Neuropeptide Y, but Not Agouti-Related Peptide or Melanin-Concentrating Hormone, Is a Target Peptide for Orexin-A Feeding Actions in the Rat Hypothalamus

2002 ◽  
Vol 75 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Miguel López ◽  
Luisa María Seoane ◽  
María del Carmen García ◽  
Carlos Diéguez ◽  
Rosa Señarís
Keyword(s):  
Neuropeptide Y ◽  
Orexin A ◽  
Rat Hypothalamus ◽  
Target Peptide ◽  
Related Peptide ◽  
Melanin Concentrating Hormone

scholarly journals Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus

Endocrinology ◽  
2003 ◽  
Vol 144 (2) ◽  
pp. 544-551 ◽  
Author(s):  
Luisa M. Seoane ◽  
Miguel López ◽  
Sulay Tovar ◽  
Felipe F. Casanueva ◽  
Rosa Señarís ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Rat Hypothalamus ◽  
Related Peptide

Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus

Diabetes ◽  
1998 ◽  
Vol 47 (11) ◽  
pp. 1687-1692 ◽  
Author(s):  
N. A. Tritos ◽  
D. Vicent ◽  
J. Gillette ◽  
D. S. Ludwig ◽  
E. S. Flier ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Rat Hypothalamus ◽  
Functional Interactions ◽  
Melanin Concentrating Hormone

Circulating Levels of Orexin-A, Nesfatin-1, Agouti-Related Peptide, and Neuropeptide Y in Patients with Hyperthyroidism

Thyroid ◽  
2015 ◽  
Vol 25 (7) ◽  
pp. 776-783 ◽  
Author(s):  
Yusuf Tohma ◽  
Mujde Akturk ◽  
Alev Altinova ◽  
Emine Yassibas ◽  
Ethem Turgay Cerit ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Orexin A ◽  
Related Peptide ◽  
Circulating Levels

scholarly journals The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 ◽  
Vol 160 (3) ◽  
pp. R7-12 ◽  
Author(s):  
CM Edwards ◽  
S Abusnana ◽  
D Sunter ◽  
KG Murphy ◽  
MA Ghatei ◽  
...  
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Arcuate Nucleus ◽  
Physiological Role ◽  
Appetite Regulation ◽  
Similar Extent ◽  
Orexin A ◽  
Physiological Importance ◽  
Cast Doubt ◽  
Melanin Concentrating Hormone

Orexin-A and orexin-B (the hypocretins) are recently described neuropeptides suggested to have a physiological role in the regulation of food intake in the rat. We compared the orexigenic effect of the orexins administered intracerebroventricular (ICV) with other known stimulants of food intake, one strong, neuropeptide Y (NPY), and two weaker, melanin-concentrating hormone (MCH) and galanin. Orexin-A consistently stimulated food intake, but orexin-B only on occasions. Both peptides stimulated food intake significantly less than NPY, but to a similar extent to MCH (2 h food intake: NPY 3 nmol, 7.2+/-0.9 g vs saline, 1.5+/-0.2 g, P<0.001, MCH 3 nmol, 3.2+/-0.8 g vs saline, P<0.01, orexin-B 30 nmol, 2. 6+/-0.5 g vs saline, P=0.11) and to galanin (1 h food intake: galanin 3 nmol, 2.0+/-0.4 g vs saline, 0.8+/-0.2 g, P<0.05, orexin-A 3 nmol 2.2+/-0.4 g vs saline, P<0.01; 2 hour food intake: orexin-B 3 nmol, 2.4+/-0.3 g vs saline, 1.3+/-0.2 g, P<0.05). Following ICV orexin-A, hypothalamic c-fos, a maker of neuronal activation, was highly expressed in the paraventricular nucleus (PVN), and the arcuate nucleus (P<0.005 for both). IntraPVN injection of orexin-A stimulated 2 h food intake by one gram (orexin-A 0.03 nmol, 1.6+/-0. 3 g vs saline, 0.5+/-0.3 g, P<0.005). These findings support the suggestion that the orexins stimulate food intake. However, this effect is weak and may cast doubt upon their physiological importance in appetite regulation in the rat.

Melanin-concentrating hormone expression in the rat hypothalamus is not affected in an experiment of prenatal alcohol exposure

2014 ◽  
Vol 107 ◽  
pp. 102-109 ◽  
Author(s):  
Sandrine Chometton ◽  
Gabrielle Franchi-Bernard ◽  
Christophe Houdayer ◽  
Amandine Mariot ◽  
Fabrice Poncet ◽  
...  
Keyword(s):  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Rat Hypothalamus ◽  
Melanin Concentrating Hormone ◽  
Prenatal Alcohol
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