Spatial extent of fragment-ion abundances in electron transfer dissociation and electron capture dissociation mass spectrometry of peptides

2012 ◽  
Vol 330-332 ◽  
pp. 85-94 ◽  
Author(s):  
Jack Simons ◽  
Aaron R. Ledvina
Keyword(s):  
Mass Spectrometry ◽  
Electron Transfer ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Electron Transfer Dissociation ◽  
Spatial Extent

Protein O-glycosylation analysis

2012 ◽  
Vol 393 (8) ◽  
pp. 687-708 ◽  
Author(s):  
Gerhild Zauner ◽  
Radoslaw P. Kozak ◽  
Richard A. Gardner ◽  
Daryl L. Fernandes ◽  
André M. Deelder ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Electron Transfer Dissociation ◽  
Detection Methods ◽  
Glycan Analysis ◽  
Attachment Sites ◽  
Fragmentation Techniques

Abstract This review provides an overview on the methods available for analysis of O-glycosylation. Three major themes are addressed: analysis of released O-glycans including different O-glycan liberation, derivatization, and detection methods; analysis of formerly O-glycosylated peptides yielding information on O-glycan attachment sites; analysis of O-glycopeptides, representing by far the most informative but also most challenging approach for O-glycan analysis. Although there are various techniques available for the identification of O-linked oligosaccharides, the focus here is on MS fragmentation techniques such as collision-induced fragmentation, electron capture dissociation, and electron transfer dissociation. Finally, the O-glycan analytical challenges that need to be met will be discussed.

scholarly journals Proteoform Differentiation using Tandem Trapped Ion Mobility, Electron Capture Dissociation, and ToF Mass Spectrometry

2021 ◽  
Author(s):  
Kevin Jeanne Dit Fouque ◽  
Desmond Kaplan ◽  
Valery G. Voinov ◽  
Frederik H. V. Holck ◽  
Ole N. Jensen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Ion Mobility ◽  
Trapped Ion
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