scholarly journals Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring

2017 ◽  
Vol 62 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Jennifer Blaze ◽  
Arun Asok ◽  
Kristyn Borrelli ◽  
Christina Tulbert ◽  
Justin Bollinger ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Telomere Length ◽  
Maternal Stress ◽  
Adult Rat ◽  
Rat Offspring ◽  
Intrauterine Exposure ◽  
The Brain

Prenatal restraint stress decreases the expression of alpha-7 nicotinic receptor in the brain of adult rat offspring

Stress ◽  
2015 ◽  
Vol 18 (4) ◽  
pp. 435-445 ◽  
Author(s):  
Carlos J. Baier ◽  
María E. Pallarés ◽  
Ezequiela Adrover ◽  
Melisa C. Monteleone ◽  
Marcela A. Brocco ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Restraint Stress ◽  
Adult Rat ◽  
Rat Offspring ◽  
Alpha 7 ◽  
The Brain ◽  
Prenatal Restraint Stress

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

2015 ◽  
Vol 149 ◽  
pp. 131-141 ◽  
Author(s):  
C.R. Pinheiro ◽  
E.G. Moura ◽  
A.C. Manhães ◽  
M.C. Fraga ◽  
S. Claudio-Neto ◽  
...  
Keyword(s):  
Food Preference ◽  
Reward System ◽  
Nicotine Exposure ◽  
Adult Rat ◽  
Rat Offspring ◽  
The Brain

Influence of postnatal maternal stress on blood pressure and heart rate of juvenile and adult rat offspring

1990 ◽  
Vol 23 (8) ◽  
pp. 839-847 ◽  
Author(s):  
Elliott Mills ◽  
Joseph W. Bruckert ◽  
Peter G. Smith
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Maternal Stress ◽  
Adult Rat ◽  
Rat Offspring

scholarly journals DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 142
Author(s):  
Mariella Cuomo ◽  
Luca Borrelli ◽  
Rosa Della Monica ◽  
Lorena Coretti ◽  
Giulia De Riso ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Molecular Mechanisms ◽  
The Past ◽  
Targeted Analysis ◽  
Lack Of Information ◽  
High Resolution Power ◽  
Resolution Level ◽  
Health And Disease ◽  
High Doses ◽  
The Brain

The bidirectional microbiota–gut–brain axis has raised increasing interest over the past years in the context of health and disease, but there is a lack of information on molecular mechanisms underlying this connection. We hypothesized that change in microbiota composition may affect brain epigenetics leading to long-lasting effects on specific brain gene regulation. To test this hypothesis, we used Zebrafish (Danio Rerio) as a model system. As previously shown, treatment with high doses of probiotics can modulate behavior in Zebrafish, causing significant changes in the expression of some brain-relevant genes, such as BDNF and Tph1A. Using an ultra-deep targeted analysis, we investigated the methylation state of the BDNF and Tph1A promoter region in the brain and gut of probiotic-treated and untreated Zebrafishes. Thanks to the high resolution power of our analysis, we evaluated cell-to-cell methylation differences. At this resolution level, we found slight DNA methylation changes in probiotic-treated samples, likely related to a subgroup of brain and gut cells, and that specific DNA methylation signatures significantly correlated with specific behavioral scores.

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