Duloxetine prevents the effects of prenatal stress on depressive‐like and anxiety‐like behavior and hippocampal expression of pro‐inflammatory cytokines in adult male offspring rats

2016 ◽  
Vol 55 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Xiaosong Zhang ◽  
Qi Wang ◽  
Yan Wang ◽  
Jingmin Hu ◽  
Han Jiang ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Adult Male ◽  
Prenatal Stress ◽  
Male Offspring ◽  
Pro Inflammatory Cytokines

Prenatal stress prevents the desensitization of the corticosterone response to TFMPP by desmethylimipramine, but not by pheneezine, in adult male offspring

Life Sciences ◽  
1995 ◽  
Vol 57 (23) ◽  
pp. 2163-2170 ◽  
Author(s):  
Russell E. Poland ◽  
Preetam Lutchmansingh ◽  
Scott McGeoy ◽  
Denise Au ◽  
Magdaline Que ◽  
...  
Keyword(s):  
Adult Male ◽  
Prenatal Stress ◽  
Male Offspring ◽  
Corticosterone Response

scholarly journals Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring

2015 ◽  
Vol 58 (4) ◽  
pp. 427-438 ◽  
Author(s):  
Fabien Boulle ◽  
Jodi L. Pawluski ◽  
Judith R. Homberg ◽  
Barbie Machiels ◽  
Yvet Kroeze ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adult Male ◽  
Prenatal Stress ◽  
Early Life ◽  
Male Offspring ◽  
Bdnf Gene ◽  
Early Life Exposure

scholarly journals Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring

2019 ◽  
Vol 359 ◽  
pp. 886-894 ◽  
Author(s):  
Tamar L. Gur ◽  
Aditi Vadodkar Palkar ◽  
Therese Rajasekera ◽  
Jacob Allen ◽  
Anzela Niraula ◽  
...  
Keyword(s):  
Social Behavior ◽  
Adult Male ◽  
Prenatal Stress ◽  
Male Offspring

scholarly journals Injections to pregnant mice produce prenatal stress that affects aggressive behavior in their adult male offspring

2018 ◽  
Vol 106 ◽  
pp. 35-43 ◽  
Author(s):  
Monika Ogrizek ◽  
Neža Grgurevič ◽  
Tomaž Snoj ◽  
Gregor Majdič
Keyword(s):  
Aggressive Behavior ◽  
Adult Male ◽  
Prenatal Stress ◽  
Male Offspring ◽  
Pregnant Mice

Prenatal stress decreases spatial learning and memory retrieval of the adult male offspring of rats

2014 ◽  
Vol 129 ◽  
pp. 104-109 ◽  
Author(s):  
Fatemeh Modir ◽  
Mahmoud Elahdadi Salmani ◽  
Iran Goudarzi ◽  
Taghi Lashkarboluki ◽  
Kataneh Abrari
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Prenatal Stress ◽  
Memory Retrieval ◽  
Male Offspring ◽  
Spatial Learning And Memory

scholarly journals Camel whey protein improves lymphocyte function and protects against diabetes in the offspring of diabetic mouse dams

2016 ◽  
Vol 29 (4) ◽  
pp. 632-646 ◽  
Author(s):  
Mohamed H Mahmoud ◽  
Gamal Badr ◽  
Nashwa A El Shinnawy
Keyword(s):  
T Lymphocytes ◽  
Whey Protein ◽  
Inflammatory Cytokines ◽  
Plasma Levels ◽  
Male Offspring ◽  
Lymphocyte Function ◽  
Diabetic Mice ◽  
B And T Lymphocytes ◽  
Diabetic Mothers ◽  
Pro Inflammatory Cytokines

The prevalence of health problems in the offspring of pregnant diabetic mothers has recently been verified. Therefore, the present study was designed to investigate the influence of dietary camel whey protein (CWP), administered as a supplement to streptozotocin (STZ)-induced diabetic pregnant mice, on the efficiency of the immune system of the offspring. Three groups of female mice (n = 10) were used: non-diabetic control mice, diabetic mice, and diabetic mice orally administered CWP during the pregnancy and lactation periods. We then tested the immune response of B and T cells in adult male offspring (n = 15 in each group) by using flow cytometry, western blotting, and ELISAs. Our data demonstrated that the offspring of diabetic dams exhibited several postpartum complications, such as significant aberrant overexpression of activating transcription factor-3 (ATF-3), significant elevation of the plasma levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and reactive oxygen species (ROS), marked decreases in the plasma levels of IL-2 and IL-7, significant inhibition of CCL21- and CXCL12-mediated chemotaxis of B- and T-lymphocytes, and a marked decrease in the proliferative capacity of antigen-stimulated B- and T-lymphocytes. Interestingly, administration of CWP to diabetic dams substantially restored the expression of ATF-3 and the levels of ROS, pro-inflammatory cytokines, IL-2, and IL-7 in the offspring. Furthermore, the chemotaxis of B- and T-lymphocytes toward CCL21 and CXCL12 and the proliferative capacities of these lymphocytes were restored in the male offspring of diabetic mice administered CWP. Our data provide evidence of a protective role of CWP in decreasing the tendency of the offspring of diabetic mothers to develop diabetes and related complications.

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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