scholarly journals Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart

2016 ◽  
Vol 68 (6) ◽  
pp. 856-861 ◽  
Author(s):  
Vimal Agrawal ◽  
Jeetendra Kumar Gupta ◽  
Shaiba Sana Qureshi ◽  
Vishal Kumar Vishwakarma
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats

Hepatology ◽  
2004 ◽  
Vol 40 (3) ◽  
pp. 583-589 ◽  
Author(s):  
Luping Guo ◽  
Katharine S. Richardson ◽  
Lindsay M. Tucker ◽  
Mark A. Doll ◽  
David W. Hein ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Hepatic Ischemia ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Hepatic Ischemia Reperfusion

scholarly journals Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury

2016 ◽  
Vol 42 (6) ◽  
pp. 277-285 ◽  
Author(s):  
K. Kehoe ◽  
J. F. Gielis ◽  
G. Vliegen ◽  
R. Van Elzen ◽  
R. Verkerk ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Inhibition of the Renin-Angiotensin System protects gastric mucosa against ischemia/reperfusion injury

2001 ◽  
Vol 120 (5) ◽  
pp. A196 ◽  
Author(s):  
Michal W. Pawlik ◽  
Ryszard Sendur ◽  
Jaroslaw Biernat ◽  
Tomasz Brzozowski ◽  
Stanislaw J. Konturek ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Inhibition of the Renin-Angiotensin System protects gastric mucosa against ischemia/reperfusion injury

2001 ◽  
Vol 120 (5) ◽  
pp. A196-A196
Author(s):  
M PAWLIK ◽  
R SENDUR ◽  
J BIERNAT ◽  
T BRZOZOWSKI ◽  
S KONTUREK ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Increased Endogenous Activity of the Renin-Angiotensin System Reduces Infarct Size in the Rats with Early Angiotensin II-dependent Hypertension which Survive the Acute Ischemia/Reperfusion Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Zuzana Husková ◽  
Soňa Kikerlová ◽  
Janusz Sadowski ◽  
Petra Alánová ◽  
Lenka Sedláková ◽  
...  
Keyword(s):  
Infarct Size ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Ang Ii ◽  
At1 Receptors ◽  
Angiotensin System ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

We investigated the role of the interaction between hypertension and the renin-angiotensin system in the pathophysiology of myocardial ischemia/reperfusion injury. We hypothesized that in the early phase of angiotensin II (ANG II)-dependent hypertension with developed left ventricular hypertrophy, cardioprotective mechanism(s) are fully activated. The experiments were performed in transgenic rats with inducible hypertension, noninduced rats served as controls. The early phase of ANG II-dependent hypertension was induced by five-days (5 days) dietary indole-3-carbinol administration. Cardiac hypertrophy, ANG II and ANG 1–7 levels, protein expression of their receptors and enzymes were determined. Separate groups were subjected to acute myocardial ischemia/reperfusion injury, and infarct size and ventricular arrhythmias were assessed. Induced rats developed marked cardiac hypertrophy accompanied by elevated ANG levels. Ischemia/reperfusion mortality was significantly higher in induced than noninduced rats (52.1 and 25%, respectively). The blockade of AT1 receptors with losartan significantly increased survival rate in both groups. Myocardial infarct size was significantly reduced after 5 days induction (by 11%), without changes after losartan treatment. In conclusion, we confirmed improved cardiac tolerance to ischemia/reperfusion injury in hypertensive cardiohypertrophied rats and found that activation of AT1 receptors by locally produced ANG II in the heart was not the mechanism underlying infarct size reduction.

Sign in / Sign up

Export Citation Format

Share Document