[P179]: Met signalling modulates cortical pyramidal cell dendritic development in vivo

2006 ◽  
Vol 24 (8) ◽  
pp. 571-572
Author(s):  
M. Judson ◽  
K. Eagleson ◽  
P. Levitt
Keyword(s):  
Pyramidal Cell ◽  
Dendritic Development ◽  
Cortical Pyramidal Cell

scholarly journals Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model

2014 ◽  
Vol 10 (4) ◽  
pp. e1003590 ◽  
Author(s):  
Matteo Farinella ◽  
Daniel T. Ruedt ◽  
Padraig Gleeson ◽  
Frederic Lanore ◽  
R. Angus Silver
Keyword(s):  
Pyramidal Cell ◽  
Cell Model ◽  
Temporal Integration ◽  
Network Activity ◽  
Spatio Temporal ◽  
Cortical Pyramidal Cell

Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function

2021 ◽  
Author(s):  
Alexandre Guet-McCreight ◽  
Frances K Skinner
Keyword(s):  
Pyramidal Cell ◽  
Inhibitory Interneuron ◽  
Cell Type ◽  
Cell Recruitment ◽  
External Modulation ◽  
Theta Frequency ◽  
Cell Firing ◽  
Circuit Function

The wide diversity of inhibitory cells across the brain makes them suitable to contribute to network dynamics in specialized fashions. However, the contributions of a particular inhibitory cell type in a behaving animal are challenging to untangle as one needs to both record cellular activities and identify the cell type being recorded. Thus, using computational modeling and theory to predict and hypothesize cell-specific contributions is desirable. Here, we examine potential contributions of interneuron-specific 3 (I-S3) cells - an inhibitory interneuron found in CA1 hippocampus that only targets other inhibitory interneurons - during simulated theta rhythms. We use previously developed multi-compartment models of oriens lacunosum-moleculare (OLM) cells, the main target of I-S3 cells, and explore how I-S3 cell inputs during in vitro and in vivo scenarios contribute to theta. We find that I-S3 cells suppress OLM cell spiking, rather than engender its spiking via post-inhibitory rebound mechanisms, and contribute to theta frequency spike resonance during simulated in vivo scenarios. To elicit recruitment similar to in vitro experiments, inclusion of disinhibited pyramidal cell inputs is necessary, implying that I-S3 cell firing broadens the window for pyramidal cell disinhibition. Using in vivo virtual networks, we show that I-S3 cells contribute to a sharpening of OLM cell recruitment at theta frequencies. Further, shifting the timing of I-S3 cell spiking due to external modulation shifts the timing of the OLM cell firing and thus disinhibitory windows. We propose a specialized contribution of I-S3 cells to create temporally precise coordination of modulation pathways.

Arecoline Induces Theta Rhythm, Reduces Pyramidal Cell Excitability and Moderately Impairs LTP In Vivo

1988 ◽  
pp. 155-158 ◽  
Author(s):  
H. R. Olpe ◽  
H. Jutzeler ◽  
E. Kueng ◽  
P. Campiche ◽  
K. Klebs ◽  
...  
Keyword(s):  
Pyramidal Cell ◽  
Theta Rhythm ◽  
Cell Excitability

scholarly journals Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites

Neuron ◽  
2011 ◽  
Vol 69 (5) ◽  
pp. 885-892 ◽  
Author(s):  
Tiago Branco ◽  
Michael Häusser
Keyword(s):  
Pyramidal Cell ◽  
Synaptic Integration ◽  
Cortical Pyramidal Cell

The Cortical Pyramidal Cell as a Set of Interacting Error Backpropagating Dendrites: Mechanism for Discovering Nature’s Order

2003 ◽  
pp. 25-64 ◽  
Author(s):  
Oleg V. Favorov ◽  
Joseph T. Hester ◽  
Douglas G. Kelly ◽  
Dan Ryder ◽  
Mark Tommerdahl
Keyword(s):  
Pyramidal Cell ◽  
Cortical Pyramidal Cell

Identifying the Functional Role of Martinotti Cells in Cortical Sensory Processing

2009 ◽  
Vol 102 (1) ◽  
pp. 9-11 ◽  
Author(s):  
James C. H. Cottam
Keyword(s):  
Sensory Processing ◽  
Pyramidal Cell ◽  
Functional Significance ◽  
Functional Role ◽  
Neural Computation ◽  
Inhibitory Interneurons ◽  
Local Circuit ◽  
Processing Function

Inhibitory interneurons are highly diverse, although the functional significance of their diversity is not yet well understood. This presents a barrier to understanding neural computation at the local circuit level. This review focuses on a recent study by Murayama et al. who used a novel in vivo technique in neocortex to demonstrate a specific sensory processing function of dendritic-targeting Martinotti interneurons. The function of Martinotti cells arises from their interaction with layer 5 pyramidal cell dendrites.

