Perinatal exposure to GABA-transaminase inhibitor impaired psychomotor function in the developing and adult mouse

2004 ◽  
Vol 22 (3) ◽  
pp. 137-147 ◽  
Author(s):  
T. Levav ◽  
T. Saar ◽  
L. Berkovich ◽  
H. Golan
Keyword(s):  
Adult Mouse ◽  
Perinatal Exposure ◽  
Psychomotor Function ◽  
Gaba Transaminase ◽  
Gaba Transaminase Inhibitor

scholarly journals Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina

2008 ◽  
Vol 27 (8) ◽  
pp. 2177-2187 ◽  
Author(s):  
Qing-Ping Wang ◽  
Firas Jammoul ◽  
Agnès Duboc ◽  
Jie Gong ◽  
Manuel Simonutti ◽  
...  
Keyword(s):  
Neuronal Plasticity ◽  
Mouse Retina ◽  
Gaba Transaminase ◽  
Treatment Of Epilepsy ◽  
Gaba Transaminase Inhibitor

Vigabatrin, the gaba-transaminase inhibitor, damages cone photoreceptors in rats

2004 ◽  
Vol 138 (3) ◽  
pp. 516
Author(s):  
A. Duboc ◽  
N. Hanoteau ◽  
M. Simonutti ◽  
G. Rudolf ◽  
A. Nehlig ◽  
...  
Keyword(s):  
Cone Photoreceptors ◽  
Gaba Transaminase ◽  
Gaba Transaminase Inhibitor

Effects of increase of brain GABA levels on the hypothalamic-pituitary-luteinizing hormone axis in rats

1984 ◽  
Vol 106 (3) ◽  
pp. 298-304 ◽  
Author(s):  
Alfredo O. Donoso ◽  
Arturo M. Banzan
Keyword(s):  
Luteinizing Hormone ◽  
Inhibitory Action ◽  
Ovariectomized Rats ◽  
Aminooxyacetic Acid ◽  
Gaba Transaminase ◽  
Inhibitory Feedback ◽  
Gaba Antagonist ◽  
Lh Release ◽  
Brain Gaba ◽  
Gaba Transaminase Inhibitor

Abstract. The effects of increasing brain GABA levels by administration of aminooxyacetic acid (AOAA), a GABA-transaminase inhibitor, on tonic and induced LH release were evaluated in ovariectomized rats. Pulsatile LH release was clearly inhibited by AOAA. Mean plasma LH levels fell, the frequently of pulses decreased, and the intervals between pulses increased. An absence of LH pulses was seen in some animals. Administration of the GABA antagonist, bicuculline, prevented these modifications. In addition, it enhanced mean plasma LH levels. AOAA blunted the rise of plasma LH levels produced by either oestradiol or progesterone in oestradiol-primed ovariectomized rats. In contrast, the AOAA treatment apparently facilitated the inhibitory feedback of oestradiol on LH release. The acute release of LH produced by LRH injection was not altered by AOAA. The results support the view that brain GABA exerts an inhibitory action on LH release in the rat.

The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (γ-vinyl GABA)

1996 ◽  
Vol 21 (9) ◽  
pp. 1031-1041 ◽  
Author(s):  
D. Manor ◽  
D. L. Rothman ◽  
G. F. Mason ◽  
F. Hyder ◽  
O. A. C. Petroff ◽  
...  
Keyword(s):  
Gaba Transaminase ◽  
Gaba Transaminase Inhibitor

Chronic Toxicity Studies with Vigabatrin, A GABA-Transaminase Inhibitor

1990 ◽  
Vol 18 (2) ◽  
pp. 225-238 ◽  
Author(s):  
John P. Gibson ◽  
John T. Yarrington ◽  
David E. Loudy ◽  
Clifford G. Gerbig ◽  
Gail H. Hurst ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Gaba Transaminase ◽  
Toxicity Studies ◽  
Gaba Transaminase Inhibitor
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