thromboembolism in each patients in general surgery, based on their individual predisposing factors and the risk associated with their current illness or procedures. Prophylaxis is then individually prescribed based on the composite risk estimate. In article review new date of clinical trial metaanalysis, based of venous thromboembolism prophylaxis and treatment principles. Proven prophylactic and therapeutic advantage with low molecular weight heparins compare with unfractionated heparins. Reasoned long term prophylaxis with low molecular weight heparins after elective hip arthroplasty and oncological surgery. Keywords: venous thrombembolism, surgery, prevention, treatment

Homozygous Protein C Deficiency: Description of a New Mutation and Successful Treatment with Low Molecular Weight Heparin

1998 ◽  
Vol 79 (04) ◽  
pp. 756-761 ◽  
Author(s):  
Paul Monagle ◽  
Maureen Andrew ◽  
Jacqueline Halton ◽  
Richard Marlar ◽  
Lawrence Jardine ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Bone Density ◽  
Skin Necrosis ◽  
Protein C ◽  
Low Molecular Weight Heparin ◽  
Whole Body ◽  
Term Therapy ◽  
Low Molecular Weight ◽  
New Mutation

SummaryWe present a kindred with a new mutation of the protein C gene, in which the proband had an unusual clinical presentation. The relationship between warfarin induced skin necrosis and level of anticoagulation was investigated. The pharmacokinetics of protein C concentrate was assessed to determine frequency of replacement therapy. The clinical and biochemical efficacy of therapy with low molecular weight heparin (LMWH) was assessed. The effect of long-term LMWH on bone density in the growing child was monitored using whole body densitometry.Warfarin therapy required an INR of greater than 3.5 to avoid skin necrosis. If protein C replacement was to be used, doses of 100 U/kg/day would have been required to maintain protein C levels consistently at or above 0.20 U/ml. While receiving prophylactic therapy with LMWH for almost 3 years, there were no episodes of recurrent thrombosis, no skin necrosis and no bleeding. Biochemical markers of in vivo thrombin generation were suppressed and within the normal range. Bone density continued to increase at the normal rate throughout the treatment period.LMWH is an effective form of long-term therapy for homozygous protein C deficient patients with measurable protein C levels.

Sign in / Sign up

Export Citation Format

Share Document