Post-ischemic potentiation of Schaffer collateral/CA1 pyramidal cell responses of the rat hippocampus in vivo: involvement of receptors

1993 ◽  
Vol 611 (1) ◽  
pp. 155-159 ◽  
Author(s):  
Shuhei Miyazaki ◽  
Yoichi Katayama ◽  
Makoto Furuichi ◽  
Kosaku Kinoshita ◽  
Tatsuro Kawamata ◽  
...  
Keyword(s):  
Pyramidal Cell ◽  
Rat Hippocampus ◽  
Schaffer Collateral ◽  
Cell Responses

scholarly journals Presynaptic cholinergic neuromodulation alters the temporal dynamics of short-term depression at parvalbumin-positive basket cell synapses from juvenile CA1 mouse hippocampus

2015 ◽  
Vol 113 (7) ◽  
pp. 2408-2419 ◽  
Author(s):  
J. Josh Lawrence ◽  
Heikki Haario ◽  
Emily F. Stone
Keyword(s):  
Pyramidal Cell ◽  
Acetylcholine Receptors ◽  
Temporal Dynamics ◽  
Hippocampal Slices ◽  
Pyramidal Cells ◽  
Calcium Transient ◽  
Muscarinic Acetylcholine Receptors ◽  
Presynaptic Calcium

Parvalbumin-positive basket cells (PV BCs) of the CA1 hippocampus are active participants in theta (5–12 Hz) and gamma (20–80 Hz) oscillations in vivo. When PV BCs are driven at these frequencies in vitro, inhibitory postsynaptic currents (IPSCs) in synaptically connected CA1 pyramidal cells exhibit paired-pulse depression (PPD) and multiple-pulse depression (MPD). Moreover, PV BCs express presynaptic muscarinic acetylcholine receptors (mAChRs) that may be activated by synaptically released acetylcholine during learning behaviors in vivo. Using acute hippocampal slices from the CA1 hippocampus of juvenile PV-GFP mice, we performed whole cell recordings from synaptically connected PV BC-CA1 pyramidal cell pairs to investigate how bath application of 10 μM muscarine impacts PPD and MPD at CA1 PV BC-pyramidal cell synapses. In accordance with previous studies, PPD and MPD magnitude increased with stimulation frequency. mAChR activation reduced IPSC amplitude and transiently reduced PPD, but MPD was largely maintained. Consistent with a reduction in release probability ( pr), MPD and mAChR activation increased both the coefficient of variation of IPSC amplitudes and the fraction of failures. Using variance-mean analysis, we converted MPD trains to pr functions and developed a kinetic model that optimally fit six distinct pr conditions. The model revealed that vesicular depletion caused MPD and that recovery from depression was dependent on calcium. mAChR activation reduced the presynaptic calcium transient fourfold and initial pr twofold, thereby reducing PPD. However, mAChR activation slowed calcium-dependent recovery from depression during sustained repetitive activity, thereby preserving MPD. Thus the activation of presynaptic mAChRs optimally protects PV BCs from vesicular depletion during short bursts of high-frequency activity.

Spatiotemporal structure of depolarization spread in cortical pyramidal cell populations evoked by diffuse retinal light flashes

1999 ◽  
Vol 16 (1) ◽  
pp. 65-79 ◽  
Author(s):  
DAVID M. SENSEMAN
Keyword(s):  
Visual Cortex ◽  
Pyramidal Cell ◽  
Spatiotemporal Structure ◽  
Retinal Stimulation ◽  
Medial Cortex ◽  
Photodiode Array ◽  
Initial Activation ◽  
Cortical Pyramidal Cell ◽  
Light Flashes ◽  
Stimulation Of

The spatiotemporal structure of cortical activity evoked by diffuse light flashes was investigated in an isolated eyecup-brain preparation of the pond turtle, Pseudemys scripta. By combining a photomicroscopic image of the preparation with voltage-sensitive dye signals recorded by a 464-element photodiode array, the spread of depolarization within different cortical areas could be directly visualized with millisecond temporal resolution. Diffuse stimulation of the contralateral eyecup initially depolarized the visual cortex at the junction between its lateral and medial divisions in a small area rostral of the ventricular eminence. From this point, the depolarization spread at different velocities (10–100 μm/ms) depending upon the direction of travel. Since the initial depolarization was always in the rostral pole, the largest spread invariably occurred in a rostral → caudal direction. Within the confines of the medial visual cortex, depolarization spread at a constant velocity but slowed after entering the adjoining medial cortex. Increasing the stimulus illuminance increased the velocity of spread. Rostrocaudal spread of depolarization was also observed in response to electrical stimulation of the geniculocortical pathway and by direct focal stimulation of the cortical sheet. These data suggest that excitatory connections between pyramidal cell clusters play a prominent role in the initial activation of the cortex by diffuse retinal stimulation.

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