Developmental changes in the mammalian gonadotropin‐inhibitory hormone (GnIH) ortholog RFamide‐related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus

2011 ◽  
Vol 30 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Masahiro Murakami ◽  
Riyo Kinouchi ◽  
Tomohiro Osugi ◽  
...  
Keyword(s):  
Developmental Changes ◽  
Rat Hypothalamus ◽  
Related Peptide ◽  
Cognate Receptor ◽  
Gonadotropin Inhibitory Hormone

scholarly journals Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system

2003 ◽  
Vol 178 (2) ◽  
pp. 311-318 ◽  
Author(s):  
T Ubuka ◽  
M Ueno ◽  
K Ukena ◽  
K Tsutsui
Keyword(s):  
Japanese Quail ◽  
Median Eminence ◽  
Anterior Pituitary ◽  
Coturnix Japonica ◽  
Developmental Changes ◽  
External Layer ◽  
Mature Peptide ◽  
Gonadotropin Release ◽  
Gonadotropin Inhibitory Hormone ◽  
Precursor Mrna

We previously isolated a novel dodecapeptide containing a C-terminal -Arg-Phe-NH(2) sequence, SIKPSAYLPLRF-NH(2) (RFamide peptide), from the Japanese quail (Coturnix japonica) brain. This novel quail peptide was shown to be located in neurons of the paraventricular nucleus (PVN) and their terminals in the median eminence (ME), and to decrease gonadotropin release from cultured anterior pituitary in adult birds. We therefore designated this peptide gonadotropin-inhibitory hormone (GnIH). Furthermore, a cDNA encoding the GnIH precursor polypeptide has been characterized. To understand the physiological roles of this peptide, in the present study we analyzed developmental changes in the expressions of GnIH precursor mRNA and the mature peptide GnIH during embryonic and posthatch ages in the quail diencephalon including the PVN and ME. GnIH precursor mRNA was expressed in the diencephalon on embryonic day 10 (E10) and showed a significant increase on E17, just before hatch. GnIH was also detected in the diencephalon on E10 and increased significantly around hatch. Subsequently, the diencephalic GnIH content decreased temporarily, and again increased progressively until adulthood. GnIH-like immunoreactive (GnIH-ir) neurons were localized in the PVN on E10, but GnIH-ir fibers did not extend to the ME. However, GnIH-ir neurons increased in the PVN on E17, just before hatch, and GnIH-ir fibers extended to the external layer of the ME, as in adulthood. These results suggest that GnIH begins its function around hatch and acts as a hypothalamic factor to regulate gonadotropin release in the bird.

scholarly journals Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus

Endocrinology ◽  
2003 ◽  
Vol 144 (2) ◽  
pp. 544-551 ◽  
Author(s):  
Luisa M. Seoane ◽  
Miguel López ◽  
Sulay Tovar ◽  
Felipe F. Casanueva ◽  
Rosa Señarís ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Rat Hypothalamus ◽  
Related Peptide

scholarly journals Calcitonin gene-related peptide in noradrenergic transmission in rat hypothalamus.

Hypertension ◽  
1992 ◽  
Vol 19 (6_pt_2) ◽  
pp. 639-642 ◽  
Author(s):  
K Tsuda ◽  
S Tsuda ◽  
M Goldstein ◽  
I Nishio ◽  
Y Masuyama
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Rat Hypothalamus ◽  
Noradrenergic Transmission ◽  
Related Peptide ◽  
Calcitonin Gene

Developmental changes and day-night expression of the gonadotropin-inhibitory hormone system in the European sea bass: Effects of rearing temperature

2017 ◽  
Vol 206 ◽  
pp. 54-62 ◽  
Author(s):  
José A. Paullada-Salmerón ◽  
Guillaume Henri Loentgen ◽  
Mairi Cowan ◽  
María Aliaga-Guerrero ◽  
María del Carmen Rendón-Unceta ◽  
...  
Keyword(s):  
Sea Bass ◽  
Developmental Changes ◽  
European Sea Bass ◽  
Rearing Temperature ◽  
Gonadotropin Inhibitory Hormone ◽  
Hormone System

scholarly journals RFamide-related peptide-3 (RFRP-3) suppresses sexual maturation in a eusocial mammal

2017 ◽  
Vol 114 (5) ◽  
pp. 1207-1212 ◽  
Author(s):  
Diana E. Peragine ◽  
Martha Pokarowski ◽  
Lucia Mendoza-Viveros ◽  
Ashlyn Swift-Gallant ◽  
Hai-Ying M. Cheng ◽  
...  
Keyword(s):  
Arcuate Nucleus ◽  
Expression Patterns ◽  
Social Inhibition ◽  
Dorsomedial Nucleus ◽  
Reproductive Suppression ◽  
Related Peptide ◽  
Reproductive Axis ◽  
Neuroendocrine Mechanisms ◽  
Gonadotropin Inhibitory Hormone

Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony. Because of its inhibitory action on the reproductive axis in other vertebrates, we investigated the role of RFRP-3 in social reproductive suppression in NMRs. We report that RFRP-3 immunofluorescence expression patterns and RFRP-3/GnRH cross-talk are largely conserved in the NMR brain, with the exception of the unique presence of RFRP-3 cell bodies in the arcuate nucleus (Arc). Immunofluorescence comparisons revealed that central expression of RFRP-3 is altered by reproductive status, with RFRP-3 immunoreactivity enhanced in the paraventricular nucleus, dorsomedial nucleus, and Arc of reproductively quiescent NMRs. We further observed that exogenous RFRP-3 suppresses gonadal steroidogenesis and mating behavior in NMRs given the opportunity to undergo puberty. Together, our findings establish a role for RFRP-3 in preserving reproductive immaturity, and challenge the view that stimulatory peptides are the ultimate gatekeepers of puberty.

Developmental Changes in the Expression of Kisspeptin mRNA in Rat Hypothalamus

2010 ◽  
Vol 43 (2) ◽  
pp. 138-145 ◽  
Author(s):  
Ken Takumi ◽  
Norio Iijima ◽  
Hitoshi Ozawa
Keyword(s):  
Developmental Changes ◽  
Rat Hypothalamus

scholarly journals The Human Gonadotropin-Inhibitory Hormone Ortholog RFamide-Related Peptide-3 Suppresses Gonadotropin-Induced Progesterone Production in Human Granulosa Cells

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3435-3445 ◽  
Author(s):  
Hajime Oishi ◽  
Christian Klausen ◽  
George E. Bentley ◽  
Tomohiro Osugi ◽  
Kazuyoshi Tsutsui ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Human Granulosa Cells ◽  
Related Peptide ◽  
Progesterone Production ◽  
Gonadotropin Inhibitory Hormone

Neuropeptide Y, but Not Agouti-Related Peptide or Melanin-Concentrating Hormone, Is a Target Peptide for Orexin-A Feeding Actions in the Rat Hypothalamus

2002 ◽  
Vol 75 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Miguel López ◽  
Luisa María Seoane ◽  
María del Carmen García ◽  
Carlos Diéguez ◽  
Rosa Señarís
Keyword(s):  
Neuropeptide Y ◽  
Orexin A ◽  
Rat Hypothalamus ◽  
Target Peptide ◽  
Related Peptide ◽  
Melanin Concentrating Hormone
